Suc-Phe-Pro-Phe-pNA, also known as Succinyl-L-phenylalanine-L-proline-L-phenylalanine-p-nitroanilide, is a synthetic peptide substrate commonly used in biochemical assays, particularly for the study of proteolytic enzymes. This compound features a succinyl group that enhances its solubility and stability, while the phenylalanine and proline residues contribute to its specificity for certain enzymes, such as serine proteases. The p-nitroanilide moiety serves as a chromogenic indicator, allowing for the quantification of enzyme activity through colorimetric changes upon cleavage by the enzyme. Suc-Phe-Pro-Phe-pNA is typically utilized in laboratory settings to monitor enzyme kinetics and to assess the activity of proteases in various biological samples. Its characteristics include being a white to off-white powder, soluble in water, and stable under appropriate storage conditions. As with many peptide substrates, it is important to handle it with care, following safety protocols to avoid exposure.

Suc-Phe-Pro-Phe-pNA

75651-68-2: Suc-Phe-Pro-Phe-pNA, also known as Succinyl-L-phenylalanine-L-proline-L-phenylalanine-p-nitroanilide, is a synthetic peptide substrate commonly used in biochemical assays, particularly for the study of proteolytic enzymes. This compound features a succinyl group that enhances its solubility and stability, while the phenylalanine and proline residues contribute to its specificity for certain enzymes, such as serine proteases. The p-nitroanilide moiety serves as a chromogenic indicator, allowing for the quantification of enzyme activity through colorimetric changes upon cleavage by the enzyme. Suc-Phe-Pro-Phe-pNA is typically utilized in laboratory settings to monitor enzyme kinetics and to assess the activity of proteases in various biological samples. Its characteristics include being a white to off-white powder, soluble in water, and stable under appropriate storage conditions. As with many peptide substrates, it is important to handle it with care, following safety protocols to avoid exposure.

<p>Suc-Phe-Pro-Phe-pNA is a peptide that has been shown to inhibit the effector functions of anisopliae. The molecule is synthesized by attaching a chloromethyl ketone to the carboxy terminal amino acid. This process is specific for only one sequence and can be used in metarhizium, which is a fungus that naturally occurs in soil and decomposing organic matter. Suc-Phe-Pro-Phe-pNA has been shown to be reactive with inflammatory diseases such as asthma, arthritis, and atherosclerosis. The molecule's activity may be due to its acidic nature or high salt content at its reactive site. This peptide also has a pH optimum range of 3–5, which may contribute to its activity as well.</p>

CAS 75651-68-2

Suc-Phe-Pro-Phe-pNA

Suc-Phe-Pro-Phe-pNA

Ref: 3D-FS110742