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CAS 76095-16-4

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Enalapril maleate

Description:
Enalapril maleate is a pharmaceutical compound primarily used as an antihypertensive agent in the treatment of high blood pressure and heart failure. It is an ester derivative of enalapril, which is an angiotensin-converting enzyme (ACE) inhibitor. The maleate salt form enhances the solubility and stability of the drug. Enalapril maleate is typically a white to off-white crystalline powder, with a molecular formula that reflects its complex structure, including both the enalapril and maleate components. It is soluble in water and methanol but has limited solubility in organic solvents. The compound works by inhibiting the ACE enzyme, leading to decreased production of angiotensin II, which results in vasodilation and reduced blood pressure. Common side effects may include dizziness, fatigue, and cough, while serious adverse effects can involve renal impairment and hyperkalemia. Enalapril maleate is usually administered orally and is often prescribed in combination with other antihypertensive medications for enhanced efficacy.
Formula:C24H32N2O9
InChI:InChI=1/C20H28N2O5.C4H4O4/c1-3-27-20(26)16(12-11-15-8-5-4-6-9-15)21-14(2)18(23)22-13-7-10-17(22)19(24)25;5-3(6)1-2-4(7)8/h4-6,8-9,14,16-17,21H,3,7,10-13H2,1-2H3,(H,24,25);1-2H,(H,5,6)(H,7,8)/b;2-1-/t14-,16?,17-;/m0./s1
SMILES:C([C@@H](N[C@@H](CCC1=CC=CC=C1)C(OCC)=O)C)(=O)N2[C@H](C(O)=O)CCC2.C(=C\C(O)=O)\C(O)=O
Synonyms:
  • (2S)-1-[(2S)-2-[(1-ethoxycarbonyl-3-phenyl-propyl)amino]propanoyl]pyrrolidine-2-carboxylic acid
  • (2S)-1-[2-[(1-ethoxycarbonyl-3-phenyl-propyl)amino]propanoyl]pyrrolidine-2-carboxylic acid
  • (S)-1-(N-(1-(Ethoxycarbonyl)-3-Phenylpropyl)-L-Alanyl)-L-Proline (Z)-2-Butenedioate Salt
  • <span class="text-smallcaps">L</smallcap>-Proline, 1-[N-[1-(ethoxycarbonyl)-3-phenylpropyl]-<smallcap>L</span>-alanyl]-, (S)-, (Z)-2-butenedioate (1:1)
  • <span class="text-smallcaps">L</smallcap>-Proline, N-[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]-<smallcap>L</span>-alanyl-, (2Z)-2-butenedioate (1:1)
  • Acapril
  • Acetensil
  • Alphrin
  • Amprace
  • Analept
  • See more synonyms
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