CAS 753499-14-8

NS 6740

CAS: 753499-14-8

α7 nAChR partial agonist with high affinity (Ki = 1.1 nM), inhibits ACh at α7 nAChR (IC50 = 2.7 nM), anti-inflammatory, reduces microglial TNF-α.

Formula: C₁₉H₂₀ClF₃N₂O₂

Color and Shape: Solid

Molecular weight: 400.83

Ref: TM-T37390

NS 6740

Controlled Product

CAS: 753499-14-8

A weak partial agonist of α7 nicotinic acetylcholine receptors (nAChR) that strongly desensitizes the activity of this ion channel. Functions by converting the mode of α7 signaling to a channel-independent mode, causing reduced synapses.  Suppresses cognitive functions and inhibits α7 activators that enhance cognition. Elicits anti-inflammatory effects, by reducing LPS-mediated TNFα release.

Formula: C₁₉H₁₉F₃N₂O₂

Purity: Min. 95%

Color and Shape: Off-White To Yellow Solid

Molecular weight: 364.36 g/mol

Ref: 3D-BN166517