CAS 760981-83-7

Solithromycin

Description:

Solithromycin is a synthetic antibiotic belonging to the macrolide class, specifically designed to combat bacterial infections. It is characterized by its broad-spectrum activity against various Gram-positive and Gram-negative bacteria, including strains resistant to other antibiotics. Solithromycin operates by inhibiting bacterial protein synthesis through binding to the 50S ribosomal subunit, effectively disrupting the translation process. This compound is notable for its improved pharmacokinetic properties, including enhanced oral bioavailability and a longer half-life, which allows for less frequent dosing compared to traditional macrolides. Solithromycin has been investigated primarily for the treatment of respiratory tract infections, such as community-acquired pneumonia. Additionally, it exhibits anti-inflammatory properties, which may contribute to its therapeutic effects. The substance is generally well-tolerated, with a side effect profile similar to other macrolides, though it may cause gastrointestinal disturbances in some patients. Overall, Solithromycin represents a significant advancement in antibiotic therapy, particularly in the face of rising antibiotic resistance.

Formula: C₄₃H₆₅FN₆O₁₀

InChI: InChI=1S/C43H65FN6O10/c1-12-32-43(8)35(50(40(55)60-43)19-14-13-18-49-23-30(46-47-49)28-16-15-17-29(45)21-28)26(4)33(51)24(2)22-41(6,56-11)37(27(5)36(53)42(7,44)39(54)58-32)59-38-34(52)31(48(9)10)20-25(3)57-38/h15-17,21,23-27,31-32,34-35,37-38,52H,12-14,18-20,22,45H2,1-11H3/t24-,25-,26+,27+,31+,32-,34-,35-,37-,38+,41-,42+,43-/m1/s1

InChI key: InChIKey=IXXFZUPTQVDPPK-ZAWHAJPISA-N

SMILES: C[C@@]12[C@](N(CCCCN3C=C(N=N3)C4=CC(N)=CC=C4)C(=O)O1)([C@@H](C)C(=O)[C@H](C)C[C@](OC)(C)[C@H](O[C@H]5[C@H](O)[C@@H](N(C)C)C[C@@H](C)O5)[C@@H](C)C(=O)[C@](C)(F)C(=O)O[C@@H]2CC)[H]

Synonyms:

• OP 1068
• CEM 101
• Solithromycin
• (3aS,4R,7S,9R,10R,11R,13R,15R,15aR)-1-[4-[4-(3-Aminophenyl)-1H-1,2,3-triazol-1-yl]butyl]-4-ethyl-7-fluorooctahydro-11-methoxy-3a,7,9,11,13,15-hexamethyl-10-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosyl]oxy]-2H-oxacyclotetradecino[4,3-d]oxazole-2,6,8,14(1H,7H,9H)-tetrone
• 2H-Oxacyclotetradecino[4,3-d]oxazole-2,6,8,14(1H,7H,9H)-tetrone, 1-[4-[4-(3-aminophenyl)-1H-1,2,3-triazol-1-yl]butyl]-4-ethyl-7-fluorooctahydro-11-methoxy-3a,7,9,11,13,15-hexamethyl-10-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosyl]oxy]-, (3aS,4R,7S,9R,10R,11R,13R,15R,15aR)-

Solithromycin

CAS: 760981-83-7

Solithromycin

Purity: ≥98%

Molecular weight: 845.01g/mol

Ref: 54-BUP09818

Solithromycin

CAS: 760981-83-7

Solithromycin, an oral antimicrobial, blocks protein synthesis in various bacteria with IC50s: 7.5-125 ng/mL.

Formula: C₄₃H₆₅FN₆O₁₀

Purity: 98.58% - 99.42%

Color and Shape: Solid

Molecular weight: 845.01

Ref: TM-T2331

SOLITHROMYCIN

CAS: 760981-83-7

Molecular weight: 845.0230103

Ref: 10-F866625

Solithromycin

CAS: 760981-83-7

Solithromycin is a novel macrolide antibiotic, which is derived from the compound ketolide. It functions by binding to the bacterial 50S ribosomal subunit, effectively inhibiting protein synthesis. This mechanism of action enables Solithromycin to exert its effects against a wide range of bacterial pathogens, including strains resistant to traditional macrolides. The unique binding capability to multiple sites on the ribosome enhances its potency and reduces the likelihood of resistance development.

Formula: C₄₃H₆₅FN₆O₁₀

Purity: Min. 95%

Molecular weight: 845.01 g/mol

Ref: 3D-KFB98183

SOLITHROMYCIN

CAS: 760981-83-7

Formula: C₄₃H₆₅FN₆O₁₀

Purity: 98%

Color and Shape: Solid

Molecular weight: 845.0088

Ref: IN-DA00G3RL