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CAS 75498-93-0

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BOC-D-HIS(BOC)-OH

Description:
BOC-D-HIS(BOC)-OH, also known as Nα,Nα-Bis(benzyloxycarbonyl)-L-histidine, is a protected form of the amino acid histidine, commonly used in peptide synthesis and biochemistry. This compound features two benzyloxycarbonyl (BOC) protecting groups, which serve to shield the amino and carboxyl functional groups during chemical reactions, thereby preventing unwanted side reactions. The presence of the histidine side chain, which contains an imidazole ring, allows for unique interactions, such as metal ion coordination and protonation, making it valuable in various biochemical applications. BOC-D-HIS(BOC)-OH is typically a white to off-white solid and is soluble in organic solvents like dichloromethane and dimethylformamide, but less soluble in water. Its stability under standard laboratory conditions makes it suitable for use in peptide synthesis, where it can be deprotected to yield functional histidine residues in peptides. Proper handling and storage are essential, as with many chemical substances, to maintain its integrity and reactivity.
Formula:C16H25N3O6
Synonyms:
  • N,1-Bis-Boc-D-histidine
  • N-ALPHA,N-IM-DI-T-BUTOXYCARBONYL-D-HISTIDINE
  • 1,Nα-bis-tert-butoxycarbonyl-histidine
  • D-Histidine, N,1-bis[(1,1-dimethylethoxy)carbonyl]-
  • N,1-Bis[(1,1-dimethylethoxy)carbonyl]-D-histidine
  • BOC-D-HIS(BOC)-OH
  • Nα,Nim-Bis-Boc-D-histidine benzene
  • (R)-3-(1-(tert-Butoxycarbonyl)-1H-imidazol-4-yl)-2-((tert-butoxycarbonyl)amino)propanoic acid
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