ALK inhibitor 1, also known by its chemical name and CAS number 761436-81-1, is a small molecule that acts as a selective inhibitor of the anaplastic lymphoma kinase (ALK) enzyme. This compound is primarily studied for its potential therapeutic applications in treating cancers characterized by ALK gene rearrangements, such as non-small cell lung cancer (NSCLC). The mechanism of action involves binding to the ATP-binding site of the ALK protein, thereby preventing its phosphorylation and subsequent activation, which is crucial for tumor cell proliferation and survival. ALK inhibitor 1 exhibits high specificity for ALK over other kinases, minimizing off-target effects. In preclinical studies, it has demonstrated efficacy in inhibiting tumor growth and inducing apoptosis in ALK-positive cancer cell lines. Additionally, its pharmacokinetic properties, including absorption, distribution, metabolism, and excretion, are critical for determining its suitability for clinical use. Ongoing research aims to further elucidate its safety profile and potential resistance mechanisms in cancer therapy.

ALK inhibitor 1

761436-81-1: ALK inhibitor 1, also known by its chemical name and CAS number 761436-81-1, is a small molecule that acts as a selective inhibitor of the anaplastic lymphoma kinase (ALK) enzyme. This compound is primarily studied for its potential therapeutic applications in treating cancers characterized by ALK gene rearrangements, such as non-small cell lung cancer (NSCLC). The mechanism of action involves binding to the ATP-binding site of the ALK protein, thereby preventing its phosphorylation and subsequent activation, which is crucial for tumor cell proliferation and survival. ALK inhibitor 1 exhibits high specificity for ALK over other kinases, minimizing off-target effects. In preclinical studies, it has demonstrated efficacy in inhibiting tumor growth and inducing apoptosis in ALK-positive cancer cell lines. Additionally, its pharmacokinetic properties, including absorption, distribution, metabolism, and excretion, are critical for determining its suitability for clinical use. Ongoing research aims to further elucidate its safety profile and potential resistance mechanisms in cancer therapy.

<p>ALK inhibitor 1 is a selective ALK kinase inhibitor.</p>

<p>ALK Inhibitor 1 is a protein kinase inhibitor that inhibits the activity of tyrosine kinases. Tyrosine kinases are enzymes that regulate the activities of other proteins and play an important role in the development of cancer cells. ALK Inhibitor 1 can be used for the treatment of cancer cells. It has been shown to regulate a number of cancer-related genes and normalize them, which may reduce tumor growth.</p>

CAS 761436-81-1

ALK inhibitor 1

ALK inhibitor 1

Ref: TM-T10285

ALK inhibitor 1

Ref: 54-BUP02395

ALK Inhibitor 1

Ref: 3D-LFB43681