CAS 75567-37-2
:Ingenol mebutate
Description:
Ingenol mebutate is a synthetic compound derived from the sap of the Euphorbia peplus plant, known for its use in dermatological applications, particularly in the treatment of actinic keratosis. It is classified as a diterpenoid and exhibits a unique mechanism of action that involves inducing cell death in abnormal keratinocytes while also promoting an inflammatory response that aids in the clearance of these cells. Ingenol mebutate is typically formulated as a topical gel, allowing for localized treatment. The compound has a relatively short half-life, which contributes to its safety profile, as systemic absorption is minimal. Its efficacy is attributed to its ability to activate protein kinase C, leading to apoptosis and subsequent immune-mediated responses. Ingenol mebutate is generally well-tolerated, though some patients may experience local skin reactions such as erythema, crusting, or peeling. Overall, it represents a novel approach in the management of precancerous skin lesions, providing a convenient and effective option for patients.
Formula:C25H34O6
InChI:InChI=1S/C25H34O6/c1-7-12(2)22(29)31-21-13(3)10-24-14(4)8-17-18(23(17,5)6)16(20(24)28)9-15(11-26)19(27)25(21,24)30/h7,9-10,14,16-19,21,26-27,30H,8,11H2,1-6H3/b12-7-/t14-,16+,17-,18+,19-,21+,24+,25+/m1/s1
InChI key:InChIKey=VDJHFHXMUKFKET-WDUFCVPESA-N
SMILES:O[C@@]12[C@@]3(C(=O)[C@]([C@]4([C@@](C[C@H]3C)(C4(C)C)[H])[H])(C=C(CO)[C@H]1O)[H])C=C(C)[C@@H]2OC(/C(=C\C)/C)=O
Synonyms:- 1H-2,8a-Methanocyclopenta[a]cyclopropa[e]cyclodecene, 2-butenoic acid deriv.
- 2-Butenoic acid, 2-methyl-, (1aR,2S,5R,5aS,6S,8aS,9R,10aR)-1a,2,5,5a,6,9,10,10a-octahydro-5,5a-dihydroxy-4-(hydroxymethyl)-1,1,7,9-tetramethyl-11-oxo-1H-2,8a-methanocyclopenta[a]cyclopropa[e]cyclodecen-6-yl ester, (2Z)-
- 2-Butenoic acid, 2-methyl-, 1a,2,5,5a,6,9,10,10a-octahydro-5,5a-dihydroxy-4-(hydroxymethyl)-1,1,7,9-tetramethyl-11-oxo-1H-2,8a-methanocyclopenta[a]cyclopropa[e]cyclodecen-6-yl ester, [1aR-[1aα,2β,5β,5aβ,6β(Z),8aα,9α,10aα]]-
- 3-Angeloylingenol
- Aids-416619
- Aids416619
- Euphorbia factor An<sub>1</sub>
- Euphorbia factor H<sub>1</sub>
- I3A
- Ingenol 3-angelate
- Ingenol 3-mebutate
- Ingenol mebutate
- Pep 005
- Picato
- See more synonyms
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Found 8 products.
Ingenol mebutate
CAS:<p>Ingenol mebutate activates PKC-α, -β, -γ, -δ, -ε (Kis 0.105-0.376 nM), has anti-inflammatory and antitumor effects.</p>Formula:C25H34O6Purity:99.76%Color and Shape:SolidMolecular weight:430.53Ingenol Mebutate
CAS:Ingenol-3-angelate shows anticancer activity, and P-gp-mediated absorptive transport, dermal penetration, and vascular damage contribute to the anticancer activity of ingenol-3-angelate in vivo; it activates a broad range of PKC isoforms and induces apoptosis in acute myeloid leukemia cells by activating the PKC isoform PKCdelta. Ingenol-3-angelate suppresses HIV infection of primary CD4+ T cells through down-modulation of cell surface expression of HIV co-receptors. Ingenol-3-angelate emerges as a unique local chemotherapeutic immunostimulatory debulking agent that could be used in conjunction with immunotherapies to promote regression of metastases.Formula:C25H34O6Purity:95%~99%Molecular weight:430.541Ingenol 3-Angelate
CAS:Controlled Product<p>Applications Ingenol 3-Angelate is known to exhibit antitumor activities which induces plasma membrane and mitochondrial disruption and necrotic cell death.<br>References Ogbourne, S.M., et al.: Cancer. Res., 64, 2833 (2004); Zayed, S.M., et al.: J. Cancer. Res. Clin. Oncol., 127, 40 (2001);<br></p>Formula:C25H34O6Color and Shape:NeatMolecular weight:430.53
