CAS 7640-51-9

10H-Phenothiazine-10-ethanamine, N,N,α-trimethyl-, 5-oxide

Description:

10H-Phenothiazine-10-ethanamine, N,N,α-trimethyl-, 5-oxide, commonly referred to as a derivative of phenothiazine, is a chemical compound characterized by its phenothiazine backbone, which consists of a sulfur and nitrogen-containing heterocyclic structure. This compound typically exhibits properties such as being a solid at room temperature, with potential applications in pharmaceuticals, particularly as an antipsychotic or antihistamine agent due to its ability to interact with neurotransmitter systems. The presence of the trimethylamine group enhances its solubility and reactivity, making it useful in various chemical reactions. Additionally, the 5-oxide designation indicates the presence of an oxidized nitrogen atom, which can influence the compound's electronic properties and reactivity. Its molecular structure contributes to its biological activity, and it may exhibit fluorescence, making it useful in analytical chemistry. Safety data should be consulted for handling and exposure, as with all chemical substances, to ensure proper precautions are taken.

Formula: C₁₇H₂₀N₂OS

InChI: InChI=1/C17H20N2OS/c1-13(18(2)3)12-19-14-8-4-6-10-16(14)21(20)17-11-7-5-9-15(17)19/h4-11,13H,12H2,1-3H3

InChI key: InChIKey=OWTCLFIFAFHQIX-UHFFFAOYSA-N

SMILES: C(C(N(C)C)C)N1C=2C(S(=O)C=3C1=CC=CC3)=CC=CC2

Synonyms:

• 10-(2-(Dimethylamino)propyl)-10H-phenothiazine 5-oxide
• 10-(2-(Dimethylamino)propyl)-10H-phenothiazine5-oxide
• 10H-Phenothiazine-10-ethanamine, N,N,alpha-trimethyl-, 5-oxide
• 10H-Phenothiazine-10-ethanamine, N,N,α-trimethyl-, 5-oxide
• Diprazin sulfoxide
• N,N,alpha-Trimethyl-10H-phenothiazine-10-ethanamine 5-oxide
• N-[2-(Dimethylamino)propyl]phenothiazine S-oxide
• Phenothiazine, 10-[2-(dimethylamino)propyl]-, 5-oxide
• Promethazine 5-oxide
• Promethazine 5-sulfoxide
• Promethazine sulfoxide
• Romergan sulfoxide
• ProMethazine EP IMpurity D
• N,N,α-TriMethyl-10H-phenothiazine-10-ethanaMine 5-Oxide
• Promethazine Impurity 4(Promethazine EP Impurity D)
• N,N,a-Trimethyl-10H-phenothiazine-10-ethanamine 5-Oxide
• Promethazine Impurity 4(EP Impurity D)
• Promethazine EP Impurity D Dihydrochloride
• PROMETHAZINE EP IMPURITY D (PROMETHAZINE SULFOXIDE)
• (2RS)-N,N-Dimethyl-1-(10H-phenothiazin-10-yl)propan-2-amine S-oxide
• N,N-dimethyl-1-(5-oxophenothiazin-10-yl)propan-2-amine

Promethazine EP Impurity D

CAS: 7640-51-9

Formula: C₁₇H₂₀N₂OS

Molecular weight: 300.42

Ref: ST-EA-CP-P86004

Promethazine Sulphoxide 1.0 mg/ml in Methanol

CAS: 7640-51-9

Color and Shape: Single Solution

Ref: 61-AMP0412.04-01

Promethazine sulfoxide

CAS: 7640-51-9

Promethazine sulfoxide

Formula: C₁₇H₂₀N₂OS

Color and Shape: White Solid

Molecular weight: 300.4185

Ref: 47-505

PROMETHAZINE IMPURITY D CRS

CAS: 7640-51-9

PROMETHAZINE IMPURITY D CRS

Ref: 41-Y0000769

Promethazine Sulfoxide

CAS: 7640-51-9

Compounds (excluding drugs) containing a phenothiazine ring-system (whether or not hydrogenated), not further fused

Formula: C₁₇H₂₀N₂OS

Color and Shape: Grey Powder

Molecular weight: 300.12963

Ref: 45-1A10030

10-(2-(Dimethylamino)propyl)-10H-phenothiazine 5-oxide

CAS: 7640-51-9

Formula: C₁₇H₂₀N₂OS

Purity: 95%

Color and Shape: Solid

Molecular weight: 300.4185

Ref: IN-DA008QHQ

Promethazine EP Impurity D (Promethazine Sulfoxide)

CAS: 7640-51-9

Formula: C₁₇H₂₀N₂OS

Color and Shape: White To Off-White Solid

Molecular weight: 300.42

Ref: 4Z-P-181

10-(2-(Dimethylamino)propyl)-10H-phenothiazine 5-oxide

CAS: 7640-51-9

10-(2-(Dimethylamino)propyl)-10H-phenothiazine 5-oxide

Purity: 95%

Molecular weight: 300.43g/mol

Ref: 54-OR1046044

Promethazine EP Impurity D

Controlled Product

CAS: 7640-51-9

Formula: C₁₇H₂₀N₂OS

Color and Shape: Neat

Molecular weight: 300.42

Ref: 86-MM0412.04

Promethazine Sulfoxide

Controlled Product

CAS: 7640-51-9

Impurity Promethazine EP Impurity D
Applications Promethazine Sulfoxide (Promethazine EP Impurity D) is a metabolite of Promethazine (P757000).
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Gottschalk, L., et al.: J. Pharm. Sci., 67, 155 (1978), de Jongh, G., et al.: Drug Metab. Dispos., 9, 48 (1981), Hale, P., et al.: Toxicol. Appl. Pharmacol., 86, 44 (1986), Delbressine, L., et al.: Xenobiotica, 22, 227 (1992),

Formula: C₁₇H₂₀N₂OS

Color and Shape: Light Red To Purple

Molecular weight: 300.42

Ref: TR-P757010

Promethazine sulfoxide

CAS: 7640-51-9

Promethazine sulfoxide is a phenothiazine derivative that is used in the treatment of allergies, colds, and motion sickness. It has been shown to inhibit peroxidases and reactions involving the production of hydrogen peroxide. Promethazine sulfoxide is metabolized by two pathways: one involving oxidation by cytochrome P450 enzymes and another involving hydrolysis by esterases or glucuronidases. The main metabolites are promethazine, promethazine sulfone, and N-methylpromethazine. When applied to urine samples, promethazine sulfoxide can be detected in concentrations of 1-10 ng/mL with an analytical method based on chromatography.

Formula: C₁₇H₂₀N₂OS

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 300.42 g/mol

Ref: 3D-FP27184

Promethazine Sulphoxide

CAS: 7640-51-9

Color and Shape: Neat

Ref: 61-FOR0412.04