CAS 75607-67-9: Fludarabine phosphate
Description:Fludarabine phosphate is an antineoplastic agent primarily used in the treatment of certain types of leukemia, particularly chronic lymphocytic leukemia (CLL) and non-Hodgkin lymphoma. It is a purine analog, specifically a derivative of adenosine, which interferes with DNA synthesis and repair, ultimately leading to cell death. The compound is typically administered intravenously and is known for its ability to penetrate cell membranes effectively due to its phosphate ester form, which enhances its solubility. Fludarabine phosphate exhibits a relatively short half-life, necessitating careful dosing and monitoring during treatment. Common side effects include myelosuppression, immunosuppression, and gastrointestinal disturbances. Its mechanism of action involves the inhibition of DNA polymerase and ribonucleotide reductase, disrupting the proliferation of malignant cells. As a chemotherapeutic agent, it is often used in combination with other drugs to enhance therapeutic efficacy. Due to its potent effects, fludarabine phosphate is classified as a hazardous drug, requiring appropriate handling and disposal measures in clinical settings.
Formula:C10H13FN5O7P
InChI:InChI=1S/C10H13FN5O7P/c11-10-14-7(12)4-8(15-10)16(2-13-4)9-6(18)5(17)3(23-9)1-22-24(19,20)21/h2-3,5-6,9,17-18H,1H2,(H2,12,14,15)(H2,19,20,21)/t3-,5-,6+,9-/m1/s1
InChI key:InChIKey=GIUYCYHIANZCFB-FJFJXFQQSA-N
SMILES:O=P(O)(O)OCC1OC(N2C=NC=3C(=NC(F)=NC32)N)C(O)C1O
- Synonyms:
- 9-bata-D-Arabinofuranosyl-2-fluoroadenine phosphate
- 9H-Purin-6-amine, 2-fluoro-9-(5-O-phosphono-β-D-arabinofuranosyl)-
- 9-b-D-Arabinofuranosyl-2-fluoroadenine-5-(dihydrogen phosphate)
- 2-Fluoro-9-(5-O-phosphono-β-D-arabinofuranosyl)-9H-purin-6-amine
- Fludarabine phosphate
- Fludarabin Phosphate
- NSC 312887
- NSC 328002
- 9-beta-arabinofuranosyl-2-fluoroadenine-5'-phosphate
- 2-fluoro-9-(5-O-phosphono-beta-D-arabinofuranosyl)-9H-purin-6-amine
- See more synonyms
- 9-β-Arabinofuranosyl-2-fluoroadenine-5'-monophosphate
- 2-fluoro-9-(5-O-phosphonopentofuranosyl)-9H-purin-6-amine
- 2-Fluoro-9-(5-O-phosphono-β-D-arabinofuranosyl)-9H-purin-6-amine
