CAS 74504-53-3

A-dendrotoxin from dendroaspis*angusticeps

Description:

A-dendrotoxin is a neurotoxic peptide derived from the venom of the black mamba (Dendroaspis angusticeps). It is characterized by its ability to selectively block certain types of potassium channels, particularly the voltage-gated potassium channels (Kv) in neurons. This action leads to prolonged depolarization of the nerve membrane, resulting in increased neurotransmitter release and heightened neuronal excitability. A-dendrotoxin is composed of a relatively small chain of amino acids, typically exhibiting a stable three-dimensional structure that is crucial for its biological activity. The toxin is of significant interest in pharmacological research due to its potential applications in understanding ion channel function and developing therapeutic agents for neurological disorders. Additionally, its specificity for certain potassium channels makes it a valuable tool for studying the physiological roles of these channels in various cellular processes. As a venom component, A-dendrotoxin contributes to the overall toxicity of the black mamba, which is known for its potent venom and rapid effects on the nervous system.

Formula: C₃₀₅H₄₇₈N₉₈O₈₄S₆

Synonyms:

• Toxin C(13)S(2)C(3)
• Toxin C-S2-C
• Toxin C13S2C3

α-Dendrotoxin

CAS: 74504-53-3

α-Dendrotoxin (α-DTX), from the venom of the Eastern green mamba, Dendroaspis angusticeps, selectively blocks voltage-gated inactivating K⁺ channels in synaptosomes.

Formula: C₃₀₅H₄₇₂N₉₈O₈₄S₆

Purity: 97.5%

Color and Shape: Whitish Powder

Molecular weight: 7048.11

Ref: 01-4030552

α-Dendrotoxin

CAS: 74504-53-3

Ref: 7W-GL6933

Alpha-Dendrotoxin

CAS: 74504-53-3

Alpha-dendrotoxin is a type of neurotoxin that blocks the voltage-gated sodium channel, which provides the neuron with a steady supply of energy. This toxin is found in the venom of certain snakes and can cause paralysis and death. Alpha-dendrotoxin binds to site 1 on the voltage-gated sodium channel and prevents it from opening. It does this by binding to its receptor, which is located on the inside surface of the cell membrane, thus blocking other ions from entering or leaving the cell. The blockage of ions leads to neuronal function impairment, such as memory loss or muscle paralysis.

Formula: C₃₀₅H₄₇₂N₉₈O₈₄S₆

Purity: Min. 95 Area-%

Color and Shape: Powder

Molecular weight: 7,048.02 g/mol

Ref: 3D-FD108355