CAS 75659-07-3

(+)-Labetalol

Description:

(+)-Labetalol is a pharmaceutical compound primarily used as an antihypertensive agent. It belongs to the class of beta-blockers and has both alpha-1 adrenergic blocking and non-selective beta-adrenergic blocking properties, which contribute to its effectiveness in lowering blood pressure. The chemical formula of (+)-Labetalol is C19H24N2O3, and it features a chiral center, making it optically active. The compound is typically administered in its hydrochloride salt form, enhancing its solubility and bioavailability. (+)-Labetalol is known for its ability to reduce peripheral vascular resistance without significantly affecting heart rate, making it suitable for treating conditions such as hypertension and hypertensive emergencies. Its pharmacokinetics involve oral absorption, with a relatively long half-life, allowing for once or twice daily dosing. Side effects may include dizziness, fatigue, and gastrointestinal disturbances, which are common with beta-blockers. Overall, (+)-Labetalol is a valuable medication in managing cardiovascular conditions, particularly in patients with comorbidities.

Formula: C₁₉H₂₄N₂O₃

InChI: InChI=1S/C19H24N2O3/c1-13(7-8-14-5-3-2-4-6-14)21-12-18(23)15-9-10-17(22)16(11-15)19(20)24/h2-6,9-11,13,18,21-23H,7-8,12H2,1H3,(H2,20,24)/t13-,18+/m1/s1

InChI key: InChIKey=SGUAFYQXFOLMHL-ACJLOTCBSA-N

SMILES: [C@@H](CN[C@@H](CCC1=CC=CC=C1)C)(O)C2=CC(C(N)=O)=C(O)C=C2

Synonyms:

• (-)-5-((1R)-1-Hydroxy-2-((1R)-1-methyl-3-phenylpropylamino)ethyl)salicylamid
• (-)-5-((1R)-1-Hydroxy-2-((1R)-1-methyl-3-phenylpropylamino)ethyl)salicylamid [IUPAC]
• (R,R)-Labetalol
• 2-Hydroxy-5-((1R)-1-hydroxy-2-(((1R)-1-methyl-3-phenylpropyl)amino)ethyl)benzamide
• 2-hydroxy-5-[(1R)-1-hydroxy-2-{[(2R)-4-phenylbutan-2-yl]amino}ethyl]benzamide
• Benzamide, 2-hydroxy-5-((1R)-1-hydroxy-2-(((1R)-1-methyl-3-phenylpropyl)amino)ethyl)-
• Benzamide, 2-hydroxy-5-(1-hydroxy-2-((1-methyl-3-phenylpropyl)amino)ethyl)-, (R-(R*,R*))-
• Dilevalol [INN:BAN]
• Dilevalolum
• Dilevalolum [Latin]
• Dilevalon
• Labetalol
• Levadil
• Sch 19927
• Unicard

Dilevalol

CAS: 75659-07-3

Formula: C₁₉H₂₄N₂O₃

Molecular weight: 328.41

Ref: 7W-GP2197

(R,R)-Labetalol-d3 Hydrochloride

Controlled Product

CAS: 75659-07-3, 75659-08-4

Stability Very Hygroscopic
Applications Labelled (R,R)-Labetalol (L096500). (R,R)-Labetalol is a specific competitive antagonist at both α-and β-adrenergic receptor sites. (R,R)-Labetalol is used as an antihypertensive.
References Sybertz, E.J., et al.: J. Pharmacol. Exp. Ther., 218, 435 (1981), Clifton, J.E., et al.: J. Med. Chem., 25, 670 (1982), Goa, K.L., et al.: Drugs, 37, 583 (1989),

Formula: C₁₉H₂₂D₃ClN₂O₃

Color and Shape: Neat

Molecular weight: 367.88

Ref: TR-L096502

(R,R)-Labetalol

CAS: 75659-07-3

Formula: C₁₉H₂₄N₂O₃

Molecular weight: 328.41

Ref: ST-EA-CP-L7020

Dilevalol

CAS: 75659-07-3

Dilevalol, an RR-stereoisomer of labetalol, is a beta-blocker with partial beta 2-agonism and minimal alpha 1-blockade.

Formula: C₁₉H₂₄N₂O₃

Purity: 98%

Color and Shape: Solid

Molecular weight: 328.41

Ref: TM-T25333