CAS 74772-77-3

Ciglitazone

Description:

Ciglitazone is a synthetic compound belonging to the thiazolidinedione class of drugs, primarily used in the management of type 2 diabetes mellitus. It acts as a peroxisome proliferator-activated receptor gamma (PPAR-γ) agonist, which enhances insulin sensitivity in peripheral tissues and promotes glucose uptake. The chemical structure of ciglitazone includes a thiazolidinedione ring, contributing to its pharmacological activity. It is characterized by its ability to modulate lipid metabolism and improve glycemic control. Additionally, ciglitazone has been studied for its potential effects on cardiovascular health and inflammation. However, like other thiazolidinediones, it may be associated with side effects such as weight gain and fluid retention. Its use has been limited due to concerns over safety and efficacy compared to other diabetes medications. Overall, ciglitazone represents an important example of how synthetic compounds can be designed to target specific metabolic pathways in the treatment of chronic diseases.

Formula: C₁₈H₂₃NO₃S

InChI: InChI=1S/C18H23NO3S/c1-18(9-3-2-4-10-18)12-22-14-7-5-13(6-8-14)11-15-16(20)19-17(21)23-15/h5-8,15H,2-4,9-12H2,1H3,(H,19,20,21)

InChI key: InChIKey=YZFWTZACSRHJQD-UHFFFAOYSA-N

SMILES: C(C1SC(=O)NC1=O)C2=CC=C(OCC3(C)CCCCC3)C=C2

Synonyms:

• (+-)-5-(p-((1-Methylcyclohexyl)methoxy)benzyl)-2,4-thiazolidinedione
• 2,4-Thiazolidinedione, 5-((4-((1-methylcyclohexyl)methoxy)phenyl)methyl)-, (+-)-
• 5-[[4-[(1-Methylcyclohexyl)methoxy]phenyl]methyl]-2,4-thiazolidinedione
• 5-{4-[(1-Methylcyclohexyl)Methoxy]Benzyl}-1,3-Thiazolidine-2,4-Dione
• Add 3878
• Ciglitazona
• Ciglitazona [Spanish]
• Ciglitazone [USAN:INN]
• Ciglitazonum
• Ciglitazonum [Latin]
• U 63287
• Unii-U8Qxs1Wu8G

Ciglitizone

CAS: 74772-77-3

Formula: C₁₈H₂₃NO₃S

Purity: 98%

Color and Shape: Solid

Molecular weight: 333.4451

Ref: IN-DA003OWI

Ciglitazone

CAS: 74772-77-3

Ciglitazone

Purity: ≥98%

Molecular weight: 333.45g/mol

Ref: 54-BUP21351

Ciglitazone

CAS: 74772-77-3

M01534 - Ciglitazone

Formula: C₁₈H₂₃NO₃S

Purity: 98%

Molecular weight: 333.45

Ref: 10-M01534

Ciglitizone

CAS: 74772-77-3

Formula: C₁₈H₂₃NO₃S

Purity: ≥ 98%

Color and Shape: White to off-white powder or solid

Molecular weight: 333.45

Ref: 7W-GL8018

Ciglitazone

Controlled Product

CAS: 74772-77-3

Formula: C₁₈H₂₃NO₃S

Color and Shape: Off White Solid

Molecular weight: 333.45

Ref: TR-C441000

Ciglitazone

CAS: 74772-77-3

Ciglitazone: potent PPARγ agonist, EC50 3 μM, oral hypoglycemic; reduces insulin, blood pressure, Th17 cells, VEGF; halts gastric cancer growth.

Formula: C₁₈H₂₃NO₃S

Purity: 98.23% - 99.59%

Color and Shape: White Cyrstalline Solid

Molecular weight: 333.45

Ref: TM-T19710