CAS 76455-48-6

4-bromocalcimycin A23187

Description:

4-Bromocalcimycin A23187, with the CAS number 76455-48-6, is a calcium ionophore that belongs to the class of polyether antibiotics. It is derived from the fermentation of certain Streptomyces species and is known for its ability to facilitate the transport of calcium ions across biological membranes. This compound exhibits a unique structure characterized by a polyether backbone, which allows it to form complexes with cations, particularly calcium. Its bromine substitution at the 4-position enhances its lipophilicity and biological activity. 4-Bromocalcimycin A23187 is utilized in various biochemical and pharmacological studies, particularly in research involving calcium signaling and ion transport mechanisms. Additionally, it has applications in cell biology, where it is used to manipulate intracellular calcium levels, thereby influencing cellular processes such as muscle contraction, neurotransmitter release, and cell proliferation. However, due to its potent biological effects, it must be handled with care in laboratory settings.

Formula: C₂₉H₃₆BrN₃O₆

InChI: InChI=1/C29H36BrN3O6/c1-14-8-9-29(16(3)11-15(2)27(39-29)17(4)26(34)19-7-6-10-32-19)38-20(14)13-22-33-25-21(37-22)12-18(30)24(31-5)23(25)28(35)36/h6-7,10,12,14-17,20,27,31-32H,8-9,11,13H2,1-5H3,(H,35,36)/t14-,15-,16-,17-,20-,27+,29?/m1/s1

Synonyms:

• 4-Bromo-A-23187
• 4-Br-A23187
• 4-Bra23187
• 4-Benzoxazolecarboxylic acid, 6-bromo-5-(methylamino)-2-(((2S,3S,6S,8S,9R,11R)-3,9,11-trimethyl-8-((1S)-1-methyl-2-oxo-2-(1H-pyrrol-2-yl)ethyl)-1,7-dioxaspiro(5.5)undec-2-yl)methyl)-
• 4-Benzoxazolecarboxylic acid, 6-bromo-5-(methylamino)-2-((3,9,11-trimethyl-8-(1-methyl-2-oxo-2-(1H-pyrrol-2-yl)ethyl)-1,7-dioxaspiro(5.5)undec-2-yl)methyl)-, (6S-(6alpha(2S*,3S*),8beta(R*),9beta,11alpha))-
• 6-bromo-5-(methylamino)-2-({(2R,3R,8S,9R,11R)-3,9,11-trimethyl-8-[(2S)-1-oxo-1-(1H-pyrrol-2-yl)propan-2-yl]-1,7-dioxaspiro[5.5]undec-2-yl}methyl)-1,3-benzoxazole-4-carboxylic acid

4-Bromo-calcium Ionophore A23187

CAS: 76455-48-6

4-Bromo-calcium Ionophore A23187

Molecular weight: 602.52g/mol

Ref: 54-BIB1001

4-Bromo-calcium Ionophore A23187

CAS: 76455-48-6

Formula: C₂₉H₃₆BrN₃O₆

Purity: ≥ 98.0%

Color and Shape: Light yellow to yellow crystals

Molecular weight: 602.52

Ref: 7W-GA5945

4-Bromo-A23187

Controlled Product

CAS: 76455-48-6

Applications 4-Bromo-A23187 is an ionophore that transports Zn2+ and Mn2+ with high selectivity over Ca2+.
References Park, J. Genevieve, et al.: Methods in Mol. Bio., 1071, 29-47 (2014);Erdahl, Warren L., et al.: Biochem., 35(43), 13817-13825 (1996)

Formula: C₂₉H₃₆BrN₃O₆

Color and Shape: Neat

Molecular weight: 602.517

Ref: TR-B677765

4-Bromo-A23187

CAS: 76455-48-6

Non-fluorescent Ca2+ ionophore; for calibrating fluorescent Ca2+ probes

Purity: Min. 95%

Ref: 3D-BB162705

4-Bromo A23187

CAS: 76455-48-6

4-Bromo A23187 is a halogenated analog of the calcium ionophore A-23187. 4-Bromo A23187 is a calcium modulator and induces apoptosis in different cells.

Formula: C₂₉H₃₆BrN₃O₆

Purity: 98%

Color and Shape: Solid

Molecular weight: 602.52

Ref: TM-T10137