CAS 76144-81-5

Meldonium

Description:

Meldonium, also known as Mildronate, is a synthetic compound primarily used as a medication to treat ischemic heart conditions and enhance physical performance. It was developed in the 1970s in Latvia and is classified as a metabolic modulator. The chemical formula for meldonium is C5H13N1O2, and it features a unique structure that includes a 1,2,4-triazole ring. Meldonium works by inhibiting the enzyme carnitine acyltransferase, which plays a role in fatty acid metabolism, thereby promoting glucose utilization over fatty acids for energy production. This shift can enhance endurance and reduce fatigue during physical exertion. The substance has gained attention in sports due to its performance-enhancing effects, leading to its inclusion on the World Anti-Doping Agency's list of prohibited substances. While it is generally well-tolerated, potential side effects may include headaches, dizziness, and gastrointestinal disturbances. Its use should be monitored, especially in individuals with pre-existing health conditions.

Formula: C₆H₁₄N₂O₂

InChI: InChI=1/C8H17NO5/c10-2-1-9-3-6(12)8(14)7(13)5(9)4-11/h5-8,10-14H,1-4H2/t5?,6-,7-,8?/m1/s1

InChI key: InChIKey=PVBQYTCFVWZSJK-UHFFFAOYSA-N

SMILES: N(CCC([O-])=O)[N+](C)(C)C

Synonyms:

• 1,1,1-Trimethyl-2-(2-carboxyethyl)hydrazine zwitterion
• 2-(2-Carboxyethyl)-1,1,1-Trimethylhydrazinium Hydroxide Inner Salt
• 2-(2-Carboxyethyl)-1,1,1-trimethyl Hydrazinium Inner Salt
• 3-(2,2,2-Trimethylhydrazine)Propionate
• 3-(2,2,2-Trimethylhydrazinium)propionate
• 3-(Trimethylammonioamino)Propanoate
• 3-[(Trimethylazaniumyl)amino]propanoate
• Hydrazinium, 2-(2-carboxyethyl)-1,1,1-trimethyl-, inner salt
• Hydrinol
• Idrinol
• Meldomiun
• Meldonium
• Met 88
• Met88
• Mildonate
• Quateri
• Quaterin
• Vasonat
• Mildronate
• N-Trimethyl-hydrazine-3-propionate
• 1,1,1-Trimethylhydrazinium 2-propionate
• 3-[(Trimethylaminio)amino]propionic acidanion
• 2-(2-Carboxylatoethyl)-1,1,1-trimethylhydrazinium

1,1,1-Trimethyl-2-(2-carboxyethyl)hydrazine zwitterion

CAS: 76144-81-5

Formula: C₆H₁₄N₂O₂

Purity: 98%

Color and Shape: Solid

Molecular weight: 146.1876

Ref: IN-DA00IKH3

Mildronate-d3

CAS: 76144-81-5

Formula: C₆H₁₁N₂O₂D₃

Color and Shape: White To Off-White Solid

Molecular weight: 149.21

Ref: 4Z-M-511

Mildronate-d3 HCl

CAS: 76144-81-5

Formula: C₆H₁₁D₃N₂O₂·HCl

Color and Shape: White To Off-White Solid

Molecular weight: 149.21 36.46

Ref: 4Z-M-515

Mildronate

CAS: 76144-81-5

Formula: C₆H₁₄N₂O₂

Purity: ≥ 98.0%

Color and Shape: White to off-white crystalline powder

Molecular weight: 146.19

Ref: 7W-GP7996

Mildronate

CAS: 76144-81-5

Formula: C₆H₁₄N₂O₂

Molecular weight: 146.19

Ref: 4Z-M-512

Mildronate

CAS: 76144-81-5

Mildronate (Meldonium) is an inhibitor of biosynthesis of L-carnitine by gamma-butyrobetaine (GBB) hydroxylase and as a competitive inhibitor of renal carnitine

Formula: C₆H₁₄N₂O₂

Purity: 99.94%

Color and Shape: White Crystalline Powder

Molecular weight: 146.19

Ref: TM-T3268

Mildronate-d3

Controlled Product

CAS: 76144-81-5

Stability Very Hygroscopic
Applications Mildronate-d3 is the labeled analogue of Mildronate (M344450), a novel pharmaceutical composition based on a reverse transcriptase inhibitor and meldonium. May contain a significant amount of water.

Formula: C₆H₁₁D₃N₂O₂

Color and Shape: White To Off-White

Molecular weight: 149.21

Ref: TR-M344452

Meldonium

Controlled Product

CAS: 76144-81-5

Mildronate is a drug with a matrix effect that has been shown to be effective in experimental models. Mildronate is used to treat cardiac arrhythmias and myocardial infarcts, as well as other cardiovascular diseases. Mildronate also has pharmacological effects on the brain, including protecting against brain toxicity and improving cognitive functions. The drug has been shown to have an effect on the blood pressure, energy metabolism, and pharmacological treatment of diseases. Mildronate was discovered during an analytical study of erythrocyte membranes and its effects were studied in detail. It was found that mildronate improved the membrane's stability and increased its resistance to hemolysis. This discovery led scientists to investigate mildronate as a possible treatment for heart conditions involving blood clots or low blood flow.

Formula: C₆H₁₄N₂O₂

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 146.19 g/mol

Ref: 3D-FM26003

Meldonium

Controlled Product

CAS: 76144-81-5

Meldonium is a cardiovascular drug, which is a synthetic compound originating from Latvia. It functions by modulating carnitine metabolism, leading to decreased fatty acid oxidation and augmented glucose oxidation. This shift in energy substrate helps to improve energy efficiency, particularly under conditions of ischemia, which can prevent ischemic damage by balancing oxygen supply and demand.

Formula: C₆H₁₄N₂O₂

Purity: Min. 95 Area-%

Molecular weight: 146.19 g/mol

Ref: 3D-Q-201406