CAS 76093-35-1

(+)-Nicardipine

Description:

(+)-Nicardipine is a calcium channel blocker primarily used in the treatment of hypertension and angina pectoris. It belongs to the dihydropyridine class of compounds and is characterized by its ability to selectively inhibit L-type calcium channels, leading to vasodilation and reduced cardiac workload. The molecular formula of (+)-Nicardipine is C20H26N2O6, and it features a chiral center, which contributes to its pharmacological activity. This compound is typically administered in its hydrochloride salt form and is known for its rapid onset of action and relatively short half-life. In addition to its antihypertensive effects, (+)-Nicardipine has been studied for its potential neuroprotective properties, particularly in conditions such as stroke. Its solubility profile indicates that it is more soluble in organic solvents than in water, which can influence its formulation and delivery methods. As with many medications, (+)-Nicardipine may have side effects, including headache, flushing, and peripheral edema, necessitating careful monitoring during treatment.

Formula: C₂₆H₂₉N₃O₆

InChI: InChI=1S/C26H29N3O6/c1-17-22(25(30)34-4)24(20-11-8-12-21(15-20)29(32)33)23(18(2)27-17)26(31)35-14-13-28(3)16-19-9-6-5-7-10-19/h5-12,15,24,27H,13-14,16H2,1-4H3/t24-/m1/s1

InChI key: InChIKey=ZBBHBTPTTSWHBA-XMMPIXPASA-N

SMILES: C(OCCN(CC1=CC=CC=C1)C)(=O)C=2[C@@H](C(C(OC)=O)=C(C)NC2C)C3=CC(N(=O)=O)=CC=C3

Synonyms:

• 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 3-methyl 5-[2-[methyl(phenylmethyl)amino]ethyl] ester, (4R)-
• (R)-Nicardipine
• 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, methyl 2-[methyl(phenylmethyl)amino]ethyl ester, (R)-
• 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, methyl 2-[methyl(phenylmethyl)amino]ethyl ester, (4R)-
• (+)-Nicardipine
• (R)-YC-93 free base
• Nicardipine Impurity 13 ((R)-(+)-Nicardipine)

(R)-Nicardipine

CAS: 76093-35-1

Formula: C₂₆H₂₉N₃O₆

Molecular weight: 479.53

Ref: 4Z-N-4814

(R)-Nicardipine

CAS: 76093-35-1

(R)-Nicardipine is the less active R enantiomer of Nicardipine. Nicardipine is a blocker of calcium channel(IC50 of 1 μM for blocking cardiac calcium channels).

Formula: C₂₆H₂₉N₃O₆

Color and Shape: Solid

Molecular weight: 479.53

Ref: TM-T12633

(R)-Nicardipine

CAS: 76093-35-1

Formula: C₂₆H₂₉N₃O₆

Molecular weight: 479.53

Ref: ST-EA-CP-N7044