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CAS 76420-72-9

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Enalaprilat

Description:
Enalaprilat is the active metabolite of the angiotensin-converting enzyme (ACE) inhibitor enalapril, primarily used in the treatment of hypertension and heart failure. It is a white to off-white crystalline powder that is soluble in water and exhibits a pH range typically between 4.5 and 7.5 in solution. The molecular formula of enalaprilat is C20H28N2O5S, and it has a molecular weight of approximately 396.52 g/mol. Enalaprilat functions by inhibiting the ACE enzyme, which plays a crucial role in the renin-angiotensin-aldosterone system, leading to vasodilation and reduced blood pressure. Its pharmacokinetics indicate that it has a relatively long half-life, allowing for effective management of blood pressure with once or twice daily dosing. Common side effects may include hypotension, hyperkalemia, and renal impairment, particularly in patients with pre-existing conditions. As with other ACE inhibitors, caution is advised in patients with a history of angioedema or those who are pregnant.
Formula:C18H24N2O5
InChI:InChI=1S/C18H24N2O5/c1-12(16(21)20-11-5-8-15(20)18(24)25)19-14(17(22)23)10-9-13-6-3-2-4-7-13/h2-4,6-7,12,14-15,19H,5,8-11H2,1H3,(H,22,23)(H,24,25)/t12-,14-,15-/m0/s1
InChI key:InChIKey=LZFZMUMEGBBDTC-QEJZJMRPSA-N
SMILES:C([C@@H](N[C@@H](CCC1=CC=CC=C1)C(O)=O)C)(=O)N2[C@H](C(O)=O)CCC2
Synonyms:
  • (2S)-1-[(2S)-2-[[(1S)-1-Carboxy-3-phenyl-propyl]amino]propanoyl]pyrrolidine-2-carboxylic acid
  • <span class="text-smallcaps">L</smallcap>-Proline, 1-[N-(1-carboxy-3-phenylpropyl)-<smallcap>L</span>-alanyl]-, (S)-
  • <span class="text-smallcaps">L</smallcap>-Proline, N-[(1S)-1-carboxy-3-phenylpropyl]-<smallcap>L</span>-alanyl-
  • Enalapril acid
  • Enalapril diacid
  • Enalaprilat Hydrate
  • Enalaprilat Usp(Crm Standard)
  • Enalaprilate
  • Enalaprilic Acid
  • MK 421 diacid
  • See more synonyms
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