CAS 761373-05-1

(2S,4R)-Sacubitril (4-(((2R,4S)-1-([1,1'-biphenyl]-4-yl)-5-ethoxy-4-methyl-5-oxopentan-2-yl)amino)-4-oxobutanoic acid)

CAS: 761373-05-1

Aromatic cyclic amides (including cyclic carbamates) and their derivatives; salts thereof

Formula: C₂₄H₂₉NO₅

Color and Shape: Off-White Solid

Molecular weight: 411.20457

Ref: 45-1A11960

(2R,4S)-5-(Biphenyl-4-yl)-4-[(3-carboxypropionyl)amino]-2-methylpentanoic acid ethyl ester

CAS: 761373-05-1

Formula: C₂₄H₂₉NO₅

Purity: 98%

Color and Shape: Solid

Molecular weight: 411.4908

Ref: IN-DA00G3S8

Sacubitril Enantiomer

CAS: 761373-05-1

Formula: C₂₄H₂₉NO₅

Color and Shape: White To Off-White Semi-Solid

Molecular weight: 411.50

Ref: 4Z-S-072004

(2S,4R)-Sacubitril

Controlled Product

CAS: 761373-05-1

Stability Temperature Sensitive
Applications (2S,4R)-Sacubitril is the enantiomer and an impurity of Sacubitril (S080895) which is an antihypertensive drug used in combination with valsartan.
References McMurray, J., et al.: N. Eng. J. Med., 371 (2014);

Formula: C₂₄H₂₉NO₅

Color and Shape: Colourless To Off-White

Molecular weight: 411.49

Ref: TR-S080905

(2R,4S)-Sacubitril

CAS: 761373-05-1

Formula: C₂₄H₂₉NO₅

Molecular weight: 411.50

Ref: ST-EA-CP-S18023

2R,4S-Sacubitril

CAS: 761373-05-1

2R,4S-Sacubitril (Sacubitril Enantiomer) is the impurity of Sacubitril which is a neprilysin inhibitor.

Formula: C₂₄H₂₈NO₅₁Ca

Purity: 98%

Color and Shape: Solid

Molecular weight: 430.49

Ref: TM-T19112