CAS 756525-94-7

Methoxypolyethylene glycol-succinimidyl propionate

Description:

Methoxypolyethylene glycol-succinimidyl propionate (MPEG-SP) is a bioconjugation reagent commonly used in biochemistry and pharmaceutical applications. It is characterized by its polyethylene glycol (PEG) backbone, which enhances solubility and biocompatibility, making it suitable for drug delivery systems and protein modification. The succinimidyl group in MPEG-SP allows for the formation of stable amide bonds with primary amines, facilitating the conjugation of proteins, peptides, or other biomolecules. This property is particularly valuable in the development of therapeutics and diagnostics, as it enables the targeted delivery of drugs or the creation of antibody-drug conjugates. MPEG-SP is typically a white to off-white solid and is soluble in a variety of organic solvents and water, depending on the molecular weight of the PEG component. Its use is prevalent in research and development settings, particularly in the fields of immunology and nanomedicine, where precise control over molecular interactions is crucial. Safety data should be reviewed before handling, as with all chemical reagents.

Formula: (C₂H₄O)nC₈H₁₁NO₅

InChI: InChI=1S/C10H15NO6/c1-15-6-7-16-5-4-10(14)17-11-8(12)2-3-9(11)13/h2-7H2,1H3

InChI key: InChIKey=IMSXKORGOVQCNT-UHFFFAOYSA-N

SMILES: O(C(CCOCCOC)=O)N1C(=O)CCC1=O

Synonyms:

• SP-mPEG
• Methoxypolyethylene glycol-succinimidyl propionate
• O-[2-(N-Succinimidyloxycarbonyl)ethyl]-O′-methylpolyethylene glycol
• Poly(oxy-1,2-ethanediyl), α-[3-[(2,5-dioxo-1-pyrrolidinyl)oxy]-3-oxopropyl]-ω-methoxy-
• mPEG-SPA

Methyl-PEG12-NHS Ester

CAS: 756525-94-7

Formula: C₃₀H₅₅NO₁₆

Color and Shape: White or Colorless to Almost white or Almost colorless powder to lump to clear liquid

Molecular weight: 685.76

Ref: 3B-M2188

mPEG12-NHS Ester

CAS: 756525-94-7

Formula: C₃₀H₅₅NO₁₆

Purity: 95%

Color and Shape: Liquid

Molecular weight: 685.7548

Ref: IN-DA00361F

m-PEG24-NHS ester

CAS: 756525-94-7

m-PEG24-NHS ester

Purity: 95%

Molecular weight: 1,214.39g/mol

Ref: 54-BIPG1631

Methyl-PEG12-NHS Ester

CAS: 756525-94-7

Methyl-PEG12-NHS Ester （m-PEG12-NHS ester） is often used as a PROTAC Linker for amine-containing molecules.

Formula: C₃₀H₅₅NO₁₆

Color and Shape: Solid

Molecular weight: 685.75

Ref: TM-T20901

NHS-m-dPEG® (MW = 685)

CAS: 756525-94-7

NHS-m-dPEG® (MW = 685) is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. NHS-m-dPEG® (MW = 685) is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.

Purity: Min. 95%

Molecular weight: 685.75 g/mol

Ref: 3D-DPG-5725

NHS-m-dPEG®(MW = 1214)

CAS: 756525-94-7

NHS-m-dPEG®(MW = 1214) is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. NHS-m-dPEG®(MW = 1214) is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.

Purity: Min. 95%

Molecular weight: 1,214.39 g/mol

Ref: 3D-DPG-5727