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CAS 75715-89-8

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Leukotriene E4

Description:
Leukotriene E4 (LTE4) is a sulfur-containing lipid mediator that plays a significant role in inflammatory responses and is part of the leukotriene family, which are derived from arachidonic acid. It is produced by various immune cells, including mast cells and eosinophils, and is involved in processes such as bronchoconstriction, increased vascular permeability, and recruitment of immune cells to sites of inflammation. LTE4 is known for its potent effects in the pathophysiology of asthma and allergic reactions, contributing to airway hyperreactivity and inflammation. The compound is characterized by its structure, which includes a tetraene chain and a terminal carboxylic acid group, making it a polar molecule. Its biological activity is mediated through specific receptors, primarily the cysteinyl leukotriene receptors, which are implicated in various physiological and pathological processes. Due to its role in inflammatory diseases, LTE4 is a target for therapeutic interventions aimed at managing conditions like asthma and other allergic disorders.
Formula:C23H37NO5S
InChI:InChI=1S/C23H37NO5S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-21(30-18-19(24)23(28)29)20(25)15-14-17-22(26)27/h6-7,9-13,16,19-21,25H,2-5,8,14-15,17-18,24H2,1H3,(H,26,27)(H,28,29)/b7-6-,10-9-,12-11+,16-13+/t19-,20-,21+/m0/s1
InChI key:InChIKey=OTZRAYGBFWZKMX-FRFVZSDQSA-N
SMILES:[C@@H]([C@H](CCCC(O)=O)O)(SC[C@@H](C(O)=O)N)/C=C/C=C/C=C\C/C=C\CCCCC
Synonyms:
  • (5S,6R,7E,9E,11Z,14Z)-6-[(2-amino-2-carboxyethyl)sulfanyl]-5-hydroxyicosa-7,9,11,14-tetraenoic acid
  • (5S,6R,7E,9E,11Z,14Z)-6-[[(2R)-2-Amino-2-carboxyethyl]thio]-5-hydroxy-7,9,11,14-eicosatetraenoic acid
  • (5S,6R,7E,9E,11Z,14Z)-6-{[(2R)-2-amino-2-carboxyethyl]sulfanyl}-5-hydroxyicosa-7,9,11,14-tetraenoic acid
  • 7,9,11,14-Eicosatetraenoic acid, 6-((2-amino-2-carboxyethyl)thio)-5-hydroxy-, (5S-(5R*,6S*(S*),7E,9E,11Z,14Z))-
  • 7,9,11,14-Eicosatetraenoic acid, 6-[[(2R)-2-amino-2-carboxyethyl]thio]-5-hydroxy-, (5S,6R,7E,9E,11Z,14Z)-
  • LTE<sub>4</sub>
  • Leukotriene E
  • Leukotriene E<sub>4</sub>
  • Lte4
  • Leukotriene E4
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Found 3 products.