CAS 74936-72-4

2,6-Dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid monomethyl ester

Description:

2,6-Dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid monomethyl ester is a complex organic compound characterized by its dihydropyridine core, which is a five-membered ring containing nitrogen. This compound features two methyl groups at the 2 and 6 positions, enhancing its lipophilicity and potentially influencing its biological activity. The presence of a nitrophenyl group at the 4 position introduces an electron-withdrawing nitro group, which can affect the compound's reactivity and interaction with biological targets. Additionally, the compound contains two carboxylic acid functionalities, which are esterified with a methyl group, indicating that it can participate in various chemical reactions, including hydrolysis and esterification. The structural features suggest potential applications in medicinal chemistry, particularly in the development of calcium channel blockers or other pharmacological agents. Its molecular structure and functional groups may also contribute to its solubility and stability in different solvents, making it a subject of interest in both synthetic and medicinal chemistry.

Formula: C₁₆H₁₆N₂O₆

InChI: InChI=1S/C16H16N2O6/c1-8-12(15(19)20)14(13(9(2)17-8)16(21)24-3)10-5-4-6-11(7-10)18(22)23/h4-7,14,17H,1-3H3,(H,19,20)

InChI key: InChIKey=JPXPPUOCSLMCHK-UHFFFAOYSA-N

SMILES: C(OC)(=O)C=1C(C(C(O)=O)=C(C)NC1C)C2=CC(N(=O)=O)=CC=C2

Synonyms:

• (±)-1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid monomethyl ester
• (±)-1,4-Dihydro-5-methoxycarbonyl-2,6-dimethyl-4-(3-nitrophenyl)-3-pyridinecarboxylic acid
• 1,4-Dhpcooh
• 1,4-Dihydro-2,6-Dimethyl-4-(3-Nitrophenyl)-3,5-Pyridinedicarboxylic Acid 3-Methyl Ester
• 1,4-Dihydro-2,6-Dimethyl-4-(3-Nitrophenyl)-3,5-Pyridinedicarboxylic Acid,Monomethylester
• 1,4-Dihydro-2,6-Dimethyl-4-(3-Ntirophenyl)-3,5-Pyridinedicarboxylic Acid Monomet
• 2,6-Dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid monomethyl ester
• 2,6-Dimethyl-5-Methoxycarbonyl-4-(3-Nitrophenyl)-1,4-Dihydordropyridine-3-Carboxylic Acid
• 2,6-Dimethyl-5-methoxycarbonyl-4-(3-nitrophenyl)-1,4-Dihydropyridine-3-carboxylic Acid
• 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 3-methyl ester
• 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, monomethyl ester
• 5-(Methoxycarbonyl)-2,6-Dimethyl-4-(3-Nitrophenyl)-1,4-Dihydropyridine-3-Carboxylic Acid
• 5-Methoxycarbonyl-2,6-Dimethyl-4-(3-Nitrophenyl)-1,4-Dihydrpyridine-3-Carboxylic Acid
• Lercanidipine mainring

Monomethyl 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate

CAS: 74936-72-4

Formula: C₁₆H₁₆N₂O₆

Purity: >98.0%(T)(HPLC)

Color and Shape: White to Light yellow powder to crystal

Molecular weight: 332.31

Ref: 3B-M2493

5-(Methoxycarbonyl)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylic acid

CAS: 74936-72-4

Formula: C₁₆H₁₆N₂O₆

Purity: 98%

Color and Shape: Solid

Molecular weight: 332.3080

Ref: IN-DA003M7P

2,6-Dimethyl-5-(methoxycarbonyl)-4-(3-nitrophenyl)-1,4-dihydroxypyridine-3-carboxylic acid

CAS: 74936-72-4

2,6-Dimethyl-5-(methoxycarbonyl)-4-(3-nitrophenyl)-1,4-dihydroxypyridine-3-carboxylic acid

Purity: 98%

Molecular weight: 364.31g/mol

Ref: 54-OR315749

Nicardipine Impurity 44

CAS: 74936-72-4

Formula: C₁₆H₁₆N₂O₆

Color and Shape: Pale Yellow Solid

Molecular weight: 332.31

Ref: 4Z-N-489

1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)pyridine-3,5-dicarboxylic Acid Methyl Ester

CAS: 74936-72-4

Color and Shape: Neat

Ref: 86-MM0092.04

Lercanidipine EP Impurity A

CAS: 74936-72-4

Formula: C₁₆H₁₆N₂O₆

Molecular weight: 332.31

Ref: ST-EA-CP-L36001

1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic Acid 3-Methyl Ester

CAS: 74936-72-4

Impurity Nicardipine USP Related Compound A
Applications 1,4-Dihydropyridine derivative used in the prevention and therapy of atherosclerotic degradation of arterial walls. Nicardipine USP Related Compound A.
References Henry, P.D., et al.: Clin. Invest. Med., 10, 601 (1987), Weinstein, D.B., et al.: Am. J. Med., 86, 27 (1989), Gaviraghi, G., et al.: Pharmacol. Res., 31, 251 (1995),

Formula: C₁₆H₁₆N₂O₆

Color and Shape: Light Yellow

Molecular weight: 332.31

Ref: TR-D449123

Nicardipine USP Related Compound A

CAS: 74936-72-4

Formula: C₁₆H₁₆N₂O₆

Molecular weight: 332.31

Ref: ST-EA-CP-N7003

5-(Methoxycarbonyl)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylic acid

CAS: 74936-72-4

Formula: C₁₆H₁₆N₂O₆

Purity: ≥98%

Color and Shape: Solid, White - Slightly pale yellow powder

Molecular weight: 332.312

Ref: 10-F213474

1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic Acid 3-Methyl Ester-d3

Controlled Product

CAS: 74936-72-4

Formula: C₁₆D₃H₁₃N₂O₆

Color and Shape: Neat

Molecular weight: 335.327

Ref: TR-D449124

1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 3-methyl ester

CAS: 74936-72-4

Lercanidipine is a calcium antagonist that binds to the calcium channels in the membranes of cells, preventing the entry of calcium ions. Lercanidipine is water soluble and can be synthesized using techniques such as elemental analysis and pharmacological techniques. It is also an ionizable drug, which means that its affinity for chloride varies with pH. Lercanidipine has been shown to have strong affinity for erythrocyte membranes and thus has a high selectivity for vascular smooth muscle cells. This drug also has a low toxicity profile and does not affect tissues other than vascular smooth muscle cells.

Formula: C₁₆H₁₆N₂O₆

Purity: Min. 95%

Color and Shape: White Powder

Molecular weight: 332.31 g/mol

Ref: 3D-FD21967