CAS 747-36-4: Hydroxychloroquine sulfate
Description:Hydroxychloroquine sulfate is an antimalarial and immunomodulatory medication primarily used to treat malaria, rheumatoid arthritis, and lupus erythematosus. It is a derivative of chloroquine and functions by interfering with the growth of parasites in the red blood cells. The compound is characterized by its ability to inhibit the lysosomal activity within cells, which is crucial for the survival of certain pathogens. Hydroxychloroquine sulfate is typically administered in oral form and is known for its relatively low toxicity profile compared to other antimalarials. Its chemical structure includes a 4-aminoquinoline moiety, which is essential for its pharmacological activity. The sulfate salt form enhances its solubility and stability. Common side effects may include gastrointestinal disturbances, skin reactions, and, in rare cases, retinal toxicity with prolonged use. Due to its immunomodulatory effects, hydroxychloroquine has gained attention in various off-label uses, particularly in autoimmune diseases. However, its efficacy and safety in these contexts continue to be the subject of ongoing research and clinical evaluation.
Formula:C18H26ClN3O·H2O4S
InChI:InChI=1S/C18H26ClN3O.H2O4S/c1-3-22(11-12-23)10-4-5-14(2)21-17-8-9-20-18-13-15(19)6-7-16(17)18;1-5(2,3)4/h6-9,13-14,23H,3-5,10-12H2,1-2H3,(H,20,21);(H2,1,2,3,4)
InChI key:InChIKey=JCBIVZZPXRZKTI-UHFFFAOYSA-N
SMILES:O=S(=O)(O)O.ClC=1C=CC=2C(=NC=CC2NC(C)CCCN(CC)CCO)C1
- Synonyms:
- 2-((4-((7-Chloro-4-quinolyl)amino)pentyl)ethylamino)ethanol sulfate
- 2-([4-[(7-Chloroquinolin-4-yl)amino]pentyl](ethyl)amino)ethan-1-ol; sulfuric acid
- 7-Chloro-4-[4-N-ethyl-N-beta-hydroxyethylamino-1-methylbutylamino]quinoline sulfate
- 7-Chloro-4-[4-[ethyl(2-hydroxyethyl)amino]-1-methylbutylamino]-quinoline sulfate
- 7-chloro-4-({(1R)-4-[ethyl(2-hydroxyethyl)ammonio]-1-methylbutyl}amino)quinolinium
- 7-chloro-4-({(1S)-4-[ethyl(2-hydroxyethyl)ammonio]-1-methylbutyl}amino)quinolinium
- Ercoquin
- Ethanol, 2-[[4-[(7-chloro-4-quinolinyl)amino]pentyl]ethylamino]-, sulfate (1:1)
- Ethanol, 2-[[4-[(7-chloro-4-quinolinyl)amino]pentyl]ethylamino]-, sulfate (1:1) (salt)
- Ethanol, 2-[[4-[(7-chloro-4-quinolyl)amino]pentyl]ethylamino]-, sulfate (1:1) (salt)
- See more synonyms
- Hydrochloroquine Sulfate
- Hydroxy chloroquine sulfate
- Hydroxychloroquine sulfate
- NSC 4375
- Plaquenil
- Plaquenil sulfate
- Quensyl
- Zinc 01530654
