CAS 75338-41-9

8-Fluoropefloxacin

Description:

8-Fluoropefloxacin is a synthetic fluoroquinolone antibiotic, characterized by its broad-spectrum antibacterial activity. It is primarily effective against a variety of Gram-negative and some Gram-positive bacteria, making it useful in treating various infections. The chemical structure of 8-Fluoropefloxacin includes a fluorine atom at the 8-position of the quinolone ring, which enhances its potency and spectrum of activity compared to non-fluorinated quinolones. This compound exhibits mechanisms of action that involve the inhibition of bacterial DNA gyrase and topoisomerase IV, enzymes critical for DNA replication and transcription. Additionally, 8-Fluoropefloxacin is known for its favorable pharmacokinetic properties, including good oral bioavailability and tissue penetration. However, like other antibiotics, it may be associated with side effects, including gastrointestinal disturbances and potential effects on the central nervous system. Its use is subject to considerations of bacterial resistance, necessitating careful prescription practices. Overall, 8-Fluoropefloxacin represents an important option in the arsenal against bacterial infections, particularly in cases where resistance to other antibiotics is a concern.

Formula: C₁₇H₁₉F₂N₃O₃

InChI: InChI=1S/C17H19F2N3O3/c1-3-21-9-11(17(24)25)16(23)10-8-12(18)15(13(19)14(10)21)22-6-4-20(2)5-7-22/h8-9H,3-7H2,1-2H3,(H,24,25)

InChI key: InChIKey=RAOISAYCLQDOND-UHFFFAOYSA-N

SMILES: C(C)N1C=2C(C(=O)C(C(O)=O)=C1)=CC(F)=C(C2F)N3CCN(C)CC3

Synonyms:

• 1-Ethyl-6,8-difluoro-1,4-dihydro-7-(4-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid
• 3-Quinolinecarboxylic Acid, 1-Ethyl-6,8-Difluoro-1,4-Dihydro-7-(4-Methyl-1-Piperazinyl)-4-Oxo-
• 8-Fluoropefloxacin
• 1-Ethyl-6,8-difluoro-7-(4-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid