CAS 74863-84-6

Argatroban

Description:

Argatroban is a synthetic direct thrombin inhibitor used primarily as an anticoagulant in clinical settings, particularly for patients with heparin-induced thrombocytopenia (HIT). It is a small molecule that selectively binds to the active site of thrombin, preventing the conversion of fibrinogen to fibrin, which is crucial in the clotting process. Argatroban is administered intravenously and has a rapid onset of action, making it suitable for acute situations. Its pharmacokinetics are characterized by a short half-life, necessitating continuous infusion for sustained anticoagulation. The substance is metabolized primarily in the liver, and its effects can be monitored using activated partial thromboplastin time (aPTT) tests. Common side effects include bleeding complications, which are a risk associated with all anticoagulants. Argatroban is also notable for its lack of cross-reactivity with heparin, making it a preferred choice for patients with a history of HIT. Overall, its unique mechanism and properties make it an important therapeutic agent in managing thrombotic disorders.

Formula: C₂₃H₃₆N₆O₅S

InChI: InChI=1S/C23H36N6O5S/c1-14-8-10-29(18(12-14)22(31)32)21(30)17(6-4-9-26-23(24)25)28-35(33,34)19-7-3-5-16-11-15(2)13-27-20(16)19/h3,5,7,14-15,17-18,27-28H,4,6,8-13H2,1-2H3,(H,31,32)(H4,24,25,26)/t14-,15?,17+,18-/m1/s1

InChI key: InChIKey=KXNPVXPOPUZYGB-IOVMHBDKSA-N

SMILES: S(N[C@H](C(=O)N1[C@@H](C(O)=O)C[C@H](C)CC1)CCCNC(=N)N)(=O)(=O)C2=C3C(=CC=C2)CC(C)CN3

Synonyms:

• (2R,4R)-1-[(2S)-5-(diaminomethylideneamino)-2-[[(3R)-3-methyl-1,2,3,4-tetrahydroquinolin-8-yl]sulfonylamino]pentanoyl]-4-methyl-piperidine-2-carboxylic acid
• (2R,4R)-1-[(2S)-5-[(Aminoiminomethyl)amino]-1-oxo-2-[[(1,2,3,4-tetrahydro-3-methyl-8-quinolinyl)sulfonyl]amino]pentyl]-4-methyl-2-piperidinecarboxylic acid
• (2R,4R)-1-[N2-3-(methyl-1,2,3,4-tetrahydro-8-quinolinesulfonyl)-L-arginyl]-4-methyl-2-piperidinecarboxylic acid monohydrate
• (2R,4R)-1-[N~5~-(diaminomethylidene)-N~2~-{[(3R)-3-methyl-1,2,3,4-tetrahydroquinolin-8-yl]sulfonyl}-L-ornithyl]-4-methylpiperidine-2-carboxylic acid
• (2R,4R)-1-{N~5~-(diaminomethylidene)-N~2~-[(3-methyl-1,2,3,4-tetrahydroquinolin-8-yl)sulfonyl]-L-ornithyl}-4-methylpiperidine-2-carboxylic acid
• (2R,4R)-1-{N~5~-(diaminomethylidene)-N~2~-[(3-methyl-1,2,3,4-tetrahydroquinolin-8-yl)sulfonyl]ornithyl}-4-methylpiperidine-2-carboxylic acid
• (2R,4R)-4-Methyl-1-[N-[(3-Methyl-1,2,3,4-Tetrahydro-8-Quinolinyl)Sulfonyl]-L-Arginyl]-2-Piperidinecarboxylic Acid
• 2-Piperidinecarboxylic acid, 1-(5-((aminoiminomethyl)amino)-1-oxo-2-(((1,2,3,4-tetrahydro-3-methyl-8-quinolinyl)sulfonyl)amino)pentyl)-4-methyl-, (2R-(1(S*(R*)),2alpha,4beta))-
• 2-Piperidinecarboxylic acid, 1-[(2S)-5-[(aminoiminomethyl)amino]-1-oxo-2-[[(1,2,3,4-tetrahydro-3-methyl-8-quinolinyl)sulfonyl]amino]pentyl]-4-methyl-, (2R,4R)-
• 2-Piperidinecarboxylic acid, 1-[5-[(aminoiminomethyl)amino]-1-oxo-2-[[(1,2,3,4-tetrahydro-3-methyl-8-quinolinyl)sulfonyl]amino]pentyl]-4-methyl-, [2R-[1(2S*),2α,4β]]-[partial]-
• 21R-
• Acova
• Argatra
• Argatroban
• Argatroban Monohydrate
• Argipidin
• Argipidine
• Dk 7419
• Gn 1600
• Gn1600
• Mci 9038
• Md 805
• Novastan
• Om 805
• Slonnon

