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CAS 74578-38-4

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Tegafur-uracil mixt.

Description:
Tegafur-uracil mixture, commonly referred to as UFT, is an oral chemotherapeutic agent used primarily in the treatment of various cancers, including colorectal cancer. It is a combination of tegafur, a prodrug of 5-fluorouracil (5-FU), and uracil, which enhances the efficacy of tegafur by inhibiting its metabolism. This combination allows for a more sustained release of the active drug, improving therapeutic outcomes while potentially reducing side effects associated with high doses of 5-FU. The mechanism of action involves the inhibition of thymidylate synthase, leading to impaired DNA synthesis and cell division in rapidly dividing cancer cells. UFT is typically administered in a specific dosing regimen, and its effectiveness can vary based on individual patient factors, including genetic variations in drug metabolism. As with any chemotherapeutic agent, monitoring for side effects and interactions with other medications is essential during treatment. Overall, the tegafur-uracil mixture represents a significant advancement in cancer therapy, providing a more manageable oral option for patients.
Formula:C8H9FN2O3·C4H4N2O2
InChI:InChI=1S/C8H9FN2O3.C4H4N2O2/c9-5-4-11(6-2-1-3-14-6)8(13)10-7(5)12;7-3-1-2-5-4(8)6-3/h4,6H,1-3H2,(H,10,12,13);1-2H,(H2,5,6,7,8)
InChI key:InChIKey=DHMYGZIEILLVNR-UHFFFAOYSA-N
SMILES:O=C1N(C=C(F)C(=O)N1)C2CCCO2.O=C1NC(=O)NC=C1
Synonyms:
  • 2,4(1H,3H)-Pyrimidinedione, 5-fluoro-1-(tetrahydro-2-furanyl)-, mixt. with 2,4(1H,3H)-pyrimidinedione
  • 2,4(1H,3H)-Pyrimidinedione, mixt. contg.
  • 2,4(1H,3H)-pyrimidinedione, compd. with 5-fluoro-1-(tetrahydro-2-furanyl)-2,4(1H,3H)-pyrimidinedione (1:1)
  • 5-Fluoro-1-(tetrahydro-2-furanyl)-2,4(1H,3H)-pyrimidinedione mixt. with 2,4(1H,3H)-Pyrimidinedione
  • Tegafur-uracil mixt.
  • Uftoral
  • Uracil-Futraful mixt.
  • Youfuding
  • UFT
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