CAS 763111-49-5

4-[3-(1,4-diazepan-1-ylcarbonyl)-4-fluorobenzyl]phthalazin-1(2H)-one

Description:

4-[3-(1,4-diazepan-1-ylcarbonyl)-4-fluorobenzyl]phthalazin-1(2H)-one, identified by its CAS number 763111-49-5, is a synthetic organic compound characterized by its complex structure, which includes a phthalazinone core and a diazepane moiety. This compound features a fluorobenzyl group, which contributes to its potential biological activity and lipophilicity. The presence of the diazepane ring suggests possible interactions with biological targets, making it of interest in medicinal chemistry. The compound may exhibit properties such as solubility in organic solvents, and its reactivity can be influenced by the functional groups present. Its specific applications and biological activities would depend on further studies, including pharmacological evaluations. Overall, this compound represents a class of heterocyclic compounds that may have implications in drug development and therapeutic applications.

Formula: C₂₁H₂₁FN₄O₂

InChI: InChI=1/C21H21FN4O2/c22-18-7-6-14(12-17(18)21(28)26-10-3-8-23-9-11-26)13-19-15-4-1-2-5-16(15)20(27)25-24-19/h1-2,4-7,12,23H,3,8-11,13H2,(H,25,27)

SMILES: c1ccc2c(c1)c(Cc1ccc(c(c1)C(=O)N1CCCNCC1)F)nnc2O

KU-0058948

Controlled Product

CAS: 763111-49-5

Applications KU-0058948 is a poly (ADP-ribose) polymerase (PARP) inhibitor. Studies show that KU-0058948 is a potent agonist that activates transfected extracellular signal-regulated kinase 8 (ERK8) in cells. KU-0058948 induces cell cycle arrest and apoptosis of primary myeloid leukemic cells and myeloid leukemic cell lines in vitro
References Klevernic, I.V. et al.: FEBS Lett., 583, 680 (2009); Gaymes, T.J. et al.: Haematologica, 94, 638 (2009);

Formula: C₂₁H₂₁FN₄O₂

Color and Shape: Neat

Molecular weight: 380.42

Ref: TR-K660400

KU-0058948

CAS: 763111-49-5

KU-0058948: PARP inhibitor, triggers cell cycle arrest and apoptosis in myeloid leukemia cells in vitro.

Formula: C₂₁H₂₁FN₄O₂

Color and Shape: Solid

Molecular weight: 380.42

Ref: TM-T68736