CAS 75239-91-7

Lithocholic acid 3-glucuronide

Description:

Lithocholic acid 3-glucuronide is a bile acid conjugate formed by the glucuronidation of lithocholic acid, a naturally occurring bile acid involved in the digestion and absorption of fats. This compound is characterized by its hydrophilic properties due to the glucuronide moiety, which enhances its solubility in water compared to its parent bile acid. Lithocholic acid 3-glucuronide plays a significant role in the metabolism and excretion of bile acids, facilitating their elimination from the body. It is typically found in the liver and intestines and can be detected in biological fluids. The compound is of interest in pharmacology and toxicology due to its potential implications in liver function and its association with various metabolic disorders. Additionally, lithocholic acid and its derivatives have been studied for their effects on cellular signaling pathways and their potential roles in health and disease. As with many bile acids, its levels can be influenced by diet, gut microbiota, and liver function.

Formula: C₃₀H₄₈O₉

InChI: InChI=1/C30H48O9/c1-15(4-9-22(31)32)19-7-8-20-18-6-5-16-14-17(10-12-29(16,2)21(18)11-13-30(19,20)3)38-28-25(35)23(33)24(34)26(39-28)27(36)37/h15-21,23-26,28,33-35H,4-14H2,1-3H3,(H,31,32)(H,36,37)/t15-,16-,17+,18+,19-,20+,21+,23+,24+,25-,26+,28-,29+,30-/m1/s1

InChI key: InChIKey=GIQXKAXWRLHLDD-VYACWCJYSA-N

SMILES: C[C@@]12[C@]([C@]3([C@@]([C@]4(C)[C@](CC3)(C[C@H](O[C@@H]5O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]5O)CC4)[H])(CC1)[H])[H])(CC[C@@]2([C@@H](CCC(O)=O)C)[H])[H]

Synonyms:

• Lithocholic acid 3-O-glucuronide
• β-D-Glucopyranosiduronic acid, (3α,5β)-23-carboxy-24-norcholan-3-yl
• Lithocholic acid 3-glucuronide
• (3α,5β)-23-Carboxy-24-norcholan-3-yl β-D-glucopyranosiduronic acid
• Lithocholate 3-O-glucuronide

Lithocholic Acid 3-O-Glucuronide

Controlled Product

CAS: 75239-91-7

Formula: C₃₀H₄₈O₉

Color and Shape: Neat

Molecular weight: 552.7

Ref: TR-L469190

Lithocholic Acid-2,2,3,4,4-d5 3-O-Glucuronide

Controlled Product

CAS: 75239-91-7

Formula: C₃₀H₄₃D₅O₉

Color and Shape: Neat

Molecular weight: 557.73

Ref: TR-L469192

Lithocholic acid 3-o-glucuronide

CAS: 75239-91-7

Lithocholic acid 3-O-glucuronide is a Chinese medicinal compound that has been found to possess potent anticancer properties. It acts as a tumor inhibitor by inducing apoptosis in cancer cells and inhibiting the activity of kinases, which are proteins that play a role in cell growth and division. Lithocholic acid 3-O-glucuronide has been shown to be effective against various types of cancer, and its analogs have been studied extensively for their potential therapeutic uses. This compound is present in urine and can be used as a biomarker for cancer diagnosis and prognosis. The use of kinase inhibitors like Lithocholic acid 3-O-glucuronide represents a promising approach to cancer treatment, offering targeted therapy that can minimize side effects associated with traditional chemotherapy.

Formula: C₃₀H₄₈O₉

Purity: Min. 95%

Molecular weight: 552.7 g/mol

Ref: 3D-ADA23991