CAS 75567-37-2: Ingenol mebutate

Description: Ingenol mebutate is a synthetic compound derived from the sap of the Euphorbia peplus plant, known for its use in dermatological applications, particularly in the treatment of actinic keratosis. It is classified as a diterpenoid and exhibits a unique mechanism of action that involves inducing cell death in abnormal keratinocytes while also promoting an inflammatory response that aids in the clearance of these cells. Ingenol mebutate is typically formulated as a topical gel, allowing for localized treatment. The compound has a relatively short half-life, which contributes to its safety profile, as systemic absorption is minimal. Its efficacy is attributed to its ability to activate protein kinase C, leading to apoptosis and subsequent immune-mediated responses. Ingenol mebutate is generally well-tolerated, though some patients may experience local skin reactions such as erythema, crusting, or peeling. Overall, it represents a novel approach in the management of precancerous skin lesions, providing a convenient and effective option for patients.

Formula: C₂₅H₃₄O₆

InChI: InChI=1S/C25H34O6/c1-7-12(2)22(29)31-21-13(3)10-24-14(4)8-17-18(23(17,5)6)16(20(24)28)9-15(11-26)19(27)25(21,24)30/h7,9-10,14,16-19,21,26-27,30H,8,11H2,1-6H3/b12-7-/t14-,16+,17-,18+,19-,21+,24+,25+/m1/s1

InChI key: InChIKey=VDJHFHXMUKFKET-WDUFCVPESA-N

SMILES: O=C(OC1C(=CC23C(=O)C(C=C(CO)C(O)C12O)C4C(CC3C)C4(C)C)C)C(=CC)C

Synonyms:

• 1H-2,8a-Methanocyclopenta[a]cyclopropa[e]cyclodecene, 2-butenoic acid deriv.
• 2-Butenoic acid, 2-methyl-, (1aR,2S,5R,5aS,6S,8aS,9R,10aR)-1a,2,5,5a,6,9,10,10a-octahydro-5,5a-dihydroxy-4-(hydroxymethyl)-1,1,7,9-tetramethyl-11-oxo-1H-2,8a-methanocyclopenta[a]cyclopropa[e]cyclodecen-6-yl ester, (2Z)-
• 2-Butenoic acid, 2-methyl-, 1a,2,5,5a,6,9,10,10a-octahydro-5,5a-dihydroxy-4-(hydroxymethyl)-1,1,7,9-tetramethyl-11-oxo-1H-2,8a-methanocyclopenta[a]cyclopropa[e]cyclodecen-6-yl ester, [1aR-[1aα,2β,5β,5aβ,6β(Z),8aα,9α,10aα]]-
• 3-Angeloylingenol
• Aids-416619
• Aids416619
• Euphorbia factor An₁
• Euphorbia factor H₁
• I3A
• Ingenol 3-angelate
• Ingenol 3-mebutate
• Ingenol mebutate
• Pep 005
• Picato
• Euphorbia factor An1

Ingenol-3-angelate

CAS: 75567-37-2

• Formula: C₂₅H₃₄O₆
• Purity: 98%
• Color and Shape: Solid
• Molecular weight: 430.5338599999999

Ingenol mebutate

CAS: 75567-37-2

• Purity: ≥98%
• Molecular weight: 430.53g/mol

Ingenol mebutate

CAS: 75567-37-2

Ingenol mebutate activates PKC-α, -β, -γ, -δ, -ε (Kis 0.105-0.376 nM), has anti-inflammatory and antitumor …

• Formula: C₂₅H₃₄O₆
• Purity: 99.04%
• Color and Shape: Solid
• Molecular weight: 430.53

Ingenol Mebutate

CAS: 75567-37-2

Ingenol-3-angelate shows anticancer activity, and P-gp-mediated absorptive transport, dermal penetration, and vascular damage contribute to …

• Formula: C₂₅H₃₄O₆
• Purity: 95%~99%
• Molecular weight: 430.541

Ingenol-3-angelate

CAS: 75567-37-2

• Formula: C₂₅H₃₄O₆
• Molecular weight: 430.5

Ingenol mebutate

CAS: 75567-37-2

• Formula: C₂₅H₃₄O₆
• Molecular weight: 430.58

Ingenol 3-Angelate

CAS: 75567-37-2

Applications Ingenol 3-Angelate is known to exhibit antitumor activities which induces plasma membrane and mitochondrial …

• Formula: C₂₅H₃₄O₆
• Color and Shape: Neat
• Molecular weight: 430.53

Ingenol-3-angelate

CAS: 75567-37-2

Ingenol-3-angelate (ING) is a natural compound that induces apoptosis in cancer cells by inhibiting mitochondrial …

• Formula: C₂₅H₃₄O₆
• Purity: Min. 95%
• Color and Shape: White To Off-White Solid
• Molecular weight: 430.53 g/mol