CAS 7494-34-0

(6R)-6-[(3S,8S,9S,10R,13R,14S,17R)-3-hydroxy-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]heptan-2-one (non-preferred name)

Description:

The chemical substance with the name "(6R)-6-[(3S,8S,9S,10R,13R,14S,17R)-3-hydroxy-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]heptan-2-one" and CAS number "7494-34-0" is a complex organic compound characterized by its steroid-like structure, which includes multiple chiral centers contributing to its stereochemistry. This compound features a heptanone moiety, indicating the presence of a ketone functional group, and a hydroxyl group, which suggests potential for hydrogen bonding and reactivity. The presence of a cyclopenta[a]phenanthrene core indicates that it may exhibit hydrophobic properties, typical of many steroid derivatives. Its molecular structure suggests it may interact with biological systems, potentially influencing hormonal pathways or serving as a precursor in synthetic chemistry. The specific stereochemistry and functional groups present in this compound may also affect its solubility, stability, and biological activity, making it of interest in medicinal chemistry and pharmacology.

Formula: C₂₆H₄₂O₂

InChI: InChI=1/C26H42O2/c1-17(6-5-7-18(2)27)22-10-11-23-21-9-8-19-16-20(28)12-14-25(19,3)24(21)13-15-26(22,23)4/h8,17,20-24,28H,5-7,9-16H2,1-4H3/t17-,20+,21+,22-,23+,24+,25+,26-/m1/s1

Synonyms:

• 27-Norcholest-5-en-25-one, 3-hydroxy-, (3beta)-

27-Nor-25-ketocholesterol

CAS: 7494-34-0

Applications 27-Nor-25-ketocholesterol is an intermediate in the synthesis of hydroxy derivatives of cholesterol (C432501).
References Kandutsch, A.A., et al.: J. Biol. Chem., 249, 6057 (1974);

Formula: C₂₆H₄₂O₂

Color and Shape: Off White Solid

Molecular weight: 386.6105

Ref: TR-N692095

27-Nor-25-ketocholesterol

Controlled Product

CAS: 7494-34-0

27-Nor-25-ketocholesterol is a synthetic product that is an inorganic compound. It has a competitive inhibition of intestinal cholesterol absorption and is used to lower blood cholesterol levels. 27-Nor-25-ketocholesterol is not active against the two main enzymes related to cholesterol synthesis, namely 3-hydroxy-3-methylglutaryl coenzyme A reductase and HMG coenzyme A reductase. 27-Nor-25-ketocholesterol can be used as an alternative for patients with liver disease or who are unable to take the usual medications because of intolerance. The drug inhibits the activity of these enzymes by competing with them for substrate binding sites on their respective enzyme proteins. 27-Nor-25-ketocholesterol has been shown to have estrogenic activity and may also act as a hormone antagonist. 27NOK has been shown to inhibit mitochondrial sulphatases and esterases, which are involved in the conversion of cholesterol into bile acids

Formula: C₂₆H₄₂O₂

Purity: Min. 95%

Molecular weight: 386.6 g/mol

Ref: 3D-HAA49434

27-Nor-25-ketocholesterol

CAS: 7494-34-0

Formula: C₂₆H₄₂O₂

Molecular weight: 386.61

Ref: ST-EA-CP-C71062