CAS 752969-85-0

Riluzole 5-Trifluoromethoxy Isomer

Description:

Riluzole 5-Trifluoromethoxy Isomer, identified by its CAS number 752969-85-0, is a chemical compound that belongs to the class of benzothiazoles and is primarily known for its neuroprotective properties. This substance is a derivative of riluzole, which is used in the treatment of amyotrophic lateral sclerosis (ALS) and other neurodegenerative disorders. The presence of the trifluoromethoxy group enhances its pharmacological activity and solubility. Characteristically, it exhibits a moderate to high lipophilicity, which facilitates its ability to cross the blood-brain barrier. The compound is typically stable under standard conditions but may require specific storage conditions to maintain its integrity. Its mechanism of action involves the modulation of glutamate release, thereby reducing excitotoxicity in neuronal cells. Additionally, the compound's efficacy and safety profile are subjects of ongoing research, particularly in the context of its potential applications in other neurological conditions. Overall, Riluzole 5-Trifluoromethoxy Isomer represents a significant advancement in the pharmacological management of neurodegenerative diseases.

Formula: C₈H₅F₃N₂OS

Synonyms:

• 5-(Trifluoromethoxy)-1,3-benzothiazol-2-amine
• 2-BENZOTHIAZOLAMINE, 5-(TRIFLUOROMETHOXY)-
• Riluzole Impurity 9
• Riluzole 5-Trifluoromethoxy Isomer

5-(Trifluoromethoxy)-2-benzothiazolamine

CAS: 752969-85-0

5-(Trifluoromethoxy)-2-benzothiazolamine

Purity: 98%

Molecular weight: 234.2g/mol

Ref: 54-PC109956

Riluzole 5-Trifluoromethoxy Isomer

Controlled Product

CAS: 752969-85-0

Stability Toxic
Applications Riluzole 5-Trifluoromethoxy Isomer is an impurity of Riluzole (R510000); a neuroprotective agent. Riluzole modulates glutamatergic transmission. It is a glutamate release inhibitor and an anticonvulsant.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Gunakkunru, A., et al.: Asian J. Chem., 19, 2843 (2007); Mizoule, J., et al.: Neuropharmacology, 24, 767 (1985); Wahl, F., et al.: Eur. J. Pharmacol., 230, 209 (1993); Bensimon, G., et al.: N. Engl. J. Med., 330, 585 (1994)

Formula: C₈H₅F₃N₂OS

Color and Shape: Neat

Molecular weight: 234.2

Ref: TR-R510015

5-(Trifluoromethoxy)-2-benzothiazolamine

CAS: 752969-85-0

Purity: 98%

Molecular weight: 234.01

Ref: 10-F556720

Riluzole 5-Trifluoromethoxy Isomer

CAS: 752969-85-0

Formula: C₈H₅F₃N₂OS

Molecular weight: 234.20

Ref: ST-EA-CP-R14002

Riluzole 5-trifluoromethoxy isomer

CAS: 752969-85-0

Riluzole is a compound that inhibits glutamate release. It is used to treat amyotrophic lateral sclerosis (ALS). Riluzole inhibits the release of glutamate, which is an important neurotransmitter in the central nervous system. This drug also has been shown to regulate the influx of calcium into cells, and may have anti-inflammatory properties. Riluzole binds to the alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) receptor and blocks ion channels that are activated by glutamate. In addition, it has been shown to inhibit the activity of caspase 3.

Formula: C₈H₅F₃N₂OS

Purity: Min. 95%

Molecular weight: 234.2 g/mol

Ref: 3D-CFB96985