CAS 7471-73-0

5-Hydroxy-8-methoxypsoralen

Description:

5-Hydroxy-8-methoxypsoralen, also known as 5-Hydroxy-8-methoxy-psoralen or simply HMP, is a naturally occurring compound belonging to the class of furanocoumarins. It is derived from plants, particularly those in the Apiaceae family, and is known for its phototoxic properties. This compound exhibits a molecular structure that includes a furan ring and a coumarin moiety, contributing to its biological activity. HMP is primarily recognized for its role in phototherapy, particularly in the treatment of skin disorders such as psoriasis and vitiligo, where it is used in conjunction with ultraviolet light to enhance therapeutic effects. The substance has been studied for its potential anticancer properties, as it can intercalate with DNA upon UV activation, leading to the formation of DNA cross-links. Additionally, HMP has antioxidant properties, which may contribute to its protective effects against oxidative stress. However, its use is accompanied by potential side effects, including skin irritation and increased sensitivity to sunlight, necessitating careful management in therapeutic applications.

Formula: C₁₂H₈O₅

InChI: InChI=1S/C12H8O5/c1-15-12-10-7(4-5-16-10)9(14)6-2-3-8(13)17-11(6)12/h2-5,14H,1H3

InChI key: InChIKey=XPFCGZWOHNGDSP-UHFFFAOYSA-N

SMILES: O(C)C=1C2=C(C(O)=C3C1OC=C3)C=CC(=O)O2

Synonyms:

• 4-Hydroxy-9-methoxy-7H-furo[3,2-g][1]benzopyran-7-one
• 7H-Furo[3,2-g][1]benzopyran-7-one, 4-hydroxy-9-methoxy-
• 5-Hydroxy-8-methoxypsoralen
• 4-Hydroxyisopimpinellin
• 5-Hydroxyxanthotoxin

5-Hydroxy-8-methoxypsoralen

CAS: 7471-73-0

5-Hydroxy-8-methoxypsoralen, a CYP inhibitor, treats psoriasis, eczema, vitiligo, and skin lymphomas with phototherapy.

Formula: C₁₂H₈O₅

Color and Shape: Solid

Molecular weight: 232.191

Ref: TM-T40859

5-Hydroxyxanthotoxin

CAS: 7471-73-0

Formula: C₁₂H₈O₅

Purity: 95%~99%

Molecular weight: 232.191

Ref: BP-BP0087

5-Hydroxyxanthotoxin

CAS: 7471-73-0

5-Hydroxyxanthotoxin is a naturally occurring furanocoumarin, which is derived primarily from the seeds and roots of certain plant species, including Ammi majus and Psoralea corylifolia. This compound exhibits its mode of action through the ability to intercalate with DNA and form covalent bonds upon activation by ultraviolet (UV) light, primarily impacting the cellular mechanisms. Such phototoxic activity results in the cross-linking of DNA strands, leading to cellular apoptosis or inhibition of DNA synthesis.

Formula: C₁₂H₈O₅

Purity: Min. 95%

Molecular weight: 232.19 g/mol

Ref: 3D-HAA47173

5-Hydroxyxanthotoxin

Controlled Product

CAS: 7471-73-0

Formula: C₁₂H₈O₅

Color and Shape: Light Yellow

Molecular weight: 232.19

Ref: TR-H991300