CAS 74596-17-1

3',5'-di-O-acetyl-2'-deoxy-5-fluoro-3-(3-methylbenzoyl)uridine

Description:

3',5'-di-O-acetyl-2'-deoxy-5-fluoro-3-(3-methylbenzoyl)uridine is a modified nucleoside that exhibits unique structural and chemical characteristics. This compound features a uridine backbone with specific acetyl and fluoro substitutions, which enhance its stability and bioactivity. The presence of the 3-methylbenzoyl group contributes to its lipophilicity, potentially influencing its cellular uptake and interaction with biological targets. The acetyl groups at the 3' and 5' positions provide protection against enzymatic degradation, making it more resistant to nucleases. The fluorine atom at the 5-position can alter the compound's hydrogen bonding capabilities and may enhance its binding affinity to nucleic acid targets. This compound is of interest in medicinal chemistry and pharmaceutical research, particularly in the development of antiviral agents or as a tool in nucleic acid studies. Its unique modifications may also affect its pharmacokinetic properties, making it a candidate for further investigation in drug development.

Formula: C₂₁H₂₁FN₂O₈

InChI: InChI=1/C21H21FN2O8/c1-11-5-4-6-14(7-11)19(27)24-20(28)15(22)9-23(21(24)29)18-8-16(31-13(3)26)17(32-18)10-30-12(2)25/h4-7,9,16-18H,8,10H2,1-3H3/t16-,17+,18+/m0/s1

Synonyms:

• Uridine, 2'-deoxy-5-fluoro-3-(3-methylbenzoyl)-, 3',5'-diacetate