CAS 75523-11-4

(3R,4R,5R,6R)-6-[2-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-indol-3-yl]acetyl]oxy-3,4,5-trihydroxy-tetrahydropyran-2-carboxylic acid

Description:

The chemical substance with the name "(3R,4R,5R,6R)-6-[2-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-indol-3-yl]acetyl]oxy-3,4,5-trihydroxy-tetrahydropyran-2-carboxylic acid" and CAS number "75523-11-4" is a complex organic compound characterized by its intricate molecular structure, which includes multiple functional groups such as hydroxyl (-OH), carboxylic acid (-COOH), and an acetoxy moiety. This compound features a tetrahydropyran ring, which contributes to its cyclic nature and stereochemistry, indicated by the specific R configurations at several carbon centers. The presence of a chlorobenzoyl group and a methoxy group suggests potential biological activity, possibly influencing its solubility and reactivity. The compound's trihydroxy and carboxylic acid functionalities may enhance its interaction with biological targets, making it of interest in medicinal chemistry. Overall, its structural complexity and functional diversity imply potential applications in pharmaceuticals or as a biochemical probe, although specific biological activities would require further investigation.

Formula: C₂₅H₂₄ClNO₁₀

InChI: InChI=1/C25H24ClNO10/c1-11-15(10-18(28)36-25-21(31)19(29)20(30)22(37-25)24(33)34)16-9-14(35-2)7-8-17(16)27(11)23(32)12-3-5-13(26)6-4-12/h3-9,19-22,25,29-31H,10H2,1-2H3,(H,33,34)/t19-,20-,21-,22?,25+/m1/s1

Synonyms:

• INDOMETHACIN ACYL-B-D-GLUCURONIDE
• 1-[1-(4-Chlorobenzoyl)-5-Methoxy-2-Methyl-1H-indole-3-acetate] β-D-Glucopyranuronic Acid
• Indomethacin Acyl--D-glucuronide
• Indometacin-acyl-beta-D-glucuronide
• Indomethacin-acyl-beta-D-glucuronide min. 95%
• Indomethacin acyl-β-D-glucuronide ,98%
• IndoMethacin Glucuronide

Indomethacin acyl-b-D-glucuronide

CAS: 75523-11-4

Formula: C₂₅H₂₄ClNO₁₀

Purity: ≥ 95.0%

Color and Shape: Pale yellow to green crystalline powder

Molecular weight: 533.91

Ref: 7W-GC0423

Indomethacin-acyl-β-D-glucuronide

CAS: 75523-11-4

Indomethacin-acyl-β-D-glucuronide

Purity: >95%

Molecular weight: 533.91g/mol

Ref: 54-BICL4112

Indomethacin acyl-b-D-glucuronide

CAS: 75523-11-4

Indomethacin acyl-b-D-glucuronide is a prodrug of indomethacin. It is absorbed through the stomach and small intestine and metabolized in the liver. The pharmacokinetic parameters are not as well understood as with other drugs, but it has been shown that indomethacin acyl-b-D-glucuronide has a higher systemic exposure than indomethacin. This may be due to an increase in absorption or faster elimination. Indomethacin acyl-b-D-glucuronide is used for the treatment of pain and inflammation associated with rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, gouty arthritis, and bursitis.

Formula: C₂₅H₂₄ClNO₁₀

Purity: Min. 95 Area-%

Color and Shape: Yellow Powder

Molecular weight: 533.91 g/mol

Ref: 3D-MI07430

Indomethacin Acyl-β-D-glucuronide (>90%)

Controlled Product

CAS: 75523-11-4

Applications Indomethacin Acyl-β-D-glucuronide is a metabolite of Indomethacin (I641000). Acyl glucuronides have been implicated in the toxicity of many xenobiotics and marketed drugs.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Abid, A., et al.: Biochem. Pharmacol., 50, 557 (1995), Gamage, N., et al.: Toxicol. Sci., 90, 5 (2006), Cerveny, L., et al.: Drug Metab. Dispos., 35, 1032 (2007), Hayeshi, R., et al.: Eur. J. Pharm. Sci., 35, 383 (2008),

Formula: C₂₅H₂₄ClNO₁₀

Color and Shape: Neat

Molecular weight: 533.91

Ref: TR-I641010

Indomethacin Acyl Glucuronide

CAS: 75523-11-4

Formula: C₂₅H₂₄ClNO₁₀

Molecular weight: 533.91

Ref: ST-EA-CP-I7026

Indomethacin Acyl Glucuronide

CAS: 75523-11-4

Indomethacin acyl glucuronide, a metabolite of the COX inhibitor indomethacin (1), embodies an essential byproduct formed during the metabolic processing of indomethacin.

Formula: C₂₅H₂₄ClNO₁₀

Color and Shape: Solid

Molecular weight: 533.91

Ref: TM-T84973