CAS 763113-22-0: Olaparib

Description: Olaparib is a small molecule inhibitor of the enzyme poly(ADP-ribose) polymerase (PARP), primarily used in cancer therapy, particularly for treating certain types of breast and ovarian cancers associated with BRCA1 and BRCA2 mutations. Its chemical formula is C24H23FN4O3, and it has a molecular weight of approximately 433.46 g/mol. Olaparib is characterized by its ability to induce synthetic lethality in cancer cells by exploiting deficiencies in DNA repair mechanisms. It is typically administered orally and is known for its relatively good bioavailability. The compound exhibits a moderate solubility in water and is lipophilic, which influences its pharmacokinetic properties. Side effects may include nausea, fatigue, and hematological toxicities, reflecting its impact on rapidly dividing cells. Olaparib has been a significant advancement in targeted cancer therapies, representing a shift towards personalized medicine in oncology. Its development has paved the way for further research into PARP inhibitors and their role in cancer treatment.

Formula: C₂₄H₂₃FN₄O₃

InChI: InChI=1S/C24H23FN4O3/c25-20-8-5-15(14-21-17-3-1-2-4-18(17)22(30)27-26-21)13-19(20)24(32)29-11-9-28(10-12-29)23(31)16-6-7-16/h1-5,8,13,16H,6-7,9-12,14H2,(H,27,30)

InChI key: InChIKey=FDLYAMZZIXQODN-UHFFFAOYSA-N

SMILES: O=C1NN=C(C=2C=CC=CC12)CC3=CC=C(F)C(=C3)C(=O)N4CCN(C(=O)C5CC5)CC4

Synonyms:

• 1(2H)-Phthalazinone, 4-[[3-[[4-(cyclopropylcarbonyl)-1-piperazinyl]carbonyl]-4-fluorophenyl]methyl]-
• 1-(Cyclopropylcarbonyl)-4-[5-[(3,4-dihydro-4-oxo-1-phthalazinyl)methyl]-2-fluorobenzoyl]piperazine
• 4-(3-(4-(Cyclopropanecarbonyl)piperazine-1-carbonyl)-4-fluorobenzyl)phthalazin-1(2H)-one
• 4-[3-(4-Cyclopropanecarbonyl-piperazine-1-carbonyl)-4-fluoro-benzyl]-2H-phthalazin-1-one
• 4-[[3-[[4-(Cyclopropylcarbonyl)-1-piperazinyl]carbonyl]-4-fluorophenyl]methyl]-1(2H)-phthalazinone
• Azd 2281
• Azd2281
• Ku 0059436
• Ku 59436
• Lynparza
• Piperazine, 1-(cyclopropylcarbonyl)-4-[5-[(3,4-dihydro-4-oxo-1-phthalazinyl)methyl]-2-fluorobenzoyl]-
• Olaparib

1-(Cyclopropylcarbonyl)-4-[5-[(3,4-dihydro-4-oxo-1-phthalazinyl)methyl]-2-fluorobenzoyl]piperazine

CAS: 763113-22-0

• Formula: C₂₄H₂₃FN₄O₃
• Purity: 98%
• Color and Shape: Solid
• Molecular weight: 434.4628

Olaparib

CAS: 763113-22-0

• Formula: C₂₄H₂₃FN₄O₃
• Color and Shape: White To Off-White Solid
• Molecular weight: 434.47

Olaparib-d4

CAS: 763113-22-0

• Formula: C₂₄H₁₉D₄FN₄O₃
• Color and Shape: White To Off-White Solid
• Molecular weight: 438.50

Olaparib

CAS: 763113-22-0

• Purity: ≥98%
• Molecular weight: 434.46g/mol

Olaparib

CAS: 763113-22-0

• Formula: C₂₄H₂₃FN₄O₃
• Purity: (HPLC) ≥ 98.0%
• Color and Shape: White to off-white powder
• Molecular weight: 434.46

Olaparib

CAS: 763113-22-0

• Formula: C₂₄H₂₃FN₄O₃
• Color and Shape: Neat
• Molecular weight: 434.46

Olaparib

CAS: 763113-22-0

• Formula: C₂₄H₂₃FN₄O₃
• Purity: >95.0%(HPLC)
• Color and Shape: White to Light yellow powder to crystal
• Molecular weight: 434.47

Olaparib

CAS: 763113-22-0

View and buy Olaparib from TargetMol.Olaparib is a small molecule inhibitor of PARP1/PARP2.Cited in 10 …

• Formula: C₂₄H₂₃FN₄O₃
• Purity: 100% - 99.90%
• Color and Shape: Solid
• Molecular weight: 434.46

Olaparib-d4

CAS: 763113-22-0

• Formula: C₂₄D₄H₁₉FN₄O₃
• Color and Shape: Neat
• Molecular weight: 438.49

Olaparib

CAS: 763113-22-0

PARP polymerase inhibitor

• Formula: C₂₄H₂₃FN₄O₃
• Purity: Min. 98 Area-%
• Color and Shape: White Powder
• Molecular weight: 434.46 g/mol

Olaparib - Bio-X ™

CAS: 763113-22-0

Olaparib is a small molecule inhibitor of DNA polymerase and topoisomerase, which are enzymes that …

• Formula: C₂₄H₂₃FN₄O₃
• Purity: Min. 95%
• Color and Shape: Solid
• Molecular weight: 434.46 g/mol

Olaparib

CAS: 763113-22-0

• Formula: C₂₄H₂₃FN₄O₃
• Color and Shape: Neat