CAS 75176-37-3

Zofenoprilat

Description:

Zofenoprilat is the active metabolite of the angiotensin-converting enzyme (ACE) inhibitor zofenopril, primarily used in the treatment of hypertension and heart failure. It belongs to the class of medications that help relax blood vessels, thereby lowering blood pressure and improving blood flow. Zofenoprilat exhibits a high affinity for the ACE enzyme, inhibiting its activity and preventing the conversion of angiotensin I to angiotensin II, a potent vasoconstrictor. This results in decreased vascular resistance and reduced workload on the heart. The substance is characterized by its ability to improve cardiovascular outcomes and is often administered in oral form. Zofenoprilat is also noted for its favorable pharmacokinetic profile, including a relatively long half-life, which allows for once-daily dosing. Additionally, it may have beneficial effects on renal function in patients with hypertension. As with other ACE inhibitors, potential side effects may include cough, elevated potassium levels, and hypotension, necessitating monitoring during treatment.

Formula: C₁₅H₁₉NO₃S₂

InChI: InChI=1S/C15H19NO3S2/c1-10(9-20)14(17)16-8-12(7-13(16)15(18)19)21-11-5-3-2-4-6-11/h2-6,10,12-13,20H,7-9H2,1H3,(H,18,19)/t10-,12+,13+/m1/s1

InChI key: InChIKey=UQWLOWFDKAFKAP-WXHSDQCUSA-N

SMILES: C([C@@H](CS)C)(=O)N1[C@H](C(O)=O)C[C@H](SC2=CC=CC=C2)C1

Synonyms:

• (1(R*),2Alpha,4Alpha)-1-(3-Mercapto-2-Methyl-1-Oxopropyl)-4-(Phenylthio)-L-Proline
• (2S,4S)-1-[(2R)-2-Methyl-3-Sulfanyl-Propanoyl]-4-Phenylsulfanyl-Pyrrolidine-2-Carboxylic Acid
• (4S)-1-[(2S)-3-Mercapto-2-methyl-1-oxopropyl]-4-(phenylthio)-<span class="text-smallcaps">L</span>-proline
• <span class="text-smallcaps">L</span>-Proline, 1-(3-mercapto-2-methyl-1-oxopropyl)-4-(phenylthio)-, [1(R*),2α,4α]-
• <span class="text-smallcaps">L</span>-Proline, 1-[(2S)-3-mercapto-2-methyl-1-oxopropyl]-4-(phenylthio)-, (4S)-
• Sq 26333
• L-Proline, 1-(3-mercapto-2-methyl-1-oxopropyl)-4-(phenylthio)-, [1(R*),2α,4α]-
• (4S)-1-[(2S)-3-Mercapto-2-methyl-1-oxopropyl]-4-(phenylthio)-L-proline
• L-Proline, 1-[(2S)-3-mercapto-2-methyl-1-oxopropyl]-4-(phenylthio)-, (4S)-
• Zofenoprilat

Zofenoprilat-d5

CAS: 75176-37-3

Formula: C₁₅H₁₄D₅NO₃S₂

Molecular weight: 330.48

Ref: 4Z-Z-094

Zofenoprilat

CAS: 75176-37-3

Formula: C₁₅H₁₉NO₃S₂

Color and Shape: White To Off-White Solid

Molecular weight: 325.44

Ref: 4Z-Z-093

Zofenopril

CAS: 75176-37-3

Formula: C₂₂H₂₃NO₄S₂

Molecular weight: 429.55

Ref: 7W-GP7970

Zofenoprilat

CAS: 75176-37-3

Zofenoprilat is a prodrug of enalaprilat, which is an inhibitor of angiotensin-converting enzyme (ACE). It has been shown to reduce the blood pressure in vivo and in humans. Inhibition of ACE leads to decreased levels of angiotensin II and aldosterone, which are hormones that constrict blood vessels. Zofenoprilat also inhibits the transcription-polymerase chain reaction (PCR) by binding to DNA-dependent RNA polymerase and preventing its activity. This drug may be used as an alternative to ACE inhibitors when they are contraindicated or ineffective. The inhibition of ACE by zofenoprilat also prevents the formation of angiotensin II, which is involved in the activation of pro-angiogenic processes.

Formula: C₁₅H₁₉NO₃S₂

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 325.45 g/mol

Ref: 3D-FZ41737

Zofenoprilat

CAS: 75176-37-3

Zofenoprilat, an angiotensin-converting enzyme (ACE; IC50 = 8 nM for rabbit lung enzyme) inhibitor and the active metabolite of the prodrug zofenopril,

Formula: C₁₅H₁₉NO₃S₂

Color and Shape: Solid

Molecular weight: 325.45

Ref: TM-T83768