CAS 755038-02-9

BI 2536

Description:

BI 2536 is a small molecule inhibitor primarily known for its role as a selective inhibitor of the enzyme polo-like kinase 1 (PLK1), which is crucial for cell division and proliferation. This compound is characterized by its ability to induce cell cycle arrest and apoptosis in cancer cells, making it a subject of interest in cancer research and therapy. BI 2536 has demonstrated efficacy against various cancer types in preclinical studies, particularly in those with high PLK1 expression. The substance is typically administered in a pharmaceutical formulation and has been evaluated in clinical trials for its potential to enhance the effectiveness of existing cancer treatments. Its chemical structure features a complex arrangement that contributes to its specificity and potency as a PLK1 inhibitor. As with many investigational drugs, the safety profile and side effects are important considerations in its development and application in oncology. Overall, BI 2536 represents a promising avenue in targeted cancer therapy, focusing on the modulation of key regulatory pathways in tumor cells.

Formula: C₂₈H₃₉N₇O₃

InChI: InChI=1S/C28H39N7O3/c1-5-22-27(37)34(3)23-17-29-28(32-25(23)35(22)20-8-6-7-9-20)31-21-11-10-18(16-24(21)38-4)26(36)30-19-12-14-33(2)15-13-19/h10-11,16-17,19-20,22H,5-9,12-15H2,1-4H3,(H,30,36)(H,29,31,32)/t22-/m1/s1

InChI key: InChIKey=XQVVPGYIWAGRNI-JOCHJYFZSA-N

SMILES: C(C)[C@H]1N(C=2C(N(C)C1=O)=CN=C(NC3=C(OC)C=C(C(NC4CCN(C)CC4)=O)C=C3)N2)C5CCCC5

Synonyms:

• (R)-4-[(8-Cyclopentyl-7-ethyl-5,6,7,8-tetrahydro-5-methyl-6-oxo-2-pteridinyl)amino]-3-methoxy-N-(1-methyl-4-piperidinyl)benzamide
• 4-[[(7R)-8-Cyclopentyl-7-ethyl-5,6,7,8-tetrahydro-5-methyl-6-oxo-2-pteridinyl]amino]-3-methoxy-N-(1-methyl-4-piperidinyl)benzamide
• Benzamide, 4-(((7R)-8-cyclopentyl-7-ethyl-5,6,7,8-tetrahydro-5-methyl-6-oxo-2-pteridinyl)amino)-3-methoxy-N-(1-methyl-4-piperidinyl)-
• Bi 2356
• Bi2536
• BI 2536

BI 2536

CAS: 755038-02-9

Formula: C₂₈H₃₉N₇O₃

Purity: 98%

Color and Shape: Solid

Molecular weight: 521.6544

Ref: IN-DA00G2LA

(R)-4-((8-Cyclopentyl-7-Ethyl-5-Methyl-6-Oxo-5,6,7,8-Tetrahydropteridin-2-Yl)Amino)-3-Methoxy-N-(1-Methylpiperidin-4-Yl)Benzamide

CAS: 755038-02-9

(R)-4-((8-Cyclopentyl-7-Ethyl-5-Methyl-6-Oxo-5,6,7,8-Tetrahydropteridin-2-Yl)Amino)-3-Methoxy-N-(1-Methylpiperidin-4-Yl)Benzamide

Purity: 98%

Molecular weight: 521.65g/mol

Ref: 54-OR1023191

BI 2536

CAS: 755038-02-9

BI 2536

Purity: ≥98%

Molecular weight: 521.65g/mol

Ref: 54-BUP08614

(R)-BI-2536

CAS: 755038-02-9

Ref: 7W-GW0676

BI 2536

CAS: 755038-02-9

BI2536 is an effective Plk1 inhibitor (IC50: 0.83 nM). It has 4- and 11-fold greater selectivity than Plk2 and Plk3.

Formula: C₂₈H₃₉N₇O₃

Purity: 98% - 99.88%

Color and Shape: Solid

Molecular weight: 521.65

Ref: TM-T6173

BI 2536

CAS: 755038-02-9

BI 2536 is a protein kinase inhibitor that specifically blocks the activity of the protein Bcl-2-interacting killer (BIK) by binding to its ATP-binding site. It has been shown to induce apoptosis in cancer cells, including squamous cell carcinoma and HL60 cells. BI 2536 inhibits tumor growth in mice with solid tumours, such as sarcomas and carcinomas, by inducing autophagy. This drug also has an anti-inflammatory effect against mouse tumors through Toll-like receptor 9 activation. BI 2536 induces programmed cell death in cancer tissues by inhibiting the expression of the Mcl-1 protein.

Formula: C₂₈H₃₉N₇O₃

Purity: Min. 95%

Molecular weight: 521.65 g/mol

Ref: 3D-FFB03802