CAS 75607-67-9

Fludarabine phosphate

Description:

Fludarabine phosphate is an antineoplastic agent primarily used in the treatment of certain types of leukemia, particularly chronic lymphocytic leukemia (CLL) and non-Hodgkin lymphoma. It is a purine analog, specifically a derivative of adenosine, which interferes with DNA synthesis and repair, ultimately leading to cell death. The compound is typically administered intravenously and is known for its ability to penetrate cell membranes effectively due to its phosphate ester form, which enhances its solubility. Fludarabine phosphate exhibits a relatively short half-life, necessitating careful dosing and monitoring during treatment. Common side effects include myelosuppression, immunosuppression, and gastrointestinal disturbances. Its mechanism of action involves the inhibition of DNA polymerase and ribonucleotide reductase, disrupting the proliferation of malignant cells. As a chemotherapeutic agent, it is often used in combination with other drugs to enhance therapeutic efficacy. Due to its potent effects, fludarabine phosphate is classified as a hazardous drug, requiring appropriate handling and disposal measures in clinical settings.

Formula: C₁₀H₁₃FN₅O₇P

InChI: InChI=1S/C10H13FN5O7P/c11-10-14-7(12)4-8(15-10)16(2-13-4)9-6(18)5(17)3(23-9)1-22-24(19,20)21/h2-3,5-6,9,17-18H,1H2,(H2,12,14,15)(H2,19,20,21)/t3-,5-,6+,9-/m1/s1

InChI key: InChIKey=GIUYCYHIANZCFB-FJFJXFQQSA-N

SMILES: NC1=C2C(N(C=N2)[C@@H]3O[C@H](COP(=O)(O)O)[C@@H](O)[C@@H]3O)=NC(F)=N1

Synonyms:

• 9-bata-D-Arabinofuranosyl-2-fluoroadenine phosphate
• 9H-Purin-6-amine, 2-fluoro-9-(5-O-phosphono-β-D-arabinofuranosyl)-
• 9-b-D-Arabinofuranosyl-2-fluoroadenine-5-(dihydrogen phosphate)
• 2-Fluoro-9-(5-O-phosphono-β-D-arabinofuranosyl)-9H-purin-6-amine
• Fludarabine phosphate
• Fludarabin Phosphate
• NSC 312887
• NSC 328002
• 9-beta-arabinofuranosyl-2-fluoroadenine-5'-phosphate
• 2-fluoro-9-(5-O-phosphono-beta-D-arabinofuranosyl)-9H-purin-6-amine
• 9-β-Arabinofuranosyl-2-fluoroadenine-5'-monophosphate
• 2-fluoro-9-(5-O-phosphonopentofuranosyl)-9H-purin-6-amine

Fludarabine Monophosphate

CAS: 75607-67-9

Formula: C₁₀H₁₃FN₅O₇P

Purity: >98.0%(T)(HPLC)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 365.21

Ref: 3B-F0913

FLUDARABINE FOR SYSTEM SUITABILITY CRS

CAS: 75607-67-9

FLUDARABINE FOR SYSTEM SUITABILITY CRS

Ref: 41-Y0001536

Fludarabine phosphate

CAS: 75607-67-9

Fludarabine phosphate

Formula: C₁₀H₁₃FN₅O₇P

Purity: 97.8%

Color and Shape: White. To. Off-White

Molecular weight: 365.05366

Ref: 47-1321

FLUDARABINE PHOSPHATE CRS

CAS: 75607-67-9

FLUDARABINE PHOSPHATE CRS

Formula: C₁₀H₁₃FN₅O₇P

Color and Shape: Added Added

Molecular weight: 365.2117

Ref: 41-Y0000419

FLUDARABINE FOR PEAK IDENTIFICATION CRS

CAS: 75607-67-9

FLUDARABINE FOR PEAK IDENTIFICATION CRS

Ref: 41-Y0002256

Fludarabine Phosphate

CAS: 75607-67-9

Nucleic acids and their salts, whether or not chemically defined; other heterocyclic compounds, nesoi

