CAS 76168-82-6
:Ramoplanin
Description:
Ramoplanin is a glycopeptide antibiotic that is primarily derived from the fermentation of the bacterium *Amycolatopsis orientalis*. It exhibits potent antibacterial activity, particularly against Gram-positive bacteria, including strains resistant to other antibiotics. The mechanism of action of Ramoplanin involves the inhibition of cell wall synthesis by binding to lipid II, a crucial precursor in peptidoglycan biosynthesis. This binding disrupts the formation of the bacterial cell wall, leading to cell lysis and death. Ramoplanin is notable for its stability in the presence of various enzymes, which enhances its therapeutic potential. It has been investigated for use in treating infections caused by multi-drug resistant organisms, particularly in clinical settings where conventional antibiotics may fail. Additionally, Ramoplanin has a relatively low toxicity profile, making it a candidate for further development in antibiotic therapy. Its unique structure and mechanism of action contribute to its significance in the ongoing battle against antibiotic resistance.
Formula:C106H170ClN21O30
InChI:InChI=1/C106H170ClN21O30/c1-8-9-10-11-15-22-80(140)114-75(50-78(110)138)96(147)118-76(51-79(111)139)97(148)124-86(60-25-36-66(133)37-26-60)102(153)117-72(21-17-46-109)92(143)120-83(56(6)130)100(151)126-89(63-31-42-69(136)43-32-63)105(156)127-88(62-29-40-68(135)41-30-62)104(155)121-82(55(5)129)99(150)119-74(48-58-18-13-12-14-19-58)95(146)116-71(20-16-45-108)93(144)123-87(61-27-38-67(134)39-28-61)103(154)122-84(57(7)131)101(152)125-85(59-23-34-65(132)35-24-59)98(149)112-52-81(141)115-73(47-53(2)3)94(145)113-54(4)91(142)128-90(106(157)158)64-33-44-77(137)70(107)49-64/h10-15,18-19,22,53-57,59-77,82-90,129-137H,8-9,16-17,20-21,23-52,108-109H2,1-7H3,(H2,110,138)(H2,111,139)(H,112,149)(H,113,145)(H,114,140)(H,115,141)(H,116,146)(H,117,153)(H,118,147)(H,119,150)(H,120,143)(H,121,155)(H,122,154)(H,123,144)(H,124,148)(H,125,152)(H,126,151)(H,127,156)(H,128,142)(H,157,158)/b11-10-,22-15-/t54-,55+,56+,57+,59?,60?,61?,62?,63?,64?,65?,66?,67?,68?,69?,70?,71-,72-,73+,74+,75+,76?,77?,82+,83-,84+,85?,86-,87?,88-,89-,90?/m1/s1
Synonyms:- A 16686
- A 16686A
- Antibiotic A 16686
- Antibiotic A 16686, 2-(((3alpha,5beta)-3-hydroxy-7,24-dioxocholan-24-yl)amino)-, (SP-4-2)-
- Glycolipodepsi peptide antibiotic produced by actinoplanes species ATCC33076
- Glycolipodepsi peptide antibiotic produced by actinoplanes species ATCC33076. Ramoplanin is a complex antibiotic consisting of a main component designated as ramoplanin A2 and a small amount of related substances, ramoplanin A1, A'1, A'2, A3, and A'3
- Mdl 62,198
- Ramoplanin [USAN:INN]
- Ramoplanin
- RaMoplanin(A 16686,A 16686A)
- Ramoplaninr
- See more synonyms
Sort by
Purity (%)
0
100
|
0
|
50
|
90
|
95
|
100
Found 4 products.
Ramoplanin
CAS:Ramoplanin is an antibiotic derived from Actinoplanes spp, a local glycopeptide antimicrobial agent that inhibits Gram-positive bacteria.Purity:98%Color and Shape:SolidRamoplanin
CAS:Controlled Product<p>Applications Ramoplanin is a potent cyclic lipoglycodepsipeptide antibiotic that exhibits wide spectrum of antibiotic properties against gram-positive and gram-negative bacteria.<br>References Therien, A.G., et al.: Antimicrob. Agent. Chemo., 56, 4662 (2012); Salzberg, L.I., et al.: J. Bacteriol., 193, 5793 (2011); D’Elia, M.A., et al.: Chem. Biol., 16, 548 (2009);<br></p>Formula:C119H156ClN21O40Color and Shape:NeatMolecular weight:2554.07Ramoplanin Acetate >85%
CAS:Controlled Product<p>Applications Ramoplanin Acetate is a derivative of Ramoplanin(R113030) which is a potent cyclic lipoglycodepsipeptide antibiotic that exhibits wide spectrum of antibiotic properties against gram-positive and gram-negative bacteria.<br>References Therien, A.G., et al.: Antimicrob. Agent. Chemo., 56, 4662 (2012); Salzberg, L.I., et al.: J. Bacteriol., 193, 5793 (2011); D’Elia, M.A., et al.: Chem. Biol., 16, 548 (2009);<br></p>Formula:C119H154ClN21O40•x(C2H4O2)Purity:>85%Color and Shape:NeatMolecular weight:2554.07 + x(60.05)
