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CAS 74811-65-7

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Croscarmellose sodium

Description:
Croscarmellose sodium is a cross-linked polymer of carboxymethylcellulose sodium, commonly used as a disintegrant in pharmaceutical formulations. It appears as a white to off-white powder and is highly soluble in water, forming a gel-like consistency that facilitates the rapid disintegration of tablets and capsules upon contact with moisture. This property enhances the bioavailability of active pharmaceutical ingredients by promoting their release in the gastrointestinal tract. Croscarmellose sodium is non-toxic and generally recognized as safe for use in food and pharmaceuticals. It is also characterized by its ability to swell significantly when hydrated, which aids in the breakdown of solid dosage forms. Additionally, it is stable under a wide range of pH conditions, making it versatile for various formulations. Its effectiveness as a disintegrant is influenced by factors such as particle size and concentration, and it is often used in combination with other excipients to optimize the performance of drug delivery systems.
Formula:Unspecified
Synonyms:
  • Ac-Di-Sol SD 411NF
  • Ac-Di-Sol SD 711
  • Ac-Di-Sol SDW 802
  • Ac-Di-Sol SDW 802NF
  • AcDiSol
  • Croscarmellose
  • Cross carboxymethyl cellulose sodium
  • Explocel
  • Kiccolate
  • Kiccolate ND 200
  • See more synonyms
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