CAS 748810-28-8

Vernakalant hydrochloride

Description:

Vernakalant hydrochloride is a pharmaceutical compound primarily used as an antiarrhythmic agent, specifically for the rapid conversion of atrial fibrillation to normal sinus rhythm. It is characterized by its selective action on cardiac ion channels, particularly the atrial-specific potassium channels, which helps to restore normal heart rhythm. The compound is typically administered intravenously and is known for its relatively rapid onset of action. Vernakalant hydrochloride has a unique mechanism of action that distinguishes it from other antiarrhythmic drugs, as it preferentially targets atrial tissue, minimizing effects on ventricular tissue. Its chemical structure includes a specific arrangement of functional groups that contribute to its pharmacological properties. The hydrochloride salt form enhances its solubility and stability, making it suitable for clinical use. As with any medication, potential side effects may include hypotension, bradycardia, and other cardiovascular effects, necessitating careful monitoring during administration. Overall, Vernakalant hydrochloride represents a targeted approach to managing atrial fibrillation in clinical settings.

Formula: C₂₀H₃₁NO₄·ClH

InChI: InChI=1S/C20H31NO4.ClH/c1-23-19-8-7-15(13-20(19)24-2)10-12-25-18-6-4-3-5-17(18)21-11-9-16(22)14-21;/h7-8,13,16-18,22H,3-6,9-12,14H2,1-2H3;1H/t16-,17-,18-;/m1./s1

InChI key: InChIKey=JMHYCBFEEFHTMK-IIUXMCBISA-N

SMILES: O(CCC1=CC(OC)=C(OC)C=C1)[C@H]2[C@@H](CCCC2)N3CC[C@@H](O)C3.Cl

Synonyms:

• (1R,2R)-2-((3R)-Hydroxypyrrolidinyl)-1-(3,4-dimethoxyphenethoxy)cyclohexane monohydrochloride
• (1R,2R)-2-((3R)-Hydroxypyrrolidinyl)-1-[2-(3,4-dimethoxyphenyl)ethoxy]cyclohexane monohydrochloride
• (3R)-1-[(1R,2R)-2-[2-(3,4-Dimethoxyphenyl)ethoxy]cyclohexyl]-3-pyrrolidinol monohydrochloride
• 3-Pyrrolidinol, 1-[(1R,2R)-2-[2-(3,4-dimethoxyphenyl)ethoxy]cyclohexyl]-, hydrochloride (1:1), (3R)-
• 3-Pyrrolidinol, 1-[(1R,2R)-2-[2-(3,4-dimethoxyphenyl)ethoxy]cyclohexyl]-, hydrochloride, (3R)-
• Brinavess
• Rsd-1235
• Vernakalant hydrochloride

Vernakalant Hydrochloride

CAS: 748810-28-8

Formula: C₂₀H₃₂ClNO₄

Purity: 99%

Color and Shape: Solid

Molecular weight: 385.9254

Ref: IN-DA00G3QF

(R)-1-((1R,2R)-2-(3,4-Dimethoxyphenethoxy)Cyclohexyl)Pyrrolidin-3-Ol Hydrochloride

CAS: 748810-28-8

(R)-1-((1R,2R)-2-(3,4-Dimethoxyphenethoxy)Cyclohexyl)Pyrrolidin-3-Ol Hydrochloride

Purity: 98%

Molecular weight: 385.93g/mol

Ref: 54-OR1024308

Vernakalant Hydrochloride

CAS: 748810-28-8

Vernakalant Hydrochloride

Purity: ≥98%

Molecular weight: 385.93g/mol

Ref: 54-BUP05236

Vernakalant HCl

CAS: 748810-28-8

Formula: C₂₀H₃₁NO₄·HCl

Color and Shape: White To Off-White Solid

Molecular weight: 349.47 36.45

Ref: 4Z-V-044007

VERNAKALANT HYDROCHLORIDE

CAS: 748810-28-8

Purity: 99%

Molecular weight: 385.9299927

Ref: 10-F866629

Vernakalant Hydrochloride

Controlled Product

CAS: 748810-28-8

Applications Vernakalant Hydrochloride is a novel, relatively atrial-selective antiarrhythmic drug that effectively and rapidly terminates atrial fibrillation (AF).
References Mao, Z.L., et. al.: J. Clin. Pharmacol., 52, 1042 (2012); Mao, Z., et. al.: J. Pharmacokinet. Pharmacodynam., 38, 541 (2011)

Formula: C₂₀H₃₁NO₄·HCl

Color and Shape: Neat

Molecular weight: 349.47 + (36.46)

Ref: TR-V128620

Vernakalant Hydrochloride

CAS: 748810-28-8

Vernakalant Hydrochloride (RSD1235 hydrochloride) is a mixed voltage- and frequency-dependent Na+ and atria-preferred K+ channel blocker.

Formula: C₂₀H₃₂ClNO₄

Purity: 99.89%

Color and Shape: Solid

Molecular weight: 385.93

Ref: TM-T17227