CAS 747412-49-3

AUY 922

Description:

AUY 922, with the CAS number 747412-49-3, is a small molecule inhibitor that primarily targets heat shock protein 90 (Hsp90), a chaperone protein involved in the proper folding and stabilization of various client proteins, many of which are implicated in cancer progression. This compound is part of a class of drugs known as Hsp90 inhibitors, which have garnered interest in cancer therapy due to their ability to disrupt the function of multiple oncogenic signaling pathways. AUY 922 has shown potential in preclinical studies for its efficacy against various cancer types, including solid tumors and hematological malignancies. Its mechanism of action involves binding to the ATP-binding site of Hsp90, leading to the degradation of client proteins and subsequent inhibition of tumor growth. Additionally, AUY 922 has been evaluated in clinical trials, highlighting its pharmacokinetic properties and safety profile. As research continues, the therapeutic potential of AUY 922 and its role in combination therapies may further elucidate its effectiveness in oncology.

Formula: C₂₆H₃₁N₃O₅

InChI: InChI=1S/C26H31N3O5/c1-4-27-26(32)24-23(18-7-5-17(6-8-18)15-29-9-11-33-12-10-29)25(34-28-24)20-13-19(16(2)3)21(30)14-22(20)31/h5-8,13-14,16,30-31H,4,9-12,15H2,1-3H3,(H,27,32)

InChI key: InChIKey=NDAZATDQFDPQBD-UHFFFAOYSA-N

SMILES: C(NCC)(=O)C=1C(=C(ON1)C2=CC(C(C)C)=C(O)C=C2O)C3=CC=C(CN4CCOCC4)C=C3

Synonyms:

• 3-Isoxazolecarboxamide, 5-[2,4-dihydroxy-5-(1-methylethyl)phenyl]-N-ethyl-4-[4-(4-morpholinylmethyl)phenyl]-
• 5-[2,4-Dihydroxy-5-(1-methylethyl)phenyl]-N-ethyl-4-[4-(4-morpholinylmethyl)phenyl]-3-isoxazolecarboxamide
• 5-[2,4-Dihydroxy-5-isopropylphenyl]-N-ethyl-4-[4-(4-morpholinylmethyl)phenyl]-3-isoxazolecarboxamide
• Auy 922
• Luminespib
• Nvp-Auy 922
• Nvp-Auy 922Nx
• Nvp-Auy922
• Nvr-Auy 922
• Ver 52296

Luminespib (AUY-922, NVP-AUY922)

CAS: 747412-49-3

Formula: C₂₆H₃₁N₃O₅

Purity: 98%

Color and Shape: Solid

Molecular weight: 465.5414

Ref: IN-DA00FC0O

Luminespib

CAS: 747412-49-3

Luminespib

Purity: ≥98%

Molecular weight: 465.54g/mol

Ref: 54-BUP13423

Luminespib

CAS: 747412-49-3

Luminespib (VER-52296) is an HSP90 inhibitor that inhibits HSP90α and HSP90β. Luminespib has antitumor activity. Cost-effective and quality-assured.

Formula: C₂₆H₃₁N₃O₅

Purity: 98% - 99.25%

Color and Shape: Solid

Molecular weight: 465.54

Ref: TM-T1989

5-[2,4-Dihydroxy-5-isopropylphenyl]-N-ethyl-4-{4-[(morpholin-4-yl)methyl]phenyl}isoxazole-3-carboxamide

CAS: 747412-49-3

5-[2,4-Dihydroxy-5-isopropylphenyl]-N-ethyl-4-{4-[(morpholin-4-yl)methyl]phenyl}isoxazole-3-carboxamide

Purity: ≥95%

Color and Shape: Solid

Molecular weight: 465.54g/mol

Ref: 54-OR16660

NVP-AUY922

CAS: 747412-49-3

NVP-AUY922

Formula: C₂₆H₃₁N₃O₅

Purity: >99%

Color and Shape: white solid

Molecular weight: 465.54g/mol

Ref: 54-BIFK0032

Luminespib

CAS: 747412-49-3

Inhibitor of heat shock protein Hsp90

Formula: C₂₆H₃₁N₃O₅

Purity: Min. 95%

Molecular weight: 465.54 g/mol

Ref: 3D-FL137696