CAS 74847-35-1

Pyronaridine

Description:

Pyronaridine is an antimalarial compound that belongs to the class of 4-aminoquinolines. It is primarily recognized for its efficacy against Plasmodium species, the parasites responsible for malaria. The substance exhibits a unique mechanism of action, inhibiting the heme polymerization process within the parasite, which is crucial for its survival. Pyronaridine is characterized by its relatively high lipophilicity, which enhances its ability to penetrate cell membranes and reach intracellular targets. It is often studied in combination with other antimalarial agents to improve therapeutic outcomes and reduce the risk of resistance development. The compound has shown promise in clinical trials, demonstrating a favorable safety profile and effective parasite clearance rates. Additionally, its pharmacokinetic properties, including absorption, distribution, metabolism, and excretion, are essential for determining optimal dosing regimens. Overall, pyronaridine represents a significant advancement in the search for effective treatments against malaria, particularly in regions where resistance to conventional therapies is prevalent.

Formula: C₂₉H₃₂ClN₅O₂

InChI: InChI=1/C29H32ClN5O2/c1-37-26-9-8-24-28(33-26)27(23-7-6-21(30)16-25(23)32-24)31-22-14-19(17-34-10-2-3-11-34)29(36)20(15-22)18-35-12-4-5-13-35/h6-9,14-16,32-33H,2-5,10-13,17-18H2,1H3

InChI key: InChIKey=DJUFPMUQJKWIJB-UHFFFAOYSA-N

SMILES: N(C1=C2C(=NC3=C1C=CC(Cl)=C3)C=CC(OC)=N2)C4=CC(CN5CCCC5)=C(O)C(CN6CCCC6)=C4

Synonyms:

• 4-[(7-Chloro-2-methoxybenzo[b]-1,5-naphthyridin-10-yl)amino]-2,6-bis(1-pyrrolidinylmethyl)phenol
• Benzo[b]-1,5-naphthyridine, phenol deriv.
• Malaridine
• Malaridine Phosphate
• Phenol, 4-[(7-chloro-2-methoxybenzo[b]-1,5-naphthyridin-10-yl)amino]-2,6-bis(1-pyrrolidinylmethyl)-
• Phenol,4-[(7-chloro-2-methoxybenzo[b]-1,5-naphthyridin-10-yl)amino]-2,6-bis(1-pyrrolidinylmethyl)-Benzo[b]-1,5-naphthyridine
• Pyronaridine
• 4-[(7-CHLORO-2-METHOXY-1,5-DIHYDROBENZO[B][1,5]NAPHTHYRIDIN-10-YL)IMINO]-2,6-BIS(PYRROLIDIN-1-YLMETHYL)CYCLOHEXA-2,5-DIEN-1-ONE
• 4-(7-chloro-2-Methoxybenzo[b][1,5]naphthyridin-10-ylaMino)-2,6-bis(pyrrolidin-1-ylMethyl)phenol
• 4-(2-Methoxy-6-chloro-1,10-diazaanthracene-9-ylamino)-2,6-bis(pyrrolizinomethyl)phenol

Pyronaridine

CAS: 74847-35-1

Formula: C₂₉H₃₂ClN₅O₂

Purity: %

Molecular weight: 518.0497

Ref: IN-DA00G75M

Pyronaridine

CAS: 74847-35-1

Pyronaridine

Purity: ≥98%

Molecular weight: 518.05g/mol

Ref: 54-BUP14371

Pyronaridine

CAS: 74847-35-1

Pyronaridine, an oral anti-malarial, disrupts Plasmodium replication in red cells; also active against P. falciparum and E. granulosus.

Formula: C₂₉H₃₂ClN₅O₂

Purity: 99.89% - 99.90%

Color and Shape: Solid

Molecular weight: 518.05

Ref: TM-T5493

Pyronaridine

CAS: 74847-35-1

Formula: C₂₉H₃₂ClN₅O₂

Molecular weight: 518.06

Ref: 4Z-P-443003

Pyronaridine

CAS: 74847-35-1

Pyronaridine is a drug that belongs to the class of antimalarial drugs. It has been used to treat malaria, which is caused by the Plasmodium parasite. Pyronaridine inhibits the growth of malaria parasites by interfering with their digestion of hemoglobin and other proteins. It also inhibits protein synthesis in cells infected with the parasite, leading to cell lysis. Pyronaridine has been shown to be effective against chloroquine-resistant strains of malaria and may be useful in treating autoimmune diseases.

Formula: C₂₉H₃₂ClN₅O₂

Purity: Min. 98 Area-%

Color and Shape: Powder

Molecular weight: 518.05 g/mol

Ref: 3D-ZCA84735