CAS 74853-69-3

na-ac-neurotensin fragment 8-13

Description:

Na-ac-neurotensin fragment 8-13, with the CAS number 74853-69-3, is a synthetic peptide derived from neurotensin, a neuropeptide involved in various physiological processes, including pain modulation, regulation of body temperature, and gastrointestinal function. This specific fragment consists of amino acids 8 to 13 of the neurotensin molecule, which contributes to its biological activity. Characteristically, it is a small peptide, typically exhibiting high solubility in aqueous solutions, which is essential for its biological interactions. The peptide is known to bind to neurotensin receptors, influencing signaling pathways related to neurotransmission and hormone release. Its structure includes a sequence of amino acids that can exhibit specific conformations, impacting its binding affinity and biological efficacy. Due to its role in neurobiology, it is of interest in research related to neuropharmacology and potential therapeutic applications. As with many peptides, stability and degradation can be influenced by environmental factors such as pH and temperature, which are important considerations in its handling and storage.

Formula: C₄₀H₆₆N₁₂O₉

InChI: InChI=1/C40H66N12O9/c1-6-23(4)32(36(58)50-30(38(60)61)20-22(2)3)51-34(56)29(21-25-13-15-26(54)16-14-25)49-35(57)31-12-9-19-52(31)37(59)28(11-8-18-46-40(43)44)48-33(55)27(47-24(5)53)10-7-17-45-39(41)42/h13-16,22-23,27-32,54H,6-12,17-21H2,1-5H3,(H,47,53)(H,48,55)(H,49,57)(H,50,58)(H,51,56)(H,60,61)(H4,41,42,45)(H4,43,44,46)/t23-,27-,28-,29-,30-,31-,32-/m0/s1

SMILES: CC[C@H](C)[C@@H](C(=N[C@@H](CC(C)C)C(=O)O)O)N=C([C@H](Cc1ccc(cc1)O)N=C([C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)N=C([C@H](CCCNC(=N)N)N=C(C)O)O)O)O

Synonyms:

• Acetyl-Neurotensin (8-13)
• Ac-Arg-Arg-Pro-Tyr-Ile-Leu-OH
• N~2~-acetyl-N~5~-(diaminomethylidene)-L-ornithyl-N~5~-(diaminomethylidene)-L-ornithyl-L-prolyl-L-tyrosyl-L-isoleucyl-L-leucine
• GLP-LEU-TYR-GLU-ASN-LYS-SER-ARG-ARG-PRO-TYR-ILE-LEU: GLP-LYENKSRRPYIL
• L-Leucine, N2-acetyl-L-arginyl-L-arginyl-L-prolyl-L-tyrosyl-L-isoleucyl-
• AC-RRPYIL
• neurotensin, fragment 8-13, N-alpha-acetyl-
• na-ac-neurotensin fragment 8-13
• AC-NEUROTENSIN (8-13)
• AC-ARG-ARG-PRO-TYR-ILE-LEU
• NEUROTENSIN (8-13), N-ACETYL
• N-Acetylneurotensin(8-13)【ox】
• nα-acetyl-neurotensin fragment 8-13
• Ac-L-Arg-L-Arg-L-Pro-L-Tyr-L-Ile-L-Leu-OH
• N-ACETYL-NEUROTENSIN, 8-13

Acetyl-Neurotensin (8-13)

CAS: 74853-69-3

For cellular and molecular biology applications

Formula: C₄₀H₆₆N₁₂O₉

Molecular weight: 859.04

Ref: 02-J66967

Acetyl-Neurotensin (8-13)

CAS: 74853-69-3

The truncated sequence Ac-RRPYIL is the shortest neurotensin analog with full binding and pharmacological activities.

Formula: C₄₀H₆₆N₁₂O₉

Purity: 95.3%

Color and Shape: White Powder

Molecular weight: 859.04

Ref: 01-4008911

Acetyl neurotensin (8-13)

CAS: 74853-69-3

Acetyl neurotensin (8-13), the most concise analog of neurotensin, retains complete binding and pharmacological properties [1].

Formula: C₄₀H₆₆N₁₂O₉

Molecular weight: 859.03

Ref: TM-T76572

Acetyl-Neurotensin (8-13) Ac-Arg-Arg-Pro-Tyr-Ile-Leu-OH

CAS: 74853-69-3

Acetyl-neurotensin (8-13) Ac-Arg-Arg-Pro-Tyr-Ile-Leu-OH is a competitive antagonist of the NANC neurotransmitter, neuropeptide Y. It is a proteolytic product of neurotensin, an endogenous peptide that has been implicated in a number of physiological and pathological processes. Acetyl-neurotensin (8-13) Ac-Arg-Arg-Pro-Tyr-Ile-Leu-(OH) binds to the membrane receptors on neurons and blocks the binding of neuropeptides such as neurotensin and substance P to these receptors, thereby inhibiting their effects on the central nervous system. This compound is soluble in water and can be used for bladder protection by preventing the accumulation of urine.

Formula: C₄₀H₆₆N₁₂O₉

Purity: Min. 95%

Molecular weight: 859.03 g/mol

Ref: 3D-FA108344