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CAS 749-13-3

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Trifluperidol

Description:
Trifluperidol is an antipsychotic medication belonging to the butyrophenone class, primarily used in the treatment of schizophrenia and other psychotic disorders. It is characterized by its ability to antagonize dopamine receptors, particularly the D2 subtype, which contributes to its therapeutic effects in managing symptoms of psychosis. The chemical structure of trifluperidol includes a fluorinated phenyl ring, which enhances its potency and efficacy. It is typically administered in the form of its hydrochloride salt, which improves its solubility and bioavailability. Trifluperidol exhibits a relatively long half-life, allowing for less frequent dosing compared to some other antipsychotics. Common side effects may include sedation, extrapyramidal symptoms, and potential weight gain, similar to other medications in its class. Due to its pharmacological profile, trifluperidol is often used in acute settings for rapid control of severe agitation or psychotic episodes. As with all antipsychotic medications, careful monitoring for adverse effects and individual patient response is essential during treatment.
Formula:C22H23F4NO2
InChI:InChI=1S/C22H23F4NO2/c23-19-8-6-16(7-9-19)20(28)5-2-12-27-13-10-21(29,11-14-27)17-3-1-4-18(15-17)22(24,25)26/h1,3-4,6-9,15,29H,2,5,10-14H2
InChI key:InChIKey=GPMXUUPHFNMNDH-UHFFFAOYSA-N
SMILES:OC1(C2=CC(C(F)(F)F)=CC=C2)CCN(CCCC(=O)C3=CC=C(F)C=C3)CC1
Synonyms:
  • 1-(4-Fluorophenyl)-4-[4-Hydroxy-4-[4-(Trifluoromethyl)Phenyl]-1-Piperidyl]Butan-1-One
  • 1-(4-Fluorophenyl)-4-[4-hydroxy-4-[3-(trifluoromethyl)phenyl]-1-piperidinyl]-1-butanone
  • 1-Butanone, 1-(4-fluorophenyl)-4-[4-hydroxy-4-[3-(trifluoromethyl)phenyl]-1-piperidinyl]-
  • 4-Fluoro-4-(4-Hydroxy-4-(Alpha,Alpha,Alpha-Trifluoro-M-Tolyl)Piperidino)Butyrophenone
  • 4′-Fluoro-4-[4-hydroxy-4-(α,α,α-trifluoro-m-tolyl)piperidino]butyrophenone
  • Butyrophenone, 4′-fluoro-4-[4-hydroxy-4-(α,α,α-trifluoro-m-tolyl)piperidino]-
  • Flumoperone
  • McN-JR 2498
  • NSC 170978
  • P 459
  • See more synonyms
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