CAS 75172-81-5

Migalastat hydrochloride

Description:

Migalastat hydrochloride is a pharmacological agent primarily used in the treatment of Fabry disease, a genetic disorder resulting from the deficiency of the enzyme alpha-galactosidase A. This compound acts as a chaperone, stabilizing the enzyme and facilitating its proper function, which helps to reduce the accumulation of certain lipids in the body. Chemically, Migalastat hydrochloride is characterized by its specific molecular structure, which includes a chiral center, contributing to its biological activity. It is typically administered orally and is known for its favorable pharmacokinetic profile, including good absorption and distribution in the body. The hydrochloride salt form enhances its solubility and stability. Migalastat hydrochloride has undergone extensive clinical trials, demonstrating its efficacy in reducing disease-related symptoms and improving quality of life for patients with Fabry disease. As with any medication, it is essential to consider potential side effects and contraindications, and it should be used under the guidance of a healthcare professional.

Formula: C₆H₁₃NO₄·ClH

InChI: InChI=1S/C6H13NO4.ClH/c8-2-3-5(10)6(11)4(9)1-7-3;/h3-11H,1-2H2;1H/t3-,4+,5+,6-;/m1./s1

InChI key: InChIKey=ZJIHMALTJRDNQI-OLALXQGDSA-N

SMILES: C(O)[C@@H]1[C@H](O)[C@H](O)[C@@H](O)CN1.Cl

Synonyms:

• 1-Deoxygalactonojirimycin hydrochloride
• 3,4,5-Piperidinetriol, 2-(hydroxymethyl)-, hydrochloride (1:1), (2R,3S,4R,5S)-
• 3,4,5-Piperidinetriol, 2-(hydroxymethyl)-, hydrochloride, (2R,3S,4R,5S)-
• 3,4,5-Piperidinetriol, 2-(hydroxymethyl)-, hydrochloride, [2R-(2α,3α,4α,5β)]-
• Galafold
• Migalastat HCl
• Migalastat hydrochloride

3,4,5-Piperidinetriol, 2-(hydroxymethyl)-, hydrochloride,[2R-(2a,3a,4a,5b)]-

CAS: 75172-81-5

Formula: C₆H₁₄ClNO₄

Purity: 98%

Color and Shape: Solid

Molecular weight: 199.6327

Ref: IN-DA01CBEP

1-Deoxygalactonojirimycin, hydrochloride

CAS: 75172-81-5

1-Deoxygalactonojirimycin, hydrochloride

Purity: 98%

Molecular weight: 199.63g/mol

Ref: 54-BICL4269

Migalastat-15N HCl

CAS: 75172-81-5

Formula: C₆H₁₃₁₅NO₄·HCl

Color and Shape: White To Off-White Solid

Molecular weight: 164.08 36.46

Ref: 4Z-M-249002

Migalastat-d2 HCl (6,6-d2)

CAS: 75172-81-5

Formula: C₆H₁₁D₂NO₄·HCl

Molecular weight: 165.19 36.46

Ref: 4Z-M-249009

Migalastat HCl

CAS: 75172-81-5

Formula: C₆H₁₃NO₄·HCl

Color and Shape: White To Off-White Solid

Molecular weight: 163.17 36.46

Ref: 4Z-M-249001

Migalastat hydrochloride

CAS: 75172-81-5

Migalastat hydrochloride (GR181413A) 是一种可口服且具有有效和竞争性的 α-galactosidase A 抑制剂，可促进α-半乳糖苷酶A向溶酶体的运输，可用于研究法布里病。

Formula: C₆H₁₄ClNO₄

Purity: >99.99%

Color and Shape: Solid

Molecular weight: 199.63

Ref: TM-T12038

(2R,3S,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-triol hydrochloride

CAS: 75172-81-5

(2R,3S,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-triol hydrochloride

Formula: C₆H₁₃NO₄·ClH

Purity: ≥95%

Color and Shape: off-white solid

Molecular weight: 199.63g/mol

Ref: 54-OR2365T

1-Deoxygalactonojirimycin hydrochoride

CAS: 75172-81-5

Formula: C₆H₁₃NO₄·HCl

Color and Shape: White powder or crystals

Molecular weight: 199.63

Ref: 7W-GC6644

1-Deoxygalactonojirimycin Hydrochloride

CAS: 75172-81-5

Applications Proven to be an extremely potent and selective a-D-galactosidase inhibitor.
References Paulsen, H., et al.: Chem. Ber., 113, 2601 (1980),

Formula: C₆H₁₃NO₄·ClH

Color and Shape: Off White Solid

Molecular weight: 199.63

Ref: TR-D236500

1-Deoxygalactonojirimycin hydrochloride salt

CAS: 75172-81-5

Specific and potent inhibitor of lysosomal α-galactosidase with IC50 in nanomolar range. It acts as pharmacological chaperone and assists folding of the wild type and mutant versions of the enzyme. It places itself in the instable active site and prevents the damage to the enzyme during the passage through Golgi apparatus, endoplasmatic reticulum and lysosome axis. The exposure to this compound leads to increased levels of functional α-galactosidase in models for lysosomal storage disorders and brings therapeutic benefits to patients with Fabry disease.

Formula: C₆H₁₃NO₄·HCl

Purity: Min. 95 Area-%

Color and Shape: White Powder

Molecular weight: 199.63 g/mol

Ref: 3D-MD06196

(2R,3S,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-triol hydrochloride

CAS: 75172-81-5

Purity: 98+%

Molecular weight: 199.6300049

Ref: 10-F957212

Migalastat Hydrochloride

CAS: 75172-81-5

Formula: C₆H₁₃NO₄HCl

Molecular weight: 163.2 : 36.46

Ref: ST-EA-CP-M58013