Formula: C₁₀H₁₃FN₅O₇P

Color and Shape: White Crystalline Powder

Molecular weight: 365.05366

Ref: 45-1272204

{[(2R,3S,4S,5R)-5-(6-amino-2-fluoro-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}phosphonic acid

CAS: 75607-67-9

Formula: C₁₀H₁₃FN₅O₇P

Purity: 98%

Color and Shape: Solid

Molecular weight: 365.2117

Ref: IN-DA00ICN9

Fludarabine Phosphate

CAS: 75607-67-9

Fludarabine Phosphate

Purity: 98%

Molecular weight: 365.21g/mol

Ref: 54-PC109175

Fludarabine Phosphate

CAS: 75607-67-9

Fludarabine Phosphate

Purity: ≥98%

Molecular weight: 365.21g/mol

Ref: 54-BUP15559

Fludarabine Phosphate

CAS: 75607-67-9

Formula: C₁₀H₁₃FN₅O₇P

Color and Shape: White To Off-White Solid

Molecular weight: 365.22

Ref: 4Z-F-588

Fludarabine phosphate, USP

CAS: 75607-67-9

Formula: C₁₀H₁₃FN₅O₇P

Purity: ≤ 0.1%

Color and Shape: White powder

Molecular weight: 365.21

Ref: 7W-GP3476

Fludarabine Phosphate

CAS: 75607-67-9

Color and Shape: White To Off-White

Ref: 86-MM3428.00

Fludarabine Phosphate

CAS: 75607-67-9

Fludarabine Phosphate (NSC 312887 Phosphate) is a fluorinated nucleotide antimetabolite analog of the antiviral agent vidarabine with antineoplastic activity.

Formula: C₁₀H₁₃FN₅O₇P

Purity: 99.25% - 99.78%

Color and Shape: Solid

Molecular weight: 365.21

Ref: TM-T6501

Fludarabine phosphate

CAS: 75607-67-9

Formula: C₁₀H₁₃FN₅O₇P

Purity: ≥ 98.0%

Color and Shape: White to almost white powder

Molecular weight: 365.21

Ref: 7W-GP0418

Fludarabine phosphate

CAS: 75607-67-9

Purity: 98%

Molecular weight: 365.21

Ref: 10-F792862

Fludarabine Phosphate

Controlled Product

CAS: 75607-67-9

Applications 4-Desfluoro-4-(1,2,4-triazol-1-yl)phenyl Fluconazole is an impurity in the synthesis of Fluconazole (F421000), used as an antifungal.
References Richard, K. et al.: Antimicrob. Ag. Chemother., 27, 832 (1985);

Formula: C₁₀H₁₃FN₅O₇P

Color and Shape: White To Off-White

Molecular weight: 365.21

Ref: TR-F425005

Fludarabine phosphate

CAS: 75607-67-9

Fludarabine phosphate is an antileukemic drug that inhibits DNA polymerase α and β, as well as other enzymes in the nucleotide synthesis pathway. It is used to treat patients with chronic myelogenous leukemia (CML) who have developed resistance to other treatments. Fludarabine phosphate has been shown to induce a cytotoxic effect against tumor cells by binding to ATP-binding cassette transporter proteins on the cell membrane and inhibiting intracellular targets such as DNA, RNA, and protein synthesis. Fludarabine phosphate has also been shown to inhibit the growth of tumor cells through synergistic interactions with other anticancer drugs such as hydroxyurea or busulfan, which may be due to its ability to inhibit enzyme activities such as erythrocyte alkaline phosphatase.

Formula: C₁₀H₁₃FN₅O₇P

Purity: Min. 98 Area-%

Color and Shape: Powder

Molecular weight: 365.21 g/mol

Ref: 3D-NF01485