CAS 74853-08-0

4-[4-(4-Aminophenyl)-1-piperazinyl]phenol

Description:

4-[4-(4-Aminophenyl)-1-piperazinyl]phenol, with the CAS number 74853-08-0, is an organic compound characterized by its complex structure that includes a phenolic group and a piperazine moiety. This compound typically appears as a solid and is soluble in organic solvents, with moderate solubility in water due to the presence of both hydrophobic and hydrophilic regions in its structure. It exhibits properties associated with both amines and phenols, which can influence its reactivity and interactions in biological systems. The presence of the amino group suggests potential for hydrogen bonding and reactivity in various chemical reactions, making it of interest in medicinal chemistry, particularly in the development of pharmaceuticals. Its structural features may also contribute to its biological activity, potentially affecting neurotransmitter systems or other physiological pathways. Safety data should be consulted for handling and exposure guidelines, as with any chemical substance.

Formula: C₁₆H₁₉N₃O

InChI: InChI=1S/C16H19N3O/c17-13-1-3-14(4-2-13)18-9-11-19(12-10-18)15-5-7-16(20)8-6-15/h1-8,20H,9-12,17H2

InChI key: InChIKey=WZIJMPVPOMTRNM-UHFFFAOYSA-N

SMILES: NC1=CC=C(N2CCN(CC2)C3=CC=C(O)C=C3)C=C1

Synonyms:

• 4-(4-(4-Aminophenyl)Piperazin-1Yl)Phenol
• 4-(4-Aminophenyl)-1-(4-hydroxyphenyl) piperazine
• 4-[4-(4-Aminophenyl)-1-piperazinyl]phenol
• 4-[4-(4-Aminophenyl)piperazin-1-yl]benzolol
• 4-[4-(4-Aminophenyl)piperazin-1-yl]phenol
• Phenol, 4-[4-(4-Aminophenyl)-1-Piperazinyl]-
• Posaconazole Intermediate
• 1-(4-Aminophenyl)-4-(4-hydroxyphenyl)piperazine
• 1-(4-Nitrophenyl)-4-(4-hydroxyphenyl)piperazine

1-(4-Aminophenyl)-4-(4-hydroxyphenyl)piperazine

CAS: 74853-08-0

Formula: C₁₆H₁₉N₃O

Purity: 98%

Color and Shape: Solid

Molecular weight: 269.3416

Ref: IN-DA008OTL

1-(4-Aminophenyl)-4-(4-hydroxyphenyl)piperazine

CAS: 74853-08-0

1-(4-Aminophenyl)-4-(4-hydroxyphenyl)piperazine

Purity: 98%

Molecular weight: 269.34g/mol

Ref: 54-OR80133

1-(4-Aminophenyl)-4-(4-hydroxyphenyl)piperazine

CAS: 74853-08-0

Purity: 95.0%

Color and Shape: Solid

Molecular weight: 269.3479919433594

Ref: 10-F212508

4-[4-(4-Aminophenyl)-1-piperazinyl]phendiamineol

Controlled Product

CAS: 74853-08-0

Applications 4-[4-(4-Aminophenyl)-1-piperazinyl]phendiamineol is an intermediate of Posaconazole (P689600), which is orally active antifungal triazole.
References Cacciapuoti, A., et al.: Antimicrob. Agents Chemother., 44, 2017 (2000); Herbrecht, R., et al.: Int. J. Clin. Pract., 58, 612 (2004); Panackal, A., et al.: J. Clin. Microbiol., 44, 1740 (2006); Yan, X., et al.: Guangzhou Huagong, 41, 107 (2013);

Formula: C₁₆H₁₉N₃O

Color and Shape: Neat

Molecular weight: 269.34

Ref: TR-A626090

Posaconazole Impurity 73

CAS: 74853-08-0

Formula: C₁₆H₁₉N₃O

Molecular weight: 269.35

Ref: ST-EA-CP-P24065

1-(4-Aminophenyl)-4-(4-hydroxyphenyl)piperazine

CAS: 74853-08-0

1-(4-Aminophenyl)-4-(4-hydroxyphenyl)piperazine (1APHP) is a potential antiviral drug. It has been shown to bind to viral proteins and inhibit the release of viral particles. 1APHP binds to the active site of the helicase-primase enzyme that is necessary for viral replication, thereby preventing the synthesis of new DNA. 1APHP has been shown to exhibit anticancer activity in animal cancer cell lines and in bone cancer cells. 1APHP inhibits cancer cell growth by inducing apoptosis via a multistep process that includes inhibition of protein synthesis, induction of endoplasmic reticulum stress, and activation of caspases. The crystal structure and diffraction data have been elucidated using X-ray crystallography and X-ray diffraction respectively. Molecular docking studies were performed with HIV protease as a model system to study possible interactions between 1APHP and HIV protease.

Formula: C₁₆H₁₉N₃O

Purity: Min. 95%

Molecular weight: 269.34 g/mol

Ref: 3D-FH00585

1-(4-Aminophenyl)-4-(4-hydroxyphenyl)piperazine

CAS: 74853-08-0

1-(4-Aminophenyl)-4-(4-hydroxyphenyl)piperazine is a useful organic compound for research related to life sciences. The catalog number is T65582 and the CAS number is 74853-08-0.

Formula: C₁₆H₁₉N₃O

Color and Shape: Solid

Molecular weight: 269.348

Ref: TM-T65582