CAS 75899-57-9

Beclomethasone Hemisuccinate

Description:

Beclomethasone hemisuccinate is a synthetic corticosteroid with anti-inflammatory and immunosuppressive properties, primarily used in the treatment of various allergic and inflammatory conditions, including asthma and rhinitis. It is a derivative of beclomethasone, which is known for its potent glucocorticoid activity. The hemisuccinate form enhances its solubility and bioavailability, making it suitable for inhalation or intranasal delivery. This compound typically appears as a white to off-white powder and is characterized by its stability under normal storage conditions. Its mechanism of action involves the modulation of gene expression, leading to reduced production of pro-inflammatory cytokines and mediators. Beclomethasone hemisuccinate is generally well-tolerated, but like other corticosteroids, it may have side effects, particularly with long-term use, including potential impacts on the endocrine system and local irritation at the site of administration. Proper dosing and administration are crucial to minimize adverse effects while maximizing therapeutic benefits.

Formula: C₂₆H₃₃ClO₈

Synonyms:

• Beclomethasone Hemisuccinate
• 1, 4-PREGNADIEN-9α-CHLORO-16β-METHYL-11β, 17, 21-TRIOL-3, 20-DIONE 21-HEMISUCCINATE
• Pregna-1,4-diene-3,20-dione, 21-(3-carboxy-1-oxopropoxy)-9-chloro-11,17-dihydroxy-16-methyl-, (11β,16β)-

Beclomethasone Hemisuccinate

Controlled Product

CAS: 75899-57-9

Applications Beclomethasone Hemisuccinate is a derivative of Beclomethasone (B131000); a glucocorticoid used in chronic asthma and allergic rhinitis. Antiallergic, antiasthmatic (inhalant), and anti-inflammatory (topical).
References Malfitan, V.A., et al.: Clin. Ther., 4, 472 (1982); Rao, M., et al.: J. Asthma, 19, 21 (1982); Small, P., et al.: Ann. Allergy, 49, 127 (1982); Brogden, R.N., et al.: Drugs, 28, 99 (1984)

Formula: C₂₆H₃₃ClO₈

Color and Shape: Neat

Molecular weight: 508.99

Ref: TR-B131040

Beclomethasone Hemisuccinate-d4

Controlled Product

CAS: 75899-57-9

Formula: C₂₆D₄H₂₉ClO₈

Color and Shape: Neat

Molecular weight: 513.013

Ref: TR-B131042

Beclomethasone Hemisuccinate

CAS: 75899-57-9

Formula: C₂₆H₃₃ClO₈

Molecular weight: 508.99

Ref: ST-EA-CP-B88010