CAS 761439-42-3

5-Chloro-N2-[2-methoxy-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]-N4-[2-[(1-methylethyl)sulfonyl]phenyl]-2,4-pyrimidinediamine

Description:

5-Chloro-N2-[2-methoxy-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]-N4-[2-[(1-methylethyl)sulfonyl]phenyl]-2,4-pyrimidinediamine, with CAS number 761439-42-3, is a synthetic organic compound characterized by its complex structure, which includes multiple functional groups such as piperazine and piperidine moieties, a pyrimidinediamine core, and a sulfonyl group. This compound is typically classified as a small molecule and may exhibit properties relevant to medicinal chemistry, particularly in the context of drug development. Its structural features suggest potential interactions with biological targets, making it of interest in pharmacological research. The presence of chlorine and methoxy groups may influence its solubility, stability, and biological activity. As with many compounds in this category, its efficacy and safety profile would need to be evaluated through rigorous testing in preclinical and clinical studies. Overall, this compound exemplifies the complexity often found in drug-like molecules, which are designed to interact with specific biological pathways.

Formula: C₃₀H₄₀ClN₇O₃S

InChI: InChI=1S/C30H40ClN7O3S/c1-21(2)42(39,40)28-8-6-5-7-26(28)33-29-24(31)20-32-30(35-29)34-25-10-9-23(19-27(25)41-4)37-13-11-22(12-14-37)38-17-15-36(3)16-18-38/h5-10,19-22H,11-18H2,1-4H3,(H2,32,33,34,35)

InChI key: InChIKey=QQWUGDVOUVUTOY-UHFFFAOYSA-N

SMILES: N(C1=C(S(C(C)C)(=O)=O)C=CC=C1)C2=NC(NC3=C(OC)C=C(C=C3)N4CCC(CC4)N5CCN(C)CC5)=NC=C2Cl

Synonyms:

• 2,4-Pyrimidinediamine, 5-chloro-N²-[2-methoxy-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]-N⁴-[2-[(1-methylethyl)sulfonyl]phenyl]-
• 5-Chloro-N²-[2-methoxy-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]-N⁴-[2-[(1-methylethyl)sulfonyl]phenyl]-2,4-pyrimidinediamine
• Ae 684
• Nvp-Tae 684
• Nvp-Tae684-Tae 684
• Nvt Tae-684
• Tae 684
• Tae684(Nvp-Tae684)
• 5-Chloro-N2-[2-methoxy-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]-N4-[2-[(1-methylethyl)sulfonyl]phenyl]-2,4-pyrimidinediamine
• 2,4-Pyrimidinediamine, 5-chloro-N2-[2-methoxy-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]-N4-[2-[(1-methylethyl)sulfonyl]phenyl]-

TAE684 (NVP-TAE684)

CAS: 761439-42-3

Formula: C₃₀H₄₀ClN₇O₃S

Purity: 98%

Color and Shape: Solid

Molecular weight: 614.2017

Ref: IN-DA00G3PF

NVP-TAE 684

CAS: 761439-42-3

NVP-TAE 684

Purity: ≥98%

Molecular weight: 614.2g/mol

Ref: 54-BUP05721

TAE684

CAS: 761439-42-3

Ref: 7W-GW1397

NVP-TAE 684

CAS: 761439-42-3

NVP-TAE 684 (TAE684) is a excellently effective and specific ALK inhibitor(IC50=3 nM).

Formula: C₃₀H₄₀ClN₇O₃S

Purity: 98% - 99.82%

Color and Shape: Solid

Molecular weight: 614.2

Ref: TM-T2251

NVP-TAE684

CAS: 761439-42-3

Inhibitor of NPM-ALK kinase

Formula: C₃₀H₄₀ClN₇O₃S

Purity: Min. 95%

Molecular weight: 614.2 g/mol

Ref: 3D-FN65109

TAE 684

Controlled Product

CAS: 761439-42-3

Applications TAE 684 is a potent, selective, and efficacious inhibitor of NPM-ALK, a fusion protein that is a key regulator of oncogenic events that drives the survival and proliferation of anaplastic large-cell lymphomas. Potent ALK inhibitor
References Schoenherr, C., et al.: Oncogene., 31, 5193 (2012); Tanizaki, J., et al.: Clin. Cancer. Res., 18, 6219 (2012); Heuckmann, J.M., et al.: Clin. Cancer. Res., 18, 4682 (2012);

Formula: C₃₀H₄₀ClN₇O₃S

Color and Shape: Neat

Molecular weight: 614.20

Ref: TR-T004600