CAS 763113-22-0
:Olaparib
Description:
Olaparib is a small molecule inhibitor of the enzyme poly(ADP-ribose) polymerase (PARP), primarily used in cancer therapy, particularly for treating certain types of breast and ovarian cancers associated with BRCA1 and BRCA2 mutations. Its chemical formula is C24H23FN4O3, and it has a molecular weight of approximately 433.46 g/mol. Olaparib is characterized by its ability to induce synthetic lethality in cancer cells by exploiting deficiencies in DNA repair mechanisms. It is typically administered orally and is known for its relatively good bioavailability. The compound exhibits a moderate solubility in water and is lipophilic, which influences its pharmacokinetic properties. Side effects may include nausea, fatigue, and hematological toxicities, reflecting its impact on rapidly dividing cells. Olaparib has been a significant advancement in targeted cancer therapies, representing a shift towards personalized medicine in oncology. Its development has paved the way for further research into PARP inhibitors and their role in cancer treatment.
Formula:C24H23FN4O3
InChI:InChI=1S/C24H23FN4O3/c25-20-8-5-15(14-21-17-3-1-2-4-18(17)22(30)27-26-21)13-19(20)24(32)29-11-9-28(10-12-29)23(31)16-6-7-16/h1-5,8,13,16H,6-7,9-12,14H2,(H,27,30)
InChI key:InChIKey=FDLYAMZZIXQODN-UHFFFAOYSA-N
SMILES:C(C=1C=2C(C(=O)NN1)=CC=CC2)C3=CC(C(=O)N4CCN(C(=O)C5CC5)CC4)=C(F)C=C3
Synonyms:- 1(2H)-Phthalazinone, 4-[[3-[[4-(cyclopropylcarbonyl)-1-piperazinyl]carbonyl]-4-fluorophenyl]methyl]-
- 1-(Cyclopropylcarbonyl)-4-[5-[(3,4-dihydro-4-oxo-1-phthalazinyl)methyl]-2-fluorobenzoyl]piperazine
- 4-(3-(4-(Cyclopropanecarbonyl)piperazine-1-carbonyl)-4-fluorobenzyl)phthalazin-1(2H)-one
- 4-[3-(4-Cyclopropanecarbonyl-piperazine-1-carbonyl)-4-fluoro-benzyl]-2H-phthalazin-1-one
- 4-[[3-[[4-(Cyclopropylcarbonyl)-1-piperazinyl]carbonyl]-4-fluorophenyl]methyl]-1(2H)-phthalazinone
- Azd 2281
- Azd2281
- Ku 0059436
- Ku 59436
- Lynparza
- Piperazine, 1-(cyclopropylcarbonyl)-4-[5-[(3,4-dihydro-4-oxo-1-phthalazinyl)methyl]-2-fluorobenzoyl]-
- See more synonyms
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Found 11 products.
1-(Cyclopropylcarbonyl)-4-[5-[(3,4-dihydro-4-oxo-1-phthalazinyl)methyl]-2-fluorobenzoyl]piperazine
CAS:Formula:C24H23FN4O3Purity:98%Color and Shape:SolidMolecular weight:434.4628Ref: IN-DA0036JX
1g50.00€5g113.00€10g149.00€1kgTo inquire25g213.00€50g318.00€100g518.00€250gTo inquire500gTo inquire100mg29.00€250mg26.00€Olaparib
CAS:Formula:C24H23FN4O3Purity:(HPLC) ≥ 98.0%Color and Shape:White to off-white powderMolecular weight:434.46Olaparib
CAS:<p>View and buy Olaparib from TargetMol.Olaparib is a small molecule inhibitor of PARP1/PARP2.Cited in 10 publications.</p>Formula:C24H23FN4O3Purity:98% - >99.99%Color and Shape:SolidMolecular weight:434.46Olaparib
CAS:<p>PARP polymerase inhibitor</p>Formula:C24H23FN4O3Purity:Min. 98 Area-%Color and Shape:White PowderMolecular weight:434.46 g/molOlaparib - Bio-X ™
CAS:<p>Olaparib is a small molecule inhibitor of DNA polymerase and topoisomerase, which are enzymes that maintain the integrity of DNA. Olaparib inhibits the proliferation of cancer cells by preventing the synthesis of DNA, RNA, and proteins. Olaparib has been shown to be effective against breast cancer tissues in mouse models. It also has minimal toxicity in humans and has been shown to inhibit the growth of diseased cells with significant cytotoxicity.</p>Formula:C24H23FN4O3Purity:Min. 95%Color and Shape:SolidMolecular weight:434.46 g/molOlaparib
CAS:Formula:C24H23FN4O3Purity:>95.0%(HPLC)Color and Shape:White to Light yellow powder to crystalMolecular weight:434.47
![1-(Cyclopropylcarbonyl)-4-[5-[(3,4-dihydro-4-oxo-1-phthalazinyl)methyl]-2-fluorobenzoyl]piperazine](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2FIN%2Fthumb%2FDA0036JX.jpg&w=3840&q=75)