Argatroban Monohydrate

CAS: 141396-28-3, 74863-84-6

Formula: C₂₃H₃₆N₆O₅S·H₂O

Purity: >99.0%(HPLC)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 526.66

Ref: 3B-A2705

(2R,4R)-1-[(2S)-5-[(diaminomethylidene)amino]-2-[(3R)-3-methyl-1,2,3,4-tetrahydroquinoline-8-sulfonamido]pentanoyl]-4-methylpiperidine-2-carboxylic acid

CAS: 74863-84-6

Formula: C₂₃H₃₆N₆O₅S

Purity: 98%

Color and Shape: Solid

Molecular weight: 508.6341

Ref: IN-DA0038G0

Argatroban (Mixture of Diastereomers)

CAS: 74863-84-6

Formula: C₂₃H₃₆N₆O₅S

Color and Shape: White To Off-White Solid

Molecular weight: 508.64

Ref: 4Z-A-591

Argatroban

CAS: 74863-84-6

Argatroban

Purity: ≥98%

Molecular weight: 508.63g/mol

Ref: 54-BUP15629

Argatroban

CAS: 74863-84-6

Formula: C₂₃H₃₈N₆O₆S

Purity: (HPLC) ≥ 98%

Color and Shape: White to off-white powder

Molecular weight: 526.65

Ref: 7W-GP6176

Argatroban

CAS: 74863-84-6

Argatroban (MCI-9038), a specific thrombin inhibitor, which is a non-heparin anticoagulant, prevents the formation of thrombi.

Formula: C₂₃H₃₆N₆O₅S

Purity: 99.77% - >99.99%

Color and Shape: White To Off-White Crystalline Solid

Molecular weight: 508.63

Ref: TM-T0155

Argatroban

Controlled Product

CAS: 74863-84-6

Applications Synthetic thrombin inhibitor. Antithrombotic.
References Abiko, Y., et al.: Thromb. Res., 24, 285 (1981), Kikumoto, R., et al.: Biochemistry, 23, 85 (1984),

Formula: C₂₃H₃₆N₆O₅S

Color and Shape: White Powder

Molecular weight: 508.63

Ref: TR-A769000

Argatroban

CAS: 74863-84-6

Argatroban is a drug that belongs to the group of anticoagulants and is used in the treatment of blood disorders. Argatroban is an oral prodrug that undergoes hepatic metabolism to its active form, argatroban. Argatroban is a thrombin inhibitor that competes with heparin for binding to antithrombin III and thrombin, thereby preventing the formation of fibrin clots. Argatroban has been shown to be successful in treating patients with congestive heart failure or nephrology dialysis who are at risk for developing deep vein thrombosis. This drug also has a long half-life and does not require frequent monitoring, making it suitable for use in these patient populations. However, argatroban should not be used if there is hepatic impairment or if the patient has undergone recent cerebral surgery due to the risk of brain infarction.

Formula: C₂₃H₃₆N₆O₅S

Purity: Min. 95%

Color and Shape: Off-White Powder

Molecular weight: 508.64 g/mol

Ref: 3D-FA17976