CAS 75219-46-4

Atrimustine

Description:

Atrimustine, with the CAS number 75219-46-4, is a synthetic compound that belongs to the class of nitrogen mustards, which are known for their alkylating properties. It is primarily characterized by its ability to form covalent bonds with DNA, leading to cross-linking and ultimately inhibiting DNA replication and transcription. This mechanism makes it a candidate for use in cancer therapy, particularly in the treatment of certain types of tumors. Atrimustine is often studied for its potential effectiveness against malignancies, including prostate cancer. In terms of physical properties, it is typically a solid at room temperature and may exhibit moderate solubility in organic solvents. Safety and handling precautions are essential due to its cytotoxic nature, which necessitates careful management in laboratory and clinical settings. As with many alkylating agents, the side effects can include myelosuppression and other toxicities, underscoring the importance of monitoring during therapeutic use. Further research continues to explore its efficacy and safety profile in various treatment regimens.

Formula: C₄₁H₄₇Cl₂NO₆

InChI: InChI=1/C41H47Cl2NO6/c1-41-21-20-34-33-17-15-32(49-40(47)29-7-3-2-4-8-29)26-30(33)12-16-35(34)36(41)18-19-37(41)50-39(46)27-48-38(45)9-5-6-28-10-13-31(14-11-28)44(24-22-42)25-23-43/h2-4,7-8,10-11,13-15,17,26,34-37H,5-6,9,12,16,18-25,27H2,1H3/t34-,35-,36+,37+,41+/m1/s1

InChI key: InChIKey=IFJUINDAXYAPTO-UUBSBJJBSA-N

SMILES: C[C@@]12[C@]([C@]3([C@@](C=4C(CC3)=CC(OC(=O)C5=CC=CC=C5)=CC4)(CC1)[H])[H])(CC[C@@H]2OC(COC(CCCC6=CC=C(N(CCCl)CCCl)C=C6)=O)=O)[H]

Synonyms:

• (17Beta)-17-({[(4-{4-[Bis(2-Chloroethyl)Amino]Phenyl}Butanoyl)Oxy]Acetyl}Oxy)Estra-1,3,5(10)-Trien-3-Yl Benzoate
• 17β-Busramustine
• Bestrabucil
• Estra-1,3,5(10)-triene-3,17-diol (17β)-, 3-benzoate 17-[2-[4-[4-[bis(2-chloroethyl)amino]phenyl]-1-oxobutoxy]acetate]
• Estra-1,3,5(10)-triene-3,17-diol (17β)-, 3-benzoate 17-[[4-[4-[bis(2-chloroethyl)amino]phenyl]-1-oxobutoxy]acetate]
• Estra-1,3,5(10)-triene-3,17-diol (17β)-, 3-benzoate 17-[[4-[4-[bis(2-chloroethyl)amino]phenyl]-1-oxobutoxy]acetate], (3β,5β)-
• Km 2210
• Estra-1,3,5(10)-triene-3,17β-diol 3-benzoate 17-[4-[4-[bis(2-chloroethyl)amino]phenyl]-1-oxobutoxy]acetate
• Bestrabucil (KM2210)

Atrimustine

CAS: 75219-46-4

Atrimustine is a molecule that binds to the cb2 receptor and inhibits the growth of cells in autoimmune diseases. It is also an analog of hydroxyl group and can be used as a diagnostic agent for various types of cancer. Atrimustine has been shown to inhibit the activity of receptors such as the growth factor receptor, fatty acid, colony-stimulating factor, or metabolic disorders. The drug has been found to be biocompatible with polymer implants and may have applications in infectious diseases.

Formula: C₄₁H₄₇Cl₂NO₆

Purity: Min. 95%

Molecular weight: 720.7 g/mol

Ref: 3D-ADA21946

Atrimustine

CAS: 75219-46-4

Atrimustine is a conjugate of chlorambucil and β-estradiol benzoate. It has the antitumor activity.

Formula: C₄₁H₄₇Cl₂NO₆

Purity: 98%

Color and Shape: Solid

Molecular weight: 720.72

Ref: TM-T14344