CAS 7519-36-0

N-Nitroso-L-proline

Description:

N-Nitroso-L-proline is a chemical compound classified as a nitrosamine, which is a group of compounds known for their potential carcinogenic properties. It is derived from the amino acid L-proline, with a nitroso group (-N=O) attached to the nitrogen atom. This compound is typically a pale yellow solid that is soluble in organic solvents but has limited solubility in water. N-Nitroso-L-proline is of interest in biochemical research due to its role in studies related to cancer and mutagenesis, as nitrosamines can form in biological systems and are associated with various health risks. The compound is also used in laboratory settings to investigate the mechanisms of nitrosation and its effects on biological molecules. Safety precautions are essential when handling this substance, as nitrosamines are generally considered hazardous. Proper storage and disposal methods should be followed to minimize exposure and environmental impact.

Formula: C₅H₈N₂O₃

InChI: InChI=1S/C5H8N2O3/c8-5(9)4-2-1-3-7(4)6-10/h4H,1-3H2,(H,8,9)/t4-/m0/s1

InChI key: InChIKey=WLKPHJWEIIAIFW-BYPYZUCNSA-N

SMILES: N(=O)N1[C@H](C(O)=O)CCC1

Synonyms:

• 1-Nitroso-<span class="text-smallcaps">L</span>-proline
• 1-Nitroso-L-proline
• 1-Nitrosoproline
• <span class="text-smallcaps">L</span>-Proline, 1-nitroso-
• Brn 0473006
• L-Proline, 1-nitroso- (9CI)
• L-Proline, nitroso-
• N-Nitroso-<span class="text-smallcaps">L</span>-proline
• NO-Pro
• Nitrosoproline
• Npro
• Nsc 109545
• Proline, 1-nitroso-, <span class="text-smallcaps">L</span>-
• Proline, 1-nitroso-, L- (8CI)
• Proline, N-nitroso-, L-
• n-Nitrosoproline
• Proline, 1-nitroso-, L-
• L-Proline, 1-nitroso-

N-Nitroso-L-proline

CAS: 7519-36-0

Formula: C₅H₈N₂O₃

Purity: ≥ 98.0%

Color and Shape: Light-yellow to yellow solid

Molecular weight: 144.13

Ref: 7W-GM2942

N-Nitroso-L-Proline

CAS: 7519-36-0

Formula: C₅H₈N₂O₃

Molecular weight: 144.13

Ref: 4Z-P-166061

N-Nitroso-L-proline

CAS: 7519-36-0

Formula: C₅H₈N₂O₃

Molecular weight: 144.13

Ref: ST-EA-CP-NIT275

N-Nitroso-L-proline

Controlled Product

CAS: 7519-36-0

Applications A nitrosoamino acid with oncogenic activity. The LD50 of a single ip dose given to Swiss-Webster mice is 203 +/- 22 mg / kg.
References Nagasawa, H.T., et al.: J. Med. Chem., 16 (5), 583-585 (1973)

Formula: C₅H₈N₂O₃

Color and Shape: Yellow Brown

Molecular weight: 144.13

Ref: TR-N545450

N-Nitroso-L-proline

CAS: 7519-36-0

N-Nitroso-L-proline is a chemical that belongs to the class of bicyclic heterocycles. It can be used in the treatment of HIV infection and cancer, as well as in the study of nitrate metabolism. N-Nitroso-L-proline has been shown to inhibit HIV replication by blocking the reverse transcriptase enzyme, which is essential for viral replication. It also inhibits cancer cells by inhibiting DNA synthesis and protein synthesis in tumor cells. The metabolism of N-nitrosamines has been studied using a model system and a dose group analysis. The nitrosation product, nitrite ion, is oxidized to nitrate ion by acid formation. This process can be monitored through electrochemical impedance spectroscopy (EIS) and histological analyses.

Formula: C₅H₈N₂O₃

Purity: Min. 95%

Color and Shape: Yellow Powder

Molecular weight: 144.13 g/mol

Ref: 3D-FN26370