CAS 75330-75-5

Lovastatin

Description:

Lovastatin is a naturally occurring statin, primarily used as a cholesterol-lowering medication. It is derived from the fermentation of the fungus Aspergillus terreus. The chemical structure of lovastatin features a hexahydronaphthalene ring and a lactone moiety, which is crucial for its biological activity. As a competitive inhibitor of HMG-CoA reductase, an enzyme involved in cholesterol biosynthesis, lovastatin effectively reduces levels of low-density lipoprotein (LDL) cholesterol in the bloodstream. It is typically administered orally and is known for its relatively good bioavailability, although it undergoes significant first-pass metabolism in the liver. Lovastatin is also associated with various side effects, including muscle pain and liver enzyme elevation, necessitating regular monitoring during treatment. Additionally, it may interact with other medications, highlighting the importance of a comprehensive medical history before initiation. Overall, lovastatin plays a significant role in managing hyperlipidemia and reducing the risk of cardiovascular diseases.

Formula: C₂₄H₃₆O₅

InChI: InChI=1S/C24H36O5/c1-5-15(3)24(27)29-21-11-14(2)10-17-7-6-16(4)20(23(17)21)9-8-19-12-18(25)13-22(26)28-19/h6-7,10,14-16,18-21,23,25H,5,8-9,11-13H2,1-4H3/t14-,15-,16-,18+,19+,20-,21-,23-/m0/s1

InChI key: InChIKey=PCZOHLXUXFIOCF-BXMDZJJMSA-N

SMILES: O(C([C@H](CC)C)=O)[C@@H]1[C@]2(C(C=C[C@H](C)[C@@H]2CC[C@@H]3C[C@@H](O)CC(=O)O3)=C[C@H](C)C1)[H]

Synonyms:

• (1S,3R,7S,8S)-8-{2-[(2R,4R)-4-hydroxy-6-oxotetrahydro-2H-pyran-2-yl]ethyl}-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl (2S)-2-methylbutanoate
• (1S,3R,7S,8S,8aR)-8-{2-[(2R,4R)-4-hydroxy-6-oxotetrahydro-2H-pyran-2-yl]ethyl}-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl (2S)-2-methylbutanoate
• 6α-Methylcompactin
• 8-[2-(4-hydroxy-6-oxotetrahydro-2H-pyran-2-yl)ethyl]-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl 2-methylbutanoate
• Altocor
• Altoprev
• Antibiotic MB 530B
• Butanoic acid, 2-methyl-, (1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyl ester, (2S)-
• Butanoic acid, 2-methyl-, 1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-[2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl]-1-naphthalenyl ester, [1S-[1α(R*),3α,7β,8β(2S*,4S*),8aβ]]-
• L 154803
• Lestric
• Lostatin
• Lovacard
• Lovalip
• Lovastatin lactone
• Lovastation
• Lovastin
• Lovex
• Mevacor
• Mevinacor
• Mevinolin
• Mevlor
• Mk 803
• Monacolin K
• Monacolin K lactone
• Msd 803
• Msd803
• NSC 633781
• Oxy)-1-Naphthaleneheptanoicaciddelta-Lactone
• Red Yeast Rice P.E

Lovastatin

CAS: 75330-75-5

Formula: C₂₄H₃₆O₅

Purity: >98.0%(HPLC)

Color and Shape: White to Light yellow powder to crystal

Molecular weight: 404.55

Ref: 3B-L0214

Lovastatin, 97%

CAS: 75330-75-5

Lovastatin is a cholesterol lowering drug and competitive inhibitor of HMG-CoA reductase, a rate limiting enzyme in cholesterol synthesis. Blocks the production of mevalonate, a critical compound in the production of cholesterol and isoprenoids. It increases cellular resistance to anticancer agents

Formula: C₂₄H₃₆O₅

Purity: 97%

Molecular weight: 404.56

Ref: 02-H52792

LOVASTATIN CRS

CAS: 75330-75-5

LOVASTATIN CRS

Formula: C₂₄H₃₆O₅

Color and Shape: Crystalline Powder. White. Powder.

