CAS 75330-75-5: Lovastatin

Description: Lovastatin is a naturally occurring statin, primarily used as a cholesterol-lowering medication. It is derived from the fermentation of the fungus Aspergillus terreus. The chemical structure of lovastatin features a hexahydronaphthalene ring and a lactone moiety, which is crucial for its biological activity. As a competitive inhibitor of HMG-CoA reductase, an enzyme involved in cholesterol biosynthesis, lovastatin effectively reduces levels of low-density lipoprotein (LDL) cholesterol in the bloodstream. It is typically administered orally and is known for its relatively good bioavailability, although it undergoes significant first-pass metabolism in the liver. Lovastatin is also associated with various side effects, including muscle pain and liver enzyme elevation, necessitating regular monitoring during treatment. Additionally, it may interact with other medications, highlighting the importance of a comprehensive medical history before initiation. Overall, lovastatin plays a significant role in managing hyperlipidemia and reducing the risk of cardiovascular diseases.

Formula: C₂₄H₃₆O₅

InChI: InChI=1S/C24H36O5/c1-5-15(3)24(27)29-21-11-14(2)10-17-7-6-16(4)20(23(17)21)9-8-19-12-18(25)13-22(26)28-19/h6-7,10,14-16,18-21,23,25H,5,8-9,11-13H2,1-4H3/t14-,15-,16-,18+,19+,20-,21-,23-/m0/s1

InChI key: InChIKey=PCZOHLXUXFIOCF-BXMDZJJMSA-N

SMILES: O=C1OC(CCC2C(C=CC3=CC(C)CC(OC(=O)C(C)CC)C32)C)CC(O)C1

Synonyms:

• (1S,3R,7S,8S)-8-{2-[(2R,4R)-4-hydroxy-6-oxotetrahydro-2H-pyran-2-yl]ethyl}-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl (2S)-2-methylbutanoate
• (1S,3R,7S,8S,8aR)-8-{2-[(2R,4R)-4-hydroxy-6-oxotetrahydro-2H-pyran-2-yl]ethyl}-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl (2S)-2-methylbutanoate
• 6α-Methylcompactin
• 8-[2-(4-hydroxy-6-oxotetrahydro-2H-pyran-2-yl)ethyl]-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl 2-methylbutanoate
• Altocor
• Altoprev
• Antibiotic MB 530B
• Butanoic acid, 2-methyl-, (1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyl ester, (2S)-
• Butanoic acid, 2-methyl-, 1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-[2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl]-1-naphthalenyl ester, [1S-[1α(R*),3α,7β,8β(2S*,4S*),8aβ]]-
• L 154803
• Lestric
• Lostatin
• Lovacard
• Lovalip
• Lovastatin lactone
• Lovastation
• Lovastin
• Lovex
• Mevacor
• Mevinacor
• Mevinolin
• Mevlor
• Mk 803
• Monacolin K
• Monacolin K lactone
• Msd 803
• Msd803
• NSC 633781
• Oxy)-1-Naphthaleneheptanoicaciddelta-Lactone
• Red Yeast Rice P.E
• Sivlor

Lovastatin

CAS: 75330-75-5

• Formula: C₂₄H₃₆O₅
• Purity: >98.0%(HPLC)
• Color and Shape: White to Light yellow powder to crystal
• Molecular weight: 404.55

Lovastatin, 97%

CAS: 75330-75-5

Lovastatin is a cholesterol lowering drug and competitive inhibitor of HMG-CoA reductase, a rate limiting …

• Formula: C₂₄H₃₆O₅
• Purity: 97%
• Molecular weight: 404.56

Lovastatin CRS

CAS: 75330-75-5

• Formula: C₂₄H₃₆O₅
• Color and Shape: Crystalline Powder. White. Powder.
• Molecular weight: 404.5396

Lovastatin for peak identification CRS

CAS: 75330-75-5

• Formula: C₂₄H₃₆O₅
• Molecular weight: 404.5396

Lovastatin

CAS: 75330-75-5

Lactones nesoi

• Formula: C₂₄H₃₆O₅
• Color and Shape: White Powder
• Molecular weight: 404.54

Lovastatin

CAS: 75330-75-5

Lovastatin (MK-803) is an HMG-CoA reductase inhibitor. Lovastatin lowers cholesterol and is used as a …

• Formula: C₂₄H₃₆O₅
• Purity: 99.59% - 99.72%
• Color and Shape: The Substance Is A White-Yellowish To Yellow Powder Solid Powder
• Molecular weight: 404.54

Lovastatin

CAS: 75330-75-5

• Formula: C₂₄H₃₆O₅
• Purity: (HPLC) ≥ 98.0%
• Color and Shape: White to off-white or faint yellow powder
• Molecular weight: 404.56

Lovastatin

CAS: 75330-75-5

• Purity: 99%+
• Molecular weight: 404.54g/mol

Lovastatin

CAS: 75330-75-5

• Purity: ≥98%
• Molecular weight: 404.54g/mol

Lovastatin

CAS: 75330-75-5

• Formula: C₂₄H₃₆O₅
• Color and Shape: White To Off-White Solid
• Molecular weight: 404.55

Lovastatin, EP grade

CAS: 75330-75-5

• Formula: C₂₄H₃₆O₅
• Purity: 97.0 - 102.0 % (dried substance)
• Color and Shape: White or almost white crystalline powder
• Molecular weight: 404.56

Lovastatin

CAS: 75330-75-5

• Formula: C₂₄H₃₆O₅
• Color and Shape: Neat
• Molecular weight: 404.54

Lovastatin

CAS: 75330-75-5

M02056 - Lovastatin

• Formula: C₂₄H₃₆O₅
• Purity: >95%
• Color and Shape: Solid, White powder
• Molecular weight: 404.5469970703125

Lovastatin

CAS: 75330-75-5

• Formula: C₂₄H₃₆O₅
• Purity: 95%~99%
• Color and Shape: White cryst.
• Molecular weight: 404.547

Lovastatin

CAS: 75330-75-5

• Formula: C₂₄H₃₆O₅
• Color and Shape: Neat
• Molecular weight: 404.54

Lovastatin, 98%

CAS: 75330-75-5

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. …

• Formula: C₂₄H₃₆O₅
• Purity: 98%
• Color and Shape: Powder, White to light yellow
• Molecular weight: 404.55

Lovastatin

CAS: 75330-75-5

• Purity: 99+%
• Color and Shape: Off-White Powder
• Molecular weight: 404.54g/mol

Monacolin k

CAS: 75330-75-5

Lactone

• Formula: C₂₄H₃₆O₅
• Purity: ≥ 90.0 % (HPLC)
• Color and Shape: Powder
• Molecular weight: 404.55

Lovastatin

CAS: 75330-75-5

Impurity Simvastatin EP Impurity E Applications Lovastatin (Simvastatin EP Impurity E) is an antihypercholesterolemic agent. …

• Formula: C₂₄H₃₆O₅
• Color and Shape: White To Light Yellow
• Molecular weight: 404.54

Lovastatin

CAS: 75330-75-5

HMG-CoA reductase inhibitor; mevalonic acid synthesis inhibitor

• Formula: C₂₄H₃₆O₅
• Purity: Min. 98 Area-%
• Color and Shape: White Powder
• Molecular weight: 404.54 g/mol