CAS 74832-57-8

2-fluoro-9-[5-O-(hydroxy{[hydroxy(phosphonooxy)phosphoryl]oxy}phosphoryl)-D-arabinofuranosyl]-9H-purin-6-amine

Description:

2-fluoro-9-[5-O-(hydroxy{[hydroxy(phosphonooxy)phosphoryl]oxy}phosphoryl)-D-arabinofuranosyl]-9H-purin-6-amine, with CAS number 74832-57-8, is a complex nucleoside analog characterized by its unique structural features. This compound contains a purine base, specifically adenine, which is modified by the presence of a fluorine atom at the 2-position, enhancing its biochemical properties. The sugar moiety is a D-arabinofuranosyl unit, which is further substituted with a phosphonate group, contributing to its potential as a therapeutic agent. The presence of multiple hydroxyl and phosphonate groups suggests that this compound may exhibit significant hydrophilicity, influencing its solubility and interaction with biological systems. Such modifications can enhance its stability and efficacy as an antiviral or anticancer agent. The intricate structure indicates potential for specific interactions with enzymes or receptors, making it a subject of interest in medicinal chemistry and drug development. Overall, this compound exemplifies the complexity and versatility of nucleoside analogs in pharmaceutical applications.

Formula: C₁₀H₁₅FN₅O₁₃P₃

InChI: InChI=1/C10H15FN5O13P3/c11-10-14-7(12)4-8(15-10)16(2-13-4)9-6(18)5(17)3(27-9)1-26-31(22,23)29-32(24,25)28-30(19,20)21/h2-3,5-6,9,17-18H,1H2,(H,22,23)(H,24,25)(H2,12,14,15)(H2,19,20,21)/t3-,5-,6+,9?/m1/s1

Synonyms:

• 2-fluoro-araATP
• 9H-Purin-6-amine, 2-fluoro-9-[5-O-[hydroxy[[hydroxy(phosphonooxy)phosphinyl]oxy]phosphinyl]-β-D-arabinofuranosyl]-
• Fludarabine triphosphate trisodium

Fludarabine triphosphate

CAS: 74832-57-8

Fludarabine triphosphate inhibits key enzymes, causing cell death.

Formula: C₁₀H₁₅FN₅O₁₃P₃

Color and Shape: Solid

Molecular weight: 525.17

Ref: TM-T40862

Fludarabine triphosphate trisodium

CAS: 74832-57-8

Fludarabine triphosphate trisodium is a nucleotide analog, which is a type of chemotherapy agent derived from purine nucleosides. This compound is the active metabolite of fludarabine, sourced from synthetic chemistry designed to mimic naturally occurring nucleotides involved in DNA replication. The mode of action involves its incorporation into the DNA strand during replication, where it effectively inhibits DNA polymerase and ribonucleotide reductase. This disruption impairs DNA synthesis, leading to apoptosis or programmed cell death, particularly in rapidly dividing cancer cells.

Formula: C₁₀H₁₅FN₅O₁₃P₃·Na₃

Purity: Min. 95%

Color and Shape: White Powder

Molecular weight: 594.14 g/mol

Ref: 3D-FA103525