Molecular weight: 404.5396

Ref: 41-L0790000

LOVASTATIN FOR PEAK IDENTIFICATION CRS

CAS: 75330-75-5

LOVASTATIN FOR PEAK IDENTIFICATION CRS

Formula: C₂₄H₃₆O₅

Molecular weight: 404.5396

Ref: 41-Y0001136

Lovastatin

CAS: 75330-75-5

Lactones nesoi

Formula: C₂₄H₃₆O₅

Color and Shape: White Powder

Molecular weight: 404.54

Ref: 45-1370600

Lovastatin

CAS: 75330-75-5

Lovastatin (MK-803) is an HMG-CoA reductase inhibitor. Lovastatin lowers cholesterol and is used as a lipid-lowering agent. Cost-effective and quality-assured.

Formula: C₂₄H₃₆O₅

Purity: 99.66% - 99.92%

Color and Shape: The Substance Is A White-Yellowish To Yellow Powder Solid Powder

Molecular weight: 404.54

Ref: TM-T1207

Lovastatin

CAS: 75330-75-5

Lovastatin

Purity: 99+%

Color and Shape: Off-White Powder

Molecular weight: 404.54g/mol

Ref: 54-BIL1008

Lovastatin

CAS: 75330-75-5

Formula: C₂₄H₃₆O₅

Purity: (HPLC) ≥ 98.0%

Color and Shape: White to off-white or faint yellow powder

Molecular weight: 404.56

Ref: 7W-GP4839

Lovastatin

CAS: 75330-75-5

Lovastatin

Purity: 99%

Molecular weight: 404.54g/mol

Ref: 54-BI12174

Lovastatin

CAS: 75330-75-5

Lovastatin

Purity: ≥98%

Molecular weight: 404.54g/mol

Ref: 54-BUP17172

Lovastatin

CAS: 75330-75-5

Formula: C₂₄H₃₆O₅

Color and Shape: White To Off-White Solid

Molecular weight: 404.55

Ref: 4Z-L-127

Lovastatin, EP grade

CAS: 75330-75-5

Formula: C₂₄H₃₆O₅

Purity: 97.0 - 102.0 % (dried substance)

Color and Shape: White or almost white crystalline powder

Molecular weight: 404.56

Ref: 7W-GP2911

Lovastatin

Controlled Product

CAS: 75330-75-5

Formula: C₂₄H₃₆O₅

Color and Shape: Neat

Molecular weight: 404.54

Ref: 86-MM0050.00

Lovastatin

Controlled Product

CAS: 75330-75-5

Formula: C₂₄H₃₆O₅

Color and Shape: Neat

Molecular weight: 404.54

Ref: 04-C14648500

Lovastatin

CAS: 75330-75-5

Formula: C₂₄H₃₆O₅

Purity: 95%~99%

Color and Shape: White cryst.

Molecular weight: 404.547

Ref: BP-BP3441

Lovastatin

CAS: 75330-75-5

M02056 - Lovastatin

Formula: C₂₄H₃₆O₅

Purity: 95%

Color and Shape: Solid, White powder

Molecular weight: 404.547

Ref: 10-M02056

Monacolin k

CAS: 75330-75-5

Lactone

Formula: C₂₄H₃₆O₅

Purity: ≥ 90.0 % (HPLC)

Color and Shape: Powder

Molecular weight: 404.55

Ref: 5G-80307

Lovastatin

CAS: 75330-75-5

Impurity Simvastatin EP Impurity E
Applications Lovastatin (Simvastatin EP Impurity E) is an antihypercholesterolemic agent. A fungal metabolite, which is a potent inhibitor of HMG-CoA reductase.
References Bilheimer, D.W., et al.: Proc. Nat. Acad. Sci. USA, 80, 4124 (1983),

Formula: C₂₄H₃₆O₅

Color and Shape: White To Light Yellow

Molecular weight: 404.54

Ref: TR-L472225

Simvastatin EP Impurity E

CAS: 75330-75-5

Formula: C₂₄H₃₆O₅

Molecular weight: 404.5

Ref: ST-EA-CP-S4024

Lovastatin - Bio-X ™

CAS: 75330-75-5

Lovastatin is an HMG-CoA reductase inhibitor that is used to lower LDL cholesterol levels and to aid in the management of cardiovascular diseases. Animal studies have demonstrated that this drug has vasculoprotective properties.

Formula: C₂₄H₃₆O₅

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 404.54 g/mol

Ref: 3D-BL164644