CAS 760937-92-6

Teneligliptin

Description:

Teneligliptin is an oral antihyperglycemic agent belonging to the class of dipeptidyl peptidase-4 (DPP-4) inhibitors, primarily used in the management of type 2 diabetes mellitus. Its mechanism of action involves the inhibition of the DPP-4 enzyme, which leads to increased levels of incretin hormones, thereby enhancing insulin secretion and reducing glucagon release in a glucose-dependent manner. This results in improved glycemic control. Teneligliptin is characterized by its chemical formula, which includes a specific arrangement of carbon, hydrogen, nitrogen, and oxygen atoms, contributing to its pharmacological properties. It is typically administered orally and is known for its favorable safety profile and low risk of hypoglycemia when used alone. Additionally, Teneligliptin has been noted for its potential benefits in weight management and cardiovascular health in diabetic patients. As with any medication, it is essential to consider potential side effects and contraindications, and it should be used under medical supervision.

Formula: C₂₂H₃₀N₆OS

InChI: InChI=1S/C22H30N6OS/c1-17-13-21(28(24-17)18-5-3-2-4-6-18)26-9-7-25(8-10-26)19-14-20(23-15-19)22(29)27-11-12-30-16-27/h2-6,13,19-20,23H,7-12,14-16H2,1H3/t19-,20-/m0/s1

InChI key: InChIKey=WGRQANOPCQRCME-PMACEKPBSA-N

SMILES: CC=1C=C(N(N1)C2=CC=CC=C2)N3CCN(CC3)[C@H]4C[C@@H](C(=O)N5CCSC5)NC4

Synonyms:

• 3-[[(2S,4S)-4-[4-(3-Methyl-1-phenyl-1H-pyrazol-5-yl)-1-piperazinyl]-2-pyrrolidinyl]carbonyl]thiazolidine
• Methanone, [(2S,4S)-4-[4-(3-methyl-1-phenyl-1H-pyrazol-5-yl)-1-piperazinyl]-2-pyrrolidinyl]-3-thiazolidinyl-
• Tenelia
• Thiazolidine, 3-[[(2S,4S)-4-[4-(3-methyl-1-phenyl-1H-pyrazol-5-yl)-1-piperazinyl]-2-pyrrolidinyl]carbonyl]-
• [(2S,4S)-4-[4-(3-Methyl-1-phenyl-1H-pyrazol-5-yl)-1-piperazinyl]-2-pyrrolidinyl]-3-thiazolidinylmethanone
• Teneligliptin

Teneligliptin

CAS: 760937-92-6

Formula: C₂₂H₃₀N₆OS

Purity: 98%

Color and Shape: Solid

Molecular weight: 426.5782

Ref: IN-DA00G3Q1

Teneligliptin

CAS: 760937-92-6

Teneligliptin

Purity: ≥98%

Molecular weight: 426.58g/mol

Ref: 54-BUP10637

Teneligliptin-d4

CAS: 760937-92-6

Formula: C₂₂H₂₆D₄N₆OS

Color and Shape: White To Off-White Solid

Molecular weight: 430.61

Ref: 4Z-T-145002

Teneligliptin

CAS: 760937-92-6

Teneligliptin (MP-513), potent DPP-4 inhibitor, IC50 ~1 nM, blocks DPP-4 in human/rat plasma and recombinant forms.

Formula: C₂₂H₃₀N₆OS

Purity: 99.73%

Color and Shape: Solid

Molecular weight: 426.58

Ref: TM-T37522

Teneligliptin

Controlled Product

CAS: 760937-92-6

Formula: C₂₂H₃₀N₆OS

Color and Shape: Off-White

Molecular weight: 426.58

Ref: TR-T018295

Teneligliptin-d4

Controlled Product

CAS: 760937-92-6

Formula: C₂₂D₄H₂₆N₆OS

Color and Shape: Neat

Molecular weight: 430.603

Ref: TR-T018303

Teneligliptin

CAS: 760937-92-6

Teneligliptin is a selective inhibitor of the P-glycoprotein (P-gp) transporter and is used for the treatment of type 2 diabetes. Teneligliptin has been shown to reduce postprandial blood glucose levels by inhibiting DPP-IV, which is an enzyme that degrades glucagon-like peptide 1 (GLP-1). It also inhibits the activity of dpp-4, which is an enzyme that inactivates GLP-1. The combination therapy group had significantly lower HbA1c levels than the control analysis group in a study of teneligliptin and metformin. Teneligliptin has also been shown to have a long half life and low risk of drug interactions in human pharmacokinetic studies.

Formula: C₂₂H₃₀N₆OS

Purity: Min. 95%

Molecular weight: 426.58 g/mol

Ref: 3D-FT